Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ion Suehiro"'
Autor:
A Kennedy, Aaron C. Hinken, William F. Browne, Kwan Leung, Matthew Tomlinson, Bradley P Morgan, James J. Hartman, Pu-Ping Lu, Gustave Bergnes, Fady I. Malik, David J. Morgans, Alexander Muci, David Marquez, Marc Garard, Ion Suehiro, Scott Collibee, Kenneth Lee, Donghong Xu, Alan J. Russell, Julia Schaletzky, Raja Kawas, Darren Hwee
Publikováno v:
ACS Medicinal Chemistry Letters
The identification and optimization of the first activators of fast skeletal muscle are reported. Compound 1 was identified from high-throughput screening (HTS) and subsequently found to improve muscle function via interaction with the troponin compl
Autor:
Katjuša Brejc, Jeffrey T. Finer, Maria Pokrovskii, David R. Cox, Daniel W. Pierce, Marc Garard, Ramesh Baliga, Congrong Niu, Todd Tochimoto, Kathleen A. Elias, Guillermo Godinez, Stephen F. Vatner, You Tang Shen, Roman Sakowicz, Bradley P. Morgan, Sandra H. Sueoka, Pu Ping Lu, Fady I. Malik, Tatsuo Katori, Alexander Muci, David Lenzi, David J. Morgans, Corey Valdez, Sheila Sylvester, Kenneth Lee, Xiangping Qian, Ion Suehiro, Erica Kraynack, Raja Kawas, David A. Kass, James J. Hartman, Hector P. Rodriguez, Robert L. Anderson, Wenyue Wang
Publikováno v:
Science. 331:1439-1443
Decreased cardiac contractility is a central feature of systolic heart failure. Existing drugs increase cardiac contractility indirectly through signaling cascades but are limited by their mechanism-related adverse effects. To avoid these limitations
Autor:
Todd Tochimoto, Zhengping Wang, Erica Kraynack, Xiangping Qian, Sheila Sylvester, Ion Suehiro, Alexander Muci, Hong Jiang, S. Corey Valdez, Adam Lewis Tomasi, Smith Whitney W, Kenneth Lee, Robert F. Anderson, Marc Garard, James J. Hartman, Donghong Xu, Hector M. Rodriguez, Guillermo Godinez, Sandra H. Sueoka, Pu-Ping Lu, Scott Collibee, Fady I. Malik, Wenyue Wang, Raja Kawas, Bradley P. Morgan, Nebojsa Djordjevic, Kathleen A. Elias, David J. Morgans
Publikováno v:
ACS Medicinal Chemistry Letters. 1:472-477
We report the design, synthesis, and optimization of the first, selective activators of cardiac myosin. Starting with a poorly soluble, nitro-aromatic hit compound (1), potent, selective, and soluble myosin activators were designed culminating in the
Publikováno v:
The Annals of pharmacotherapy. 48(10)
Objective: To report successful use of low-volume intrathecal (IT) daptomycin and loading strategy for the treatment of ventriculostomy-associated meningitis. Case Summary: A 23-year-old man with a history of multiple ventriculoperitoneal shunt revis