Výsledky vyhledávání - "Ion Channels/Membrane Transport"

Akademický článek

Heart Rate–Induced Myocardial Ca2+ Retention and Left Ventricular Volume Loss in Patients With Heart Failure With Preserved Ejection Fraction

Autor: Daniel N. Silverman, Mehdi Rambod, Daniel L. Lustgarten, Robert Lobel, Martin M. LeWinter, Markus Meyer

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 17 (2020)

Background Increases in heart rate are thought to result in incomplete left ventricular (LV) relaxation and elevated filling pressures in patients with heart failure with preserved ejection fraction (HFpEF). Experimental studies in isolated human myo

Externí odkaz: https://doaj.org/article/bffe058803d94304b13f0c671a47b9b0

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Unravelling Atrioventricular Block Risk in Inflammatory Diseases: Systemic Inflammation Acutely Delays Atrioventricular Conduction via a Cytokine-Mediated Inhibition of Connexin43 Expression

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 21 (2021)

Background Recent data suggest that systemic inflammation can negatively affect atrioventricular conduction, regardless of acute cardiac injury. Indeed, gap‐junctions containing connexin43 coupling cardiomyocytes and inflammation‐related cells (m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a14dc0ad90d1930ab3b7ed13e58cc2a
https://pubmed.ncbi.nlm.nih.gov/34713715

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Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia

Autor: Stephan Aynaszyan, Kenneth D. Philipson, Michela Ottolia, Christina Grabar, Devina Gonzalez, Rui Zhang, Adina Hazan, Joshua I. Goldhaber, Sabine Lotteau

Publikováno v: Journal of the American Heart Association, vol 10, iss 17
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021)

Background Sodium‐calcium (Ca 2+ ) exchanger isoform 1 (NCX1) is the dominant Ca 2+ efflux mechanism in cardiomyocytes and is critical to maintaining Ca 2+ homeostasis during excitation‐contraction coupling. NCX1 activity has been implicated in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41667a9839be13d0c4d9ab895f3596eb
https://escholarship.org/uc/item/0gp7c26c

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Angiotensin II Disrupts Neurovascular Coupling by Potentiating Calcium Increases in Astrocytic Endfeet

Autor: Hélène Girouard, Michaël Boily, Diane Vallerand, Lin Li

Background Angiotensin II (Ang II), a critical mediator of hypertension, impairs neurovascular coupling. Since astrocytes are key regulators of neurovascular coupling, we sought to investigate whether Ang II impairs neurovascular coupling through mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadef608955c7d69b56f71e8a3cfde23
https://pubmed.ncbi.nlm.nih.gov/34459216

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Recurrent Pregnancy Loss and Concealed Long-QT Syndrome

Autor: Maris Laan, Tao Yang, Laura Kasak, Kristiina Rull, Dan M. Roden

Background Recurrent pregnancy loss affects 1% to 2% of couples attempting childbirth. A large fraction of all cases remains idiopathic, which warrants research into monogenic causes of this distressing disorder. Methods and Results We investigated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368367396d8a66ebb27526f04f59eddc
https://pubmed.ncbi.nlm.nih.gov/34398675

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Novel RyR2 Mutation (G3118R) Is Associated With Autosomal Recessive Ventricular Fibrillation and Sudden Death: Clinical, Functional, and Computational Analysis

Autor: Jinhong Wei, David Luria, Ruiwu Wang, S. R. Wayne Chen, Oded Shor, Yair Elitzur, Nataly Kucherenko, Ayelet Shauer, Yulia Einav

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background The cardiac ryanodine receptor type 2 (RyR2) is a large homotetramer, located in the sarcoplasmic reticulum (SR), which releases Ca 2+ from the SR during systole. The molecular mechanism underlying Ca 2+ sensing and gating of the RyR2 chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4faf5a0cc7af5400711b69a17a3ef9
https://pubmed.ncbi.nlm.nih.gov/33686871

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Identification of Key Small Non-Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node

Autor: Luke Stuart, Delvac Oceandy, Yu Zhang, Connor Geragthy, Halina Dobrzynski, Vadim V. Fedorov, Joseph Yanni, Alicia D'Souza, Andrew Atkinson, Alexandra Ivanova, Filip Virgil Perde, K. B. Pustovit, Amy Feather, Maria Petkova, Ning Li, Peter C. M. Molenaar, Abimbola J. Aminu

Publikováno v: Petkova, M, Atkinson, A J, Yanni, J, Stuart, L, Aminu, A J, Perde, F, Molenaar, P, Fedorov, V V & Dobrzynski, H 2020, ' Identification of Key Small Non-Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node ', Journal of the American Heart Association, vol. 9, no. 20, pp. e016590 . https://doi.org/10.1161/JAHA.120.016590
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background The sinus node (SN) is the primary pacemaker of the heart. SN myocytes possess distinctive action potential morphology with spontaneous diastolic depolarization because of a unique expression of ion channels and Ca 2+ ‐handling proteins.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fedbb97322ca1ae9ce471df7c5e9b9
https://www.research.manchester.ac.uk/portal/en/publications/identification-of-key-small-noncoding-micrornas-controlling-pacemaker-mechanisms-in-the-human-sinus-node(082a62a1-035b-4454-97c8-0659839874a9).html

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Neurohormonal Regulation of I

Autor: Tyler, Shugg, Andy, Hudmon, Brian R, Overholser

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Heart failure (HF) results in sustained alterations in neurohormonal signaling, including enhanced signaling through the sympathetic nervous system and renin‐angiotensin‐aldosterone system pathways. While enhanced sympathetic nervous system and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bad9b174f1376ba4ce928d861ab64b20
https://pubmed.ncbi.nlm.nih.gov/32865116

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Low voltage-activated channels in rat pulmonary vein cardiomyocytes: coexistence of a non-selective cationic channel and of T-type Ca channels

Autor: Claire O. Malécot

Publikováno v: Pflügers Archiv European Journal of Physiology
Pflügers Archiv European Journal of Physiology, Springer Verlag, 2020, 472, pp.1019-1029. ⟨10.1007/s00424-020-02413-1⟩

International audience; In rat pulmonary vein (PV) cardiomyocytes (CM), norepinephrine (NE) induces an automatic activity consisting of bursts of slow action potentials which depend on Ca2+ (upstroke) and Na+ (inter-burst) channels. Our objective was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc057e22218dfbfbe5047e9ef879f988
https://hal.archives-ouvertes.fr/hal-02881260

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