Výsledky vyhledávání - "Ion C Cirstea"

Akademický článek

Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.

Autor: Si-Cai Zhang, Lothar Gremer, Henrike Heise, Petra Janning, Aliaksei Shymanets, Ion C Cirstea, Eberhard Krause, Bernd Nürnberg, Mohammad Reza Ahmadian

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102425 (2014)

Small Rho GTPases are well known to regulate a variety of cellular processes by acting as molecular switches. The regulatory function of Rho GTPases is critically dependent on their posttranslational modification at the carboxyl terminus by isoprenyl

Externí odkaz: https://doaj.org/article/fcd4875f56614d2eabdbcf0693029d43

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A novel in vitro assay to study chondrocyte-to-osteoblast transdifferentiation

Autor: Melanie Haffner-Luntzer, Anita Ignatius, Sayantan Nandi, Attila Aszodi, Miriam Tschaffon, Ion C. Cirstea, Astrid Schoppa, Stefan O. Reber

Publikováno v: Endocrine

Purpose Endochondral ossification, which involves transdifferentiation of chondrocytes into osteoblasts, is an important process involved in the development and postnatal growth of most vertebrate bones as well as in bone fracture healing. To study t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed63c5293503e009a031f1ca3c8a71a
https://doi.org/10.1007/s12020-021-02853-4

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Glucocorticoid receptor and RAS: an unexpected couple in cancer

Autor: Ion C. Cirstea, Herwig P. Moll, Jan Tuckermann

Publikováno v: Trends in Cell Biology.

Constitutively activated rat sarcoma (RAS) GTPases are one of the major drivers of tumor growth and are difficult drug targets. The glucocorticoid receptor (GR), a nuclear receptor primarily acting in the nucleus, is a potent modulator of inflammatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9765ab32b77c0f8e82c5389b1b6be6b4
https://doi.org/10.1016/j.tcb.2022.11.002

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Studying Metabolic Abnormalities in the Costello Syndrome HRAS G12V Mouse Model: Isolation of Mouse Embryonic Fibroblasts and Their In Vitro Adipocyte Differentiation

Autor: Ion C. Cirstea, Miray Fidan, Saravanakkumar Chennappan

Publikováno v: Methods in Molecular Biology ISBN: 9781071611890

Costello syndrome (CS), characterized by a developmental delay and a failure to thrive, is also associated with an impaired lipid and energy metabolism. White adipose tissue is a central sensor of whole-body energy homeostasis, and HRAS hyperactivati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c42f9f802945226324c98da32b68627
https://doi.org/10.1007/978-1-0716-1190-6_24

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Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model

Autor: Tanja Schulze, Ion C. Cirstea, Saravanakkumar Chennappan

Publikováno v: Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model. :3-14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6361492a373fbd6e7d9f267bc024ad0b
https://doi.org/10.26600/mollife.1.1.1.2017

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AberrantHRAStranscript processing underlies a distinctive phenotype within the RASopathy clinical spectrum

Autor: Mohammad Reza Ahmadian, Stefano Paolacci, Dorit Lev, Ion C. Cirstea, Francesca Pantaleoni, Serena Cecchetti, Alessandra Carè, Antonio Novelli, Marco Tartaglia, Elisabetta Flex, Marialetizia Motta, Lisabianca Bottero, Ilan Linger, Francesca Romana Lepri, Emilia Stellacci

Publikováno v: Human Mutation. 38:798-804

RASopathies are a group of rare, clinically related conditions affecting development and growth, and are caused by germline mutations in genes encoding signal transducers and modulators with a role in the RAS signaling network. These disorders share

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3291198ebe5711a1f461665aa0e3e15
https://doi.org/10.1002/humu.23224

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Dominant Noonan syndrome-causing LZTR1 mutations specifically affect the Kelch domain substrate-recognition surface and enhance RAS-MAPK signaling

Autor: Ion C. Cirstea, Konstantin Schneider-Heieck, Francesca Pantaleoni, Emanuele Bellacchio, Simona Coppola, Miray Fidan, Guntram Borck, Martin Zenker, Leonardo Salviati, Marco Tartaglia, Marialetizia Motta

Noonan syndrome (NS), the most common RASopathy, is caused by mutations affecting signaling through RAS and the MAPK cascade. Recently, genome scanning has discovered novel genes implicated in NS, whose function in RAS-MAPK signaling remains obscure,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2034afdd233750056fe3289e8200b96f
http://hdl.handle.net/11577/3384318

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Senescence in RASopathies, a possible novel contributor to a complex pathophenoype

Autor: Miray Fidan, Melanie Engler, Sayantan Nandi, Ion C. Cirstea

Publikováno v: Mechanisms of Ageing and Development. 194:111411

Senescence is a biological process that induces a permanent cell cycle arrest and a specific gene expression program in response to various stressors. Following studies over the last few decades, the concept of senescence has evolved from an antiprol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bb74d11655760024f5411f9bf6cf3d
https://doi.org/10.1016/j.mad.2020.111411

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