Proinflammatory Responses of Heme in Alveolar Macrophages: Repercussion in Lung Hemorrhagic Episodes

Autor: Rafael L. Simões, Maria Augusta Arruda, Cláudio Canetti, Carlos H. Serezani, Iolanda M. Fierro, Christina Barja-Fidalgo

Publikováno v: Mediators of Inflammation, Vol 2013 (2013)

Clinical and experimental observations have supported the notion that free heme released during hemorrhagic and hemolytic episodes may have a major role in lung inflammation. With alveolar macrophages (AM) being the main line of defense in lung envir

Externí odkaz: https://doaj.org/article/1ec1bcec84304d59862b6f436db399eb

Lipoxin A4selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression

Autor: Natália Mesquita de-Brito, V Morandi, Ivan M. Roitt, Iolanda M. Fierro, H Cunha-Costa, Rafael L. Simões, Christina Barja-Fidalgo

Publikováno v: International Journal of Cancer. 140:346-357

In tumor microenvironments, the macrophage population is heterogeneous, but some macrophages can acquire tumor-promoting characteristics. These tumor-associated macrophages (TAM) exhibit an M2-like profile, with deficient production of NO and ROS, ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::537cc59bb2ed544fc92da1e252d6efeb
https://doi.org/10.1002/ijc.30424

New strategies for patenting biological medicines used in rheumatoid arthritis treatment

Autor: Rodrigo Ayres de Oliveira, Iolanda M. Fierro

Publikováno v: Expert opinion on therapeutic patents. 28(8)

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an inflammatory process, with a global prevalence ranging from 0.3% to 1%. The overall cost of RA drugs is estimated in $20 billion worldwide and projected to grow to $36 bill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf1b38dd5f2f341f7cd8c808ed017ba
https://pubmed.ncbi.nlm.nih.gov/30047807

Nanoparticles applied to antineoplastic agents: a patent landscape

Autor: Iolanda M. Fierro, Maria Simone de Menezes Alencar, Bernardo Furtado Nunes, Cristina d'Urso de Souza Mendes, Flavia Maria Lins Mendes, Adelaide Maria de Souza Antunes

Publikováno v: Pharmaceutical Patent Analyst. 3:613-623

Recently, research in the field of cancer nanotechnology has made notable progress, and, with the fast development of nanomaterials, new treatment strategies using nanoparticles are being explored that have the potential to overcome existing problems

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85b62393ed6e0156638583f1a317ea1
https://doi.org/10.4155/ppa.14.47

Trends in Nanopharmaceutical Patents

Autor: Iolanda M. Fierro, Adelaide Maria de Souza Antunes, Rafaela Di Sabato Guerrante, Maria Simone de Menezes Alencar, Flávia R L Mendes

Publikováno v: International Journal of Molecular Sciences, Vol 14, Iss 4, Pp 7016-7031 (2013)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 14; Issue 4; Pages: 7016-7031

Investment in nanotechnology is now a given constant by governments, research centers and companies in both more developed countries and emerging markets. Due to their characteristics, such as high stability, ability to enable antigen identification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a16936efb1ecf33b6b0e6c7f18c326e
http://www.mdpi.com/1422-0067/14/4/7016