How are thermodynamically stable G-quadruplex–duplex hybrids?

Autor: Iolanda Fotticchia, Bruno Pagano, Ettore Novellino, Concetta Giancola, Jussara Amato, Luigi Petraccone

Publikováno v: Journal of Thermal Analysis and Calorimetry. 121:1121-1127

In the last decade, DNA duplex and G-quadruplex motifs have been investigated for their potential applications in nanotechnology. Recently, G-quadruplex-duplex hybrids, generated from the juxtaposition of these two structural elements, have been cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1392518427de31a23851f2233f314943
https://doi.org/10.1007/s10973-015-4588-y

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

Autor: Jessica Marinello, Alessio De Magis, Giorgio Amendola, Giovanni Capranico, Bruno Pagano, Jussara Amato, Ettore Novellino, Alessia Pagano, Sandro Cosconati, Nunzia Iaccarino, Antonio Randazzo, Iolanda Fotticchia

Background Guanine-rich DNA motifs can form non-canonical structures known as G-quadruplexes, whose role in tumorigenic processes makes them attractive drug-target candidates for cancer therapy. Recent studies revealed that the folding and unfolding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e0d2c6ffdc29ad7afb6370c52cd339
http://hdl.handle.net/11588/649927

Cyclodextrin-assisted assembly of PEGylated polyester nanoparticles decorated with folate

Autor: Francesca Ungaro, Pasquale Tirino, Bruno Pagano, Fabiana Quaglia, Claudia Conte, Francesca Moret, Elena Reddi, Ruxandra Gref, Concetta Giancola, Iolanda Fotticchia

In the last decades, nano-oncologicals bearing a polyethylene glycol (PEG) coating are being emerging as biomimetic devices able to drive their drug cargo to solid tumors through passive mechanisms. To improve selectivity toward cancer cells, nanocar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4360757561f652ae79e7cee83e1f131
http://hdl.handle.net/11588/641225

Energetics of ligand-receptor binding affinity on endothelial cells: An in vitro model

Autor: Raffaele Vecchione, Paolo A. Netti, Andrea Patrizia Falanga, Daniela Guarnieri, Teresa Fotticchia, Concetta Giancola, Iolanda Fotticchia

Publikováno v: Colloids and surfaces. B, Biointerfaces. 144

Targeted therapies represent a challenge in modern medicine. In this contest, we propose a rapid and reliable methodology based on Isothermal Titration Calorimetry (ITC) coupled with confluent cell layers cultured around biocompatible templating micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c362a591dd0e186a31f8a85af13fc896
https://pubmed.ncbi.nlm.nih.gov/27100851

Shading the TRF2 Recruiting Function: A New Horizon in Drug Development

Autor: Annamaria Biroccio, Iolanda Fotticchia, Bruno Pagano, Clemente Capasso, Eric Gilson, Luciana Marinelli, Erica Salvati, Ettore Novellino, Salvatore Di Maro, Viviana De Luca, Pasquale Zizza, Sandro Cosconati

Publikováno v: Journal of the American Chemical Society
136 (2014): 16708–16711. doi:10.1021/ja5080773
info:cnr-pdr/source/autori:Di Maro, Salvatore; Zizza, Pasquale; Salvati, Erica; De Luca, Viviana; Capasso, Clemente; Fotticchia, Iolanda; Pagano, Bruno; Marinelli, Luciana; Gilson, Eric; Novellino, Ettore; Cosconati, Sandro; Biroccio, Annamaria/titolo:Shading the TRF2 Recruiting Function: A New Horizon in Drug Development/doi:10.1021%2Fja5080773/rivista:Journal of the American Chemical Society (Print)/anno:2014/pagina_da:16708/pagina_a:16711/intervallo_pagine:16708–16711/volume:136

The shelterin protein TRF2 has come to the limelight for its role in telomere maintenance and tumorigenesis. Herein, the application of rational design and synthesis allowed identifying the first TRF2(TRFH) binder able to elicit a marked DNA damage r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f58c749880a6835e2cf4ca88156efb
http://hdl.handle.net/11591/194429