Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Iok-Hou Pang"'
Autor:
Xiaobin Liu, Keith Ward, Christy Xavier, Jamieson Jann, Abbot F. Clark, Iok-Hou Pang, Hongli Wu
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 98-109 (2016)
Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is an important factor in the pathogenesis of age-related macular degeneration (AMD). Previous studies have shown that RTA 408, a synthetic triterpenoid compound, potently activate
Externí odkaz:
https://doaj.org/article/1c0f93f6320e42dabc7b56db70e2761a
Publikováno v:
Neurobiology of Disease, Vol 59, Iss , Pp 26-37 (2013)
The p38 mitogen-activated protein kinase (MAPK) isoforms are phosphorylated by a variety of stress stimuli in neurodegenerative disease and act as upstream activators of myriad pathogenic processes. Thus, p38 MAPK inhibitors are of growing interest a
Externí odkaz:
https://doaj.org/article/c67db30c1edb4d468f5242b7a776932d
Autor:
Kimberly A. Fernandes, Jeffrey M. Harder, Laura B. Fornarola, Robert S. Freeman, Abbot F. Clark, Iok-Hou Pang, Simon W.M. John, Richard T. Libby
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 2, Pp 393-401 (2012)
Glaucoma is a neurodegenerative disease characterized by the apoptotic death of retinal ganglion cells (RGCs). The primary insult to RGCs in glaucoma is thought to occur to their axons as they exit the eye in the optic nerve head. However, pathologic
Externí odkaz:
https://doaj.org/article/1fcb64a2048241429e4938ae34550e85
Autor:
Chang Dai, Prabuddha Waduge, Liyang Ji, Chengchi Huang, Ye He, Hong Tian, Elizabeth Zuniga-Sanchez, Amit Bhatt, Iok-Hou Pang, Guanfang Su, Keith A. Webster, Wei Li
Publikováno v:
Cell Mol Life Sci
Conventional angiogenic factors, such as vascular endothelial growth factor (VEGF), regulate both pathological and physiological angiogenesis indiscriminately, and their inhibitors may elicit adverse side effects. Secretogranin III (Scg3) was recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b31354372255d4c03d8b66e8bf78f11
https://europepmc.org/articles/PMC9007175/
https://europepmc.org/articles/PMC9007175/
Publikováno v:
Experimental neurology. 334
Retinal ganglion cell (RGC) death causes irreversible blindness in adult mammals. Death of RGC occurs in diseases including glaucoma or injuries to the optic nerve (ON). To investigate mechanisms involved in RGC degeneration, we evaluated the phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2b09135a26dfae1af79b345c9369e3
https://pubmed.ncbi.nlm.nih.gov/32971066
https://pubmed.ncbi.nlm.nih.gov/32971066
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fb52e712bd2c3e05d51819675eb869
https://doi.org/10.1155/2017/1703810
https://doi.org/10.1155/2017/1703810
Publikováno v:
Experimental eye research. 188
Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness, and individuals with ocular hypertension are at risk to develop POAG. Currently, the only modifiable risk factor for glaucoma progression is lowering of intraocular pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcb81d98d6db5fa3d5b29f25581558d
https://pubmed.ncbi.nlm.nih.gov/31421135
https://pubmed.ncbi.nlm.nih.gov/31421135
Autor:
Iok-Hou Pang, Jacky M. K. Kwong
Publikováno v:
Medical Treatment of Glaucoma ISBN: 9789811327322
Current treatments for primary open-angle glaucoma, be they medication or surgery, only manage the symptom of ocular hypertension. They do not address the underlying mechanisms of pathogenesis or pathophysiology of the disease. Therefore, they do not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85f5c860e0ee32da87caf26a507182b0
https://doi.org/10.1007/978-981-13-2733-9_7
https://doi.org/10.1007/978-981-13-2733-9_7
Autor:
Ning Fan, Junkai Tan, Jingxue Zhang, Xiaolin Luo, Guo Liu, Shen Wu, Iok-Hou Pang, Xuyang Liu, Chunlin Lan, Ningli Wang
Publikováno v:
Life Sciences. 272:119269
Aims Our previous study showed that intravitreal delivery of self-complementary AAV2 (scAAV2)-mediated exoenzyme C3 transferase (C3) can attenuate retinal ischemia/reperfusion (I/R) injury. The current study investigated the neuroprotective effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd6c1d46474eaa5f5fb6e635a6c1032
https://doi.org/10.1016/j.lfs.2021.119269
https://doi.org/10.1016/j.lfs.2021.119269
Autor:
Jamieson Jann, Iok-Hou Pang, Hongli Wu, Christy Xavier, Keith W. Ward, Abbot F. Clark, Xiaobin Liu
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 98-109 (2016)
Redox Biology
Redox Biology
Graphical abstract
Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is an important factor in the pathogenesis of age-related macular degeneration (AMD). Previous studies have shown that RTA 408, a synthetic triterpenoid com
Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is an important factor in the pathogenesis of age-related macular degeneration (AMD). Previous studies have shown that RTA 408, a synthetic triterpenoid com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e222fbd5018d0f4ab1fced9e19b7f7d
https://doi.org/10.1016/j.redox.2015.12.005
https://doi.org/10.1016/j.redox.2015.12.005