Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Iogann Tolbatov"'
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 530 (2024)
Metallodrugs are an important group of medicinal agents used for the treatment of various diseases ranging from cancers to viral, bacterial, and parasitic diseases. Their distinctive features include the availability of a metal centre, redox activity
Externí odkaz:
https://doaj.org/article/9dd32c068f7941c4a5025212add5646b
Autor:
Iogann Tolbatov, Alessandro Marrone
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 985 (2023)
Recently, the well-characterized metallodrug auranofin has been demonstrated to restore the penicillin and cephalosporin sensitivity in resistant bacterial strains via the inhibition of the NDM-1 beta-lactamase, which is operated via the Zn/Au substi
Externí odkaz:
https://doaj.org/article/296c2110efda45b2a2634e45d4bba04e
Autor:
Lorenzo Chiaverini, Alessandro Pratesi, Damiano Cirri, Arianna Nardinocchi, Iogann Tolbatov, Alessandro Marrone, Mariagrazia Di Luca, Tiziano Marzo, Diego La Mendola
Publikováno v:
Molecules, Vol 27, Iss 8, p 2578 (2022)
Auranofin (AF, hereafter) is an orally administered chrysotherapeutic agent approved for the treatment of rheumatoid arthritis that is being repurposed for various indications including bacterial infections. Its likely mode of action involves the imp
Externí odkaz:
https://doaj.org/article/6550c009dca54cbda020e06527a74ef8
Autor:
Iogann Tolbatov, Damiano Cirri, Lorella Marchetti, Alessandro Marrone, Cecilia Coletti, Nazzareno Re, Diego La Mendola, Luigi Messori, Tiziano Marzo, Chiara Gabbiani, Alessandro Pratesi
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Au(PEt3)I (AF-I hereafter), the iodide analog of the FDA-approved drug auranofin (AF hereafter), is a promising anticancer agent that produces its pharmacological effects through interaction with non-genomic targets such as the thioredoxin reductase
Externí odkaz:
https://doaj.org/article/80d53dd7b0e24fbabdfa02fc233254b9
Autor:
Damiano Cirri, Tiziano Marzo, Iogann Tolbatov, Alessandro Marrone, Francesco Saladini, Ilaria Vicenti, Filippo Dragoni, Adele Boccuto, Luigi Messori
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1858 (2021)
Metal-based drugs represent a rich source of chemical substances of potential interest for the treatment of COVID-19. To this end, we have developed a small but representative panel of nine metal compounds, including both synthesized and commercially
Externí odkaz:
https://doaj.org/article/d845233acb5041cba0ec503d3f18e86b
Publikováno v:
Molecules, Vol 26, Iss 24, p 7600 (2021)
Owing to the growing hardware capabilities and the enhancing efficacy of computational methodologies, computational chemistry approaches have constantly become more important in the development of novel anticancer metallodrugs. Besides traditional Pt
Externí odkaz:
https://doaj.org/article/07bc930fb2924d77be452fd61f307f7a
Autor:
Iogann Tolbatov, Elisabetta Barresi, Sabrina Taliani, Diego La Mendola, Tiziano Marzo, Alessandro Marrone
Publikováno v:
Inorganic Chemistry Frontiers. 10:2226-2238
Diruthenium(ii,iii) paddlewheel carboxylates combine the pharmacological properties of the dimetallic center with those ascribed to the μ-bridged carboxylates, thus leading to novel, dual-acting anticancer metallodrugs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68898d73d9450e5277d8aa820f462be8
https://doi.org/10.1039/d3qi00157a
https://doi.org/10.1039/d3qi00157a
Autor:
Valentin Vaillant-Coindard, Benjamin Théron, Gaël Printz, Florian Chotard, Cédric Balan, Yoann Rousselin, Philippe Richard, Iogann Tolbatov, Paul Fleurat-Lessard, Ewen Bodio, Raluca Malacea-Kabbara, Jérôme Bayardon, Samuel Dagorne, Pierre Le Gendre
Publikováno v:
Organometallics. 41:2920-2932
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::229346a19e7858979f713d638f7f17a2
https://doi.org/10.1021/acs.organomet.2c00343
https://doi.org/10.1021/acs.organomet.2c00343
Publikováno v:
Inorganic Chemistry. 61:15664-15677
The identification of novel therapeutics against the pandemic SARS-CoV-2 infection is an indispensable new address of current scientific research. In the search for anti-SARS-CoV-2 agents as alternatives to the vaccine or immune therapeutics whose ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98138929b5f5a4927157dfb8185f8de
https://doi.org/10.1021/acs.inorgchem.2c02685
https://doi.org/10.1021/acs.inorgchem.2c02685
Autor:
Alessandro Marrone, Iogann Tolbatov
Publikováno v:
Pharmaceutics; Volume 15; Issue 3; Pages: 985
Recently, the well-characterized metallodrug auranofin has been demonstrated to restore the penicillin and cephalosporin sensitivity in resistant bacterial strains via the inhibition of the NDM-1 beta-lactamase, which is operated via the Zn/Au substi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3370203ef4b09366e0605a3cfab83a50