Výsledky vyhledávání - "Ioav Z. Cabantchik"

Akademický článek

A Combined Drug Treatment That Reduces Mitochondrial Iron and Reactive Oxygen Levels Recovers Insulin Secretion in NAF-1-Deficient Pancreatic Cells

Autor: Ola Karmi, Yang-Sung Sohn, Henri-Baptiste Marjault, Tal Israeli, Gil Leibowitz, Konstantinos Ioannidis, Yaakov Nahmias, Ron Mittler, Ioav Z. Cabantchik, Rachel Nechushtai

Publikováno v: Antioxidants, Vol 10, Iss 8, p 1160 (2021)

Decreased insulin secretion, associated with pancreatic β-cell failure, plays a critical role in many human diseases including diabetes, obesity, and cancer. While numerous studies linked β-cell failure with enhanced levels of reactive oxygen speci

Externí odkaz: https://doaj.org/article/445d18587fbe4b629ebd01f35f244779

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The [2Fe-2S] protein CISD2 plays a key role in preventing iron accumulation in cardiomyocytes

Autor: Ola Karmi, Linda Rowland, Skylar D. King, Camila Manrique‐Acevedo, Ioav Z. Cabantchik, Rachel Nechushtai, Ron Mittler

Publikováno v: FEBS lettersReferences. 596(6)

Considered a key aging gene, CISD2, encoding CDGSH iron-sulfur domain-containing protein 2, plays a central role in regulating calcium homeostasis, preventing mitochondrial dysfunction, and the activation of autophagy and apoptosis in different cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c93d5eb36413a0f9e775a2f232411c4
https://pubmed.ncbi.nlm.nih.gov/34997963

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