Deep learning of antibody epitopes using positional permutation vectors

Autor: Ioannis Vardaxis, Boris Simovski, Irantzu Anzar, Richard Stratford, Trevor Clancy

Publikováno v: Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2695-2707 (2024)

Background: The accurate computational prediction of B cell epitopes can vastly reduce the cost and time required for identifying potential epitope candidates for the design of vaccines and immunodiagnostics. However, current computational tools for

Externí odkaz: https://doaj.org/article/2693960953f94fd18bcf44205e276a37

The interplay between neoantigens and immune cells in sarcomas treated with checkpoint inhibition

Autor: Irantzu Anzar, Brandon Malone, Pubudu Samarakoon, Ioannis Vardaxis, Boris Simovski, Hugues Fontenelle, Leonardo A. Meza-Zepeda, Richard Stratford, Emily Z. Keung, Melissa Burgess, Hussein A. Tawbi, Ola Myklebost, Trevor Clancy

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionSarcomas are comprised of diverse bone and connective tissue tumors with few effective therapeutic options for locally advanced unresectable and/or metastatic disease. Recent advances in immunotherapy, in particular immune checkpoint inhi

Externí odkaz: https://doaj.org/article/53e7fb56ac8c4288a24bd58dd3d4124a

Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2 leading to universal blueprints for vaccine designs

Autor: Brandon Malone, Boris Simovski, Clément Moliné, Jun Cheng, Marius Gheorghe, Hugues Fontenelle, Ioannis Vardaxis, Simen Tennøe, Jenny-Ann Malmberg, Richard Stratford, Trevor Clancy

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)

Abstract The global population is at present suffering from a pandemic of Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The goal of this study was to use artificial

Externí odkaz: https://doaj.org/article/b6083f2efc1b428fbf2eba0c45005e9d

Assessing short-term risk of ischemic stroke in relation to all prescribed medications

Autor: Abhijit Sen, Imre Janszky, Linn B Strand, Pål Richard Romundstad, Kenneth J. Mukamal, Bo Henry Lindqvist, Jens W. Horn, Rickard Ljung, Ingvild Vatten Alsnes, Ben Michael Brumpton, Ioannis Vardaxis, Inger Johanne Bakken

Publikováno v: Scientific Reports
21673 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

We examined the short-term risk of stroke associated with drugs prescribed in Norway or Sweden in a comprehensive, hypothesis-free manner using comprehensive nation-wide data. We identified 27,680 and 92,561 cases with a first ischemic stroke via the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2b64a20c9a770e86049239d10d8f39
https://hdl.handle.net/11250/2829784

Systematic assessment of prescribed medications and short-term risk of myocardial infarction – a pharmacopeia-wide association study from Norway and Sweden

Autor: Rickard Ljung, Imre Janszky, Bo Henry Lindqvist, Ioannis Vardaxis, Kenneth J. Mukamal, Linn B Strand, Abhijit Sen, Lars J. Vatten, Inger Johanne Bakken, Pål Richard Romundstad, Ben Michael Brumpton

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Sen, A, Vardaxis, I, Lindqvist, B H, Brumpton, B M, Strand, L B, Bakken, I J, Vatten, L J, Romundstad, P R, Ljung, R, Mukamal, K J & Janszky, I 2019, ' Systematic assessment of prescribed medications and short-term risk of myocardial infarction – a pharmacopeia-wide association study from Norway and Sweden ', Scientific Reports, vol. 9, 8257 . https://doi.org/10.1038/s41598-019-44641-1

Wholesale, unbiased assessment of Scandinavian electronic health-care databases offer a unique opportunity to reveal potentially important undiscovered drug side effects. We examined the short-term risk of acute myocardial infarction (AMI) associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3dec106358fb657b39cc66ee2a5931
https://doi.org/10.1038/s41598-019-44641-1