Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Ioannis Vakonakis"'
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-9 (2019)
Abstract Background Malaria kills over 400,000 people each year and nearly half the world’s population live in at-risk areas. Progress against malaria has recently stalled, highlighting the need for developing novel therapeutics. The parasite haemo
Externí odkaz:
https://doaj.org/article/72c535a16d294ed9805a317e3be952a2
Autor:
Eva Hitz, Natalie Wiedemar, Armin Passecker, Beatriz A S Graça, Christian Scheurer, Sergio Wittlin, Nicolas M B Brancucci, Ioannis Vakonakis, Pascal Mäser, Till S Voss
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001483 (2021)
Cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) signalling is essential for the proliferation of Plasmodium falciparum malaria blood stage parasites. The mechanisms regulating the activity of the catalytic subunit PfPKAc, howev
Externí odkaz:
https://doaj.org/article/413e0f8e7b194959ad8aefaffac57cbd
Autor:
Erin E Cutts, Niklas Laasch, Dirk M Reiter, Raphael Trenker, Leanne M Slater, Phillip J Stansfeld, Ioannis Vakonakis
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006552 (2017)
Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) and Knob-associated Histidine-rich Protein (KAHRP) are directly linked to malaria pathology. PfEMP1 and KAHRP cluster on protrusions (knobs) on the P. falciparum-infected erythrocyte surfa
Externí odkaz:
https://doaj.org/article/97e05a91c1c54289b5b586d310981f6f
Autor:
Simone Prömel, Marie Frickenhaus, Samantha Hughes, Lamia Mestek, David Staunton, Alison Woollard, Ioannis Vakonakis, Torsten Schöneberg, Ralf Schnabel, Andreas P. Russ, Tobias Langenhan
Publikováno v:
Cell Reports, Vol 2, Iss 2, Pp 321-331 (2012)
Adhesion class G protein-coupled receptors (aGPCR) form the second largest group of seven-transmembrane-spanning (7TM) receptors whose molecular layout and function differ from canonical 7TM receptors. Despite their essential roles in immunity, tumor
Externí odkaz:
https://doaj.org/article/d46d010d9fbc404a8102cca8d868f516
Autor:
Kacper B Rogala, Nicola J Dynes, Georgios N Hatzopoulos, Jun Yan, Sheng Kai Pong, Carol V Robinson, Charlotte M Deane, Pierre Gönczy, Ioannis Vakonakis
Publikováno v:
eLife, Vol 4 (2015)
Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional equivalents across eukaryoti
Externí odkaz:
https://doaj.org/article/0e80467546c64fd58532816d5aa97d81
Autor:
Mila M Paul, Sven Dannhäuser, Lydia Morris, Achmed Mrestani, Martha Hübsch, Jennifer Gehring, Georgios N Hatzopoulos, Martin Pauli, Genevieve M Auger, Grit Bornschein, Nicole Scholz, Dmitrij Ljaschenko, Martin Müller, Markus Sauer, Hartmut Schmidt, Robert J Kittel, Aaron DiAntonio, Ioannis Vakonakis, Manfred Heckmann, Tobias Langenhan
Publikováno v:
Brain. 145:3787-3802
Humans carrying the CORD7 (cone-rod dystrophy 7) mutation possess increased verbal IQ and working memory. This autosomal dominant syndrome is caused by the single-amino acid R844H exchange (human numbering) located in the 310 helix of the C2A domain
Autor:
Funso E. Ogunmolu, Shoeib Moradi, Vladimir A. Volkov, Chris van Hoorn, Jingchao Wu, Nemo Andrea, Shasha Hua, Kai Jiang, Ioannis Vakonakis, Mia Potočnjak, Franz Herzog, Benoît Gigant, Nikita Gudimchuk, Kelly E. Stecker, Marileen Dogterom, Michel O. Steinmetz, Anna Akhmanova
Centrioles are microtubule-based organelles required for the formation of centrosomes and cilia. Centriolar microtubules, unlike their cytosolic counterparts, grow very slowly and are very stable. The complex of centriolar proteins CP110 and CEP97 fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de8d383db4a0caec7578f292fc79fd3
https://hal.science/hal-03829938
https://hal.science/hal-03829938
Centrioles are eukaryotic organelles that template the formation of cilia and flagella, as well as organize the microtubule network and the mitotic spindle in animal cells. Centrioles have proximal-distal polarity and a 9 fold radial symmetry imparte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3294f9a9f5c153468751966b761681e
https://ora.ox.ac.uk/objects/uuid:962c734b-b235-474f-8c20-980e7520e699
https://ora.ox.ac.uk/objects/uuid:962c734b-b235-474f-8c20-980e7520e699
Autor:
Julia Schmidt, Ioannis Vakonakis
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
The 3.25 Å resolution crystallographic structure of the substrate-binding domain of the erythrocyte-exported Hsp70 chaperone from the malaria parasite Plasmodium falciparum was determined. The parasite domain is shown to be highly similar to the equ
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
233 chemical fragments were screened for binding to the ATPase domain of the Hsp70-x chaperone from the malaria parasite Plasmodium falciparum. Crystallographic structures of this domain in complex with different fragments revealed a major binding si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9cd9a07ab9ac2627c835caa0839475
https://ora.ox.ac.uk/objects/uuid:5383eaa1-e05e-4c74-9970-2f3b33e10116
https://ora.ox.ac.uk/objects/uuid:5383eaa1-e05e-4c74-9970-2f3b33e10116