Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Ioannis P. Nezis"'
Autor:
Vladimir V. Rogov, Ioannis P. Nezis, Panagiotis Tsapras, Hong Zhang, Yasin Dagdas, Nobuo N. Noda, Hitoshi Nakatogawa, Martina Wirth, Stephane Mouilleron, David G. McEwan, Christian Behrends, Vojo Deretic, Zvulun Elazar, Sharon A. Tooze, Ivan Dikic, Trond Lamark, Terje Johansen
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also emerging. Here, we review the
Externí odkaz:
https://doaj.org/article/efb1c686968d4bd0982e2069b219cc78
Autor:
Yan Zhang, Ioannis P. Nezis
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101830- (2022)
Summary: LIR motif-containing proteins (LIRCPs) bind to LDS (LIR motif docking site) of Atg8-family proteins. In this protocol, we describe steps to identify Drosophila LIRCPs, in Atg8a LDS mutants we have created, via label-free quantitative proteom
Externí odkaz:
https://doaj.org/article/874c31ebfda84193ba3d473826d102d2
Autor:
Amanda Demeter, Anne-Claire Jacomin, Lejla Gul, Ashleigh Lister, James Lipscombe, Rachele Invernizzi, Priscilla Branchu, Iain Macaulay, Ioannis P. Nezis, Robert A. Kingsley, Tamas Korcsmaros, Isabelle Hautefort
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Macroautophagy is a ubiquitous homeostasis and health-promoting recycling process of eukaryotic cells, targeting misfolded proteins, damaged organelles and intracellular infectious agents. Some intracellular pathogens such as Salmonella enterica sero
Externí odkaz:
https://doaj.org/article/2473b25ba8984379ac6d561d72fc768c
Autor:
Panagiotis Tsapras, Stavroula Petridi, Selina Chan, Marta Geborys, Anne-Claire Jacomin, Antonia P. Sagona, Pascal Meier, Ioannis P. Nezis
Publikováno v:
Cell Reports, Vol 38, Iss 4, Pp 110286- (2022)
Summary: Selective autophagy is a catabolic route that turns over specific cellular material for degradation by lysosomes, and whose role in the regulation of innate immunity is largely unexplored. Here, we show that the apical kinase of the Drosophi
Externí odkaz:
https://doaj.org/article/7bcd2a950cbc4ddd993881f146b2b3de
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9228 (2022)
The beneficial effects of diet and exercise on brain function are traditionally attributed to the enhancement of autophagy, which plays a key role in neuroprotection via the degradation of potentially harmful intracellular structures. The molecular m
Externí odkaz:
https://doaj.org/article/04728c549c3f448198c6bfbb1112a509
Autor:
Anne-Claire Jacomin, Stavroula Petridi, Marisa Di Monaco, Zambarlal Bhujabal, Ashish Jain, Nitha C. Mulakkal, Anthimi Palara, Emma L. Powell, Bonita Chung, Cleidiane Zampronio, Alexandra Jones, Alexander Cameron, Terje Johansen, Ioannis P. Nezis
Publikováno v:
Cell Reports, Vol 31, Iss 8, Pp - (2020)
Summary: Autophagy is the degradation of cytoplasmic material through the lysosomal pathway. One of the most studied autophagy-related proteins is LC3. Despite growing evidence that LC3 is enriched in the nucleus, its nuclear role is poorly understoo
Externí odkaz:
https://doaj.org/article/4c659952edc443cfb7875849b87d2315
Autor:
Anne-Claire Jacomin, Ioannis P. Nezis
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 1 (2020)
Implication of autophagy in the downregulation of immune signaling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction of Drosophila protein Kenny/IKKγ (
Externí odkaz:
https://doaj.org/article/36f82c96453d41e18f0a27c1d1f4fde7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2020)
Externí odkaz:
https://doaj.org/article/b96491dad05845e4a7d0c7b327be8371
Autor:
Radu Tusco, Anne-Claire Jacomin, Ashish Jain, Bridget S. Penman, Kenneth Bowitz Larsen, Terje Johansen, Ioannis P. Nezis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Selective autophagy describes the selective degradation of cellular components upon stress or nutrient deficiency, but whether it modulates innate immunity is unclear. Here the authors show that Drosophila Kenny may be an evolution-selected autophagy
Externí odkaz:
https://doaj.org/article/81ed953ad9ea48a8980dd1e3764b1e04
Autor:
Anne-Claire Jacomin, Kalotina Geraki, Jake Brooks, Vindy Tjendana-Tjhin, Joanna F. Collingwood, Ioannis P. Nezis
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Biometals such as iron, copper, potassium, and zinc are essential regulatory elements of several biological processes. The homeostasis of biometals is often affected in age-related pathologies. Notably, impaired iron metabolism has been linked to sev
Externí odkaz:
https://doaj.org/article/7392bc740420419497fc1622152c6f83