Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ioannis N. Melas"'
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128411 (2015)
Modeling of signal transduction pathways is instrumental for understanding cells' function. People have been tackling modeling of signaling pathways in order to accurately represent the signaling events inside cells' biochemical microenvironment in a
Externí odkaz:
https://doaj.org/article/5ee70dabf6de4fe1abc831e3ad18ae3e
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 9, p e1003204 (2013)
Cross-referencing experimental data with our current knowledge of signaling network topologies is one central goal of mathematical modeling of cellular signal transduction networks. We present a new methodology for data-driven interrogation and train
Externí odkaz:
https://doaj.org/article/d05b65a77f9c41a7871591f97ddb098b
Autor:
Alexander Mitsos, Ioannis N Melas, Melody K Morris, Julio Saez-Rodriguez, Douglas A Lauffenburger, Leonidas G Alexopoulos
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50085 (2012)
Modeling of signal transduction pathways plays a major role in understanding cells' function and predicting cellular response. Mathematical formalisms based on a logic formalism are relatively simple but can describe how signals propagate from one pr
Externí odkaz:
https://doaj.org/article/6400e8b0d55544899ecc443d2128410c
Autor:
Alexander Mitsos, Ioannis N Melas, Paraskeuas Siminelakis, Aikaterini D Chairakaki, Julio Saez-Rodriguez, Leonidas G Alexopoulos
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 12, p e1000591 (2009)
Understanding the mechanisms of cell function and drug action is a major endeavor in the pharmaceutical industry. Drug effects are governed by the intrinsic properties of the drug (i.e., selectivity and potency) and the specific signaling transductio
Externí odkaz:
https://doaj.org/article/ebcdb05c4632494f9419a90f5c22a618
Publikováno v:
Expert Opinion on Drug Discovery. 13:1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721e400af351d1d3d7266b3f5f252811
https://doi.org/10.1080/17460441.2018.1394839
https://doi.org/10.1080/17460441.2018.1394839
Autor:
Ioannis N, Melas, Theodore, Sakellaropoulos, Junguk, Hur, Dimitris, Messinis, Ellen Y, Guo, Leonidas G, Alexopoulos, Jane P F, Bai
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1939
In the era of big data and informatics, computational integration of data across the hierarchical structures of human biology enables discovery of new druggable targets of disease and new mode of action of a drug. We present herein a computational fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7063783f0eaaed70f8d4a8eda3ce5533
https://pubmed.ncbi.nlm.nih.gov/30848462
https://pubmed.ncbi.nlm.nih.gov/30848462
Autor:
Jane P.F. Bai, Junguk Hur, Leonidas G. Alexopoulos, Dimitris E Messinis, Ellen Y. Guo, Ioannis N. Melas, Theodore Sakellaropoulos
Publikováno v:
Methods in Molecular Biology ISBN: 9781493990887
In the era of big data and informatics, computational integration of data across the hierarchical structures of human biology enables discovery of new druggable targets of disease and new mode of action of a drug. We present herein a computational fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::405cc7461252620f8fd806517afd29d6
https://doi.org/10.1007/978-1-4939-9089-4_10
https://doi.org/10.1007/978-1-4939-9089-4_10
Autor:
Leonidas G. Alexopoulos, Dimitris E Messinis, Fragiskos N. Kolisis, Steffen Klamt, Heleni Loutrari, Ioannis N. Melas, Maria Michailidou
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 4:350-361
Chronic inflammation is associated with the development of human hepatocellular carcinoma (HCC), an essentially incurable cancer. Anti-inflammatory nutraceuticals have emerged as promising candidates against HCC, yet the mechanisms through which they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5d853f6e73ce253ad1f85a928f0bd4c
https://doi.org/10.1002/psp4.40
https://doi.org/10.1002/psp4.40
Autor:
Jane P.F. Bai, Ioannis N. Melas, Navya Varshney, Junguk Hur, Leonidas G. Alexopoulos, Dimitris E Messinis
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Drug-induced cardiomyopathy contributes to drug attrition. We compared two pipelines of predictive modeling: (1) applying elastic net (EN) to differentially expressed genes (DEGs) of drugs; (2) applying integer linear programming (ILP) to construct e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8892d73ff55d6c33397dd97eb5f4da34
https://pubmed.ncbi.nlm.nih.gov/29341478
https://pubmed.ncbi.nlm.nih.gov/29341478
Autor:
Leonidas G. Alexopoulos, Tomas Olsson, Roland Martin, Elena Schwartz, Ekaterina Kotelnikova, Ioannis N. Melas, Julio Saez-Rodriguez, P. Villoslada, Friedemann Paul, Albert Zamora, Jose Manuel Mas, Laura Artigas, Jesper Tegnér, Gilad Silberberg, Dimitris E Messinis, Ilya Mazo, Narsis A. Kiani, Mar Masso, Marti Bernardo-Faura
Publikováno v:
Multiple Sclerosis Journal
The pathogenesis of multiple sclerosis (MS) involves alterations to multiple pathways and processes, which represent a significant challenge for developing more-effective therapies. Systems biology approaches that study pathway dysregulation should o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09e031755f559e4c3ebc1c81167c63c