The Histone Deacetylase 9 Stroke-Risk Variant Promotes Apoptosis and Inflammation in a Human iPSC-Derived Smooth Muscle Cells Model

Autor: Alessandra Granata, Ioannis Kasioulis, Felipe Serrano, James D. Cooper, Matthew Traylor, Sanjay Sinha, Hugh S. Markus

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

A common variant in the Histone Deacetylase 9 (HDAC9) gene is the strongest genetic risk for large-vessel stroke, and HDAC9 offers a novel target for therapeutic modulation. However, the mechanisms linking the HDAC9 variant with increased stroke risk

Externí odkaz: https://doaj.org/article/be8fb247debe4d449c933c6d5f7b9b5c

Pleiotropic effects of Sox2 during the development of the zebrafish epithalamus.

Autor: Sofia Pavlou, Katy Astell, Ioannis Kasioulis, Milica Gakovic, Richard Baldock, Veronica van Heyningen, Pedro Coutinho

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e87546 (2014)

The zebrafish epithalamus is part of the diencephalon and encompasses three major components: the pineal, the parapineal and the habenular nuclei. Using sox2 knockdown, we show here that this key transcriptional regulator has pleiotropic effects duri

Externí odkaz: https://doaj.org/article/a3754b0f6c874e88bdae23fa2955d6ff

Cell biological mechanisms regulating chick neurogenesis

Autor: Ioannis Kasioulis, Kate G. Storey

Publikováno v: The International Journal of Developmental Biology. 62:167-175

Signalling pathways that regulate neural progenitor proliferation and neuronal differentiation have been identified. However, we know much less about how transduction of such signals is regulated within neuroepithelial cells to direct cell fate choic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edaa7df91ca12fb18f73c92a56a6d42f
https://doi.org/10.1387/ijdb.170268ks

Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis

Autor: Andrew J. Finch, Ioannis Kasioulis, Catherine H. Botting, Anne Seawright, Peri Tate, Veronica van Heyningen, Joseph Shaw, Sally L. Shirran, Matthew Fuszard, Patricia L. Yeyati, Ian R. Adams, Ian J. Jackson, Heather M. Syred

Publikováno v: Kasioulis, I, Syred, H M, Tate, P, Finch, A, Shaw, J, Seawright, A, Fuszard, M, Botting, C H, Shirran, S, Adams, I R, Jackson, I J, Van Heyningen, V & Yeyati, P L 2014, ' Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis ', Molecular Biology of the Cell, vol. 25, no. 8, pp. 1216-1233 . https://doi.org/10.1091/mbc.E13-08-0471
Molecular Biology of the Cell

Chromatin remodeling enzymes can also have nonhistone roles, broadening their biological functions. It is shown that Kdm3a binding to cellular chaperones in the cytoplasm is relevant for morphogenetic events leading to infertility in enzymatically nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef5f8251f9eb7ef680e108fd3289e22
https://doi.org/10.1091/mbc.e13-08-0471

Pleiotropic effects of Sox2 during the development of the zebrafish epithalamus

Autor: Richard Baldock, Sofia Pavlou, Pedro Coutinho, Katy R. Astell, Veronica van Heyningen, Milica Gakovic, Ioannis Kasioulis

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e87546 (2014)
PLoS ONE
Pavlou, S, Astell, K, Kasioulis, I, Gakovic, M, Baldock, R, van Heyningen, V & Coutinho, P 2014, ' Pleiotropic Effects of Sox2 during the Development of the Zebrafish Epithalamus ', PLoS ONE, vol. 9, no. 1, pp. e87546 . https://doi.org/10.1371/journal.pone.0087546

The zebrafish epithalamus is part of the diencephalon and encompasses three major components: the pineal, the parapineal and the habenular nuclei. Using sox2 knockdown, we show here that this key transcriptional regulator has pleiotropic effects duri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2050dee2e98cc1a789a4a896d075abe7
http://europepmc.org/articles/PMC3909122?pdf=render