Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ioannis Galdadas"'
Autor:
R. Sumanth Iyer, Sarah R. Needham, Ioannis Galdadas, Benjamin M. Davis, Selene K. Roberts, Rico C. H. Man, Laura C. Zanetti-Domingues, David T. Clarke, Gilbert O. Fruhwirth, Peter J. Parker, Daniel J. Rolfe, Francesco L. Gervasio, Marisa L. Martin-Fernandez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The Epidermal Growth Factor Receptor (EGFR) is frequently found to be mutated in non-small cell lung cancer. Oncogenic EGFR has been successfully targeted by tyrosine kinase inhibitors, but acquired drug resistance eventually overcomes the e
Externí odkaz:
https://doaj.org/article/85aaaaecf9114b44adb21e316e7276e8
Autor:
Lydia Wehrli, Ioannis Galdadas, Lionel Voirol, Martin Smieško, Yves Cambet, Vincent Jaquet, Stéphane Guerrier, Francesco Luigi Gervasio, Serge Nef, Rita Rahban
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The sperm-specific channel CatSper (cation channel of sperm) controls the intracellular Ca2+ concentration ([Ca2+]i) and plays an essential role in sperm function. It is mainly activated by the steroid progesterone (P4) but is also promiscuously acti
Externí odkaz:
https://doaj.org/article/615465c0b9f74934804518fb5b8517a1
Autor:
Alberto Borsatto, Obaeda Akkad, Ioannis Galdadas, Shumeng Ma, Shymaa Damfo, Shozeb Haider, Frank Kozielski, Carolina Estarellas, Francesco Luigi Gervasio
Publikováno v:
eLife, Vol 11 (2022)
Non-structural protein 1 (Nsp1) is a main pathogenicity factor of α- and β-coronaviruses. Nsp1 of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suppresses the host gene expression by sterically blocking 40S host ribosomal subunits an
Externí odkaz:
https://doaj.org/article/bb41995f76cd4784b965708fe465be40
Autor:
Sten Ilmjärv, Fabien Abdul, Silvia Acosta-Gutiérrez, Carolina Estarellas, Ioannis Galdadas, Marina Casimir, Marco Alessandrini, Francesco Luigi Gervasio, Karl-Heinz Krause
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The D614G mutation in the Spike protein of the SARS-CoV-2 has effectively replaced the early pandemic-causing variant. Using pseudotyped lentivectors, we confirmed that the aspartate replacement by glycine in position 614 is markedly more in
Externí odkaz:
https://doaj.org/article/425fb19c933a4ad18acbebcbf3e961d0
Autor:
Ioannis Galdadas, Luca Carlino, Richard A Ward, Samantha J Hughes, Shozeb Haider, Francesco Luigi Gervasio
Publikováno v:
eLife, Vol 10 (2021)
Mutations within the kinase domain of the epidermal growth factor receptor (EGFR) are common oncogenic driver events in non-small cell lung cancer. Although the activation of EGFR in normal cells is primarily driven by growth-factor-binding-induced d
Externí odkaz:
https://doaj.org/article/81dc61c28a954436915e6a9fe3501b61
Autor:
Ioannis Galdadas, Shen Qu, Ana Sofia F Oliveira, Edgar Olehnovics, Andrew R Mack, Maria F Mojica, Pratul K Agarwal, Catherine L Tooke, Francesco Luigi Gervasio, James Spencer, Robert A Bonomo, Adrian J Mulholland, Shozeb Haider
Publikováno v:
eLife, Vol 10 (2021)
Understanding allostery in enzymes and tools to identify it offer promising alternative strategies to inhibitor development. Through a combination of equilibrium and nonequilibrium molecular dynamics simulations, we identify allosteric effects and co
Externí odkaz:
https://doaj.org/article/7aac1beac51a40888c31f6d01e330204
Autor:
Melissa D. Barnes, Magdalena A. Taracila, Joseph D. Rutter, Christopher R. Bethel, Ioannis Galdadas, Andrea M. Hujer, Emilia Caselli, Fabio Prati, John P. Dekker, Krisztina M. Papp-Wallace, Shozeb Haider, Robert A. Bonomo
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Pseudomonas aeruginosa produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam an
Externí odkaz:
https://doaj.org/article/edb8dbd7a6454ff080c0150b5085a0a8
Autor:
Alberto Borsatto, Obaeda Akkad, Ioannis Galdadas, Shumeng Ma, Shymaa Damfo, Shozeb Haider, Frank Kozielski, Carolina Estarellas, Francesco Luigi Gervasio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::822c0f6eed5b5410272ee6471e6c4c51
https://doi.org/10.7554/elife.81167.sa2
https://doi.org/10.7554/elife.81167.sa2
Autor:
Karl-Heinz Krause, Marco Alessandrini, Silvia Acosta-Gutierrez, Carolina Estarellas, Sten Ilmjärv, Francesco Luigi Gervasio, Fabien Abdul, Marina Casimir, Ioannis Galdadas
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific reports, Vol. 11, No 1 (2021) P. 13705
Scientific Reports
Scientific reports, Vol. 11, No 1 (2021) P. 13705
Scientific Reports
The D614G mutation in the Spike protein of the SARS-CoV-2 has effectively replaced the early pandemic-causing variant. Using pseudotyped lentivectors, we confirmed that the aspartate replacement by glycine in position 614 is markedly more infectious.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cf81c070a3769f43f996cff712616c
https://doaj.org/article/425fb19c933a4ad18acbebcbf3e961d0
https://doaj.org/article/425fb19c933a4ad18acbebcbf3e961d0
Autor:
Pauline Juyoux, Ioannis Galdadas, Dorothea Gobbo, Jill von Velsen, Martin Pelosse, Mark Tully, Oscar Vadas, Francesco Luigi Gervasio, Erika Pellegrini, Matthew W. Bowler
The MAP kinase p38α is a central component of signalling in inflammation and the immune response and is, therefore, an important drug target. Little is known about the molecular mechanism of its activation by double-phosphorylation from MAP2Ks, due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::952442b3cd813c8458b96c3e182e10b9
https://doi.org/10.1101/2022.07.04.498667
https://doi.org/10.1101/2022.07.04.498667