Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ioannis, Gelis"'
Autor:
Michael D Sacco, Lauren R Hammond, Radwan E Noor, Dipanwita Bhattacharya, Lily J McKnight, Jesper J Madsen, Xiujun Zhang, Shane G Butler, M Trent Kemp, Aiden C Jaskolka-Brown, Sebastian J Khan, Ioannis Gelis, Prahathees Eswara, Yu Chen
Publikováno v:
eLife, Vol 13 (2024)
In the Firmicutes phylum, GpsB is a membrane associated protein that coordinates peptidoglycan synthesis with cell growth and division. Although GpsB has been studied in several bacteria, the structure, function, and interactome of Staphylococcus aur
Externí odkaz:
https://doaj.org/article/bfed07d8cbee49deab96202e09ac50e1
Autor:
Michael D. Sacco, Shaohui Wang, Swamy R. Adapa, Xiujun Zhang, Eric M. Lewandowski, Maura V. Gongora, Dimitra Keramisanou, Zachary D. Atlas, Julia A. Townsend, Jean R. Gatdula, Ryan T. Morgan, Lauren R. Hammond, Michael T. Marty, Jun Wang, Prahathees J. Eswara, Ioannis Gelis, Rays H. Y. Jiang, Xingmin Sun, Yu Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Antibiotics of the β-lactam class inhibit bacterial cell wall synthesis by targeting penicillin-binding proteins (PBPs). Here, Sacco et al. study the four PBPs present in the pathogen C. difficile, revealing unique structural features and shedding l
Externí odkaz:
https://doaj.org/article/ab479e50342c4a208865cf0e9e27f5cd
Autor:
Wanping Xu, Kristin Beebe, Juan D. Chavez, Marta Boysen, YinYing Lu, Abbey D. Zuehlke, Dimitra Keramisanou, Jane B. Trepel, Christosomos Prodromou, Matthias P. Mayer, James E. Bruce, Ioannis Gelis, Len Neckers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Phosphorylation of Tyr313 in Hsp90 enhances the binding to its activator Aha1, but the underlying mechanism is unknown. Here, the authors study the structural consequences of Tyr313 phosphorylation, showing that it serves as a conformational switch i
Externí odkaz:
https://doaj.org/article/c98ae81e4f7740939a33040bfaf94c2e
Autor:
Ashleigh B. Bachman, Dimitra Keramisanou, Wanping Xu, Kristin Beebe, Michael A. Moses, M. V. Vasantha Kumar, Geoffrey Gray, Radwan Ebna Noor, Arjan van der Vaart, Len Neckers, Ioannis Gelis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The Hsp90 chaperone cycle is influenced by multiple phosphorylation events but their regulatory functions are poorly understood. Here, the authors show that phosphorylation and unfolding of cochaperone Cdc37 tailors the Hsp90 chaperone cycle by recru
Externí odkaz:
https://doaj.org/article/1ad30120ac2049d29abb8f3ab36b01ec
Autor:
Michael D. Sacco, Lauren R. Hammond, Radwan E. Noor, Dipanwita Bhattacharya, Jesper J. Madsen, Xiujun Zhang, Shane G. Butler, M. Trent Kemp, Aiden C. Jaskolka-Brown, Sebastian J. Khan, Ioannis Gelis, Prahathees J. Eswara, Yu Chen
Bacterial cell division is a tightly regulated process that requires the formation of a dynamic multi-protein complex. In the Firmicutes phylum, GpsB is a membrane associated protein that coordinates peptidoglycan synthesis for cell growth and divisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0c2d8b9c6e1d181b8709ade21ca036
https://doi.org/10.1101/2022.10.25.513704
https://doi.org/10.1101/2022.10.25.513704
Autor:
Adam A Aboalroub, Ashleigh B Bachman, Ziming Zhang, Dimitra Keramisanou, David J Merkler, Ioannis Gelis
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177270 (2017)
The transfer of an acetyl group from acetyl-CoA to an acceptor amine is a ubiquitous biochemical transformation catalyzed by Gcn5-related N-acetyltransferases (GNATs). Although it is established that the reaction proceeds through a sequential ordered
Externí odkaz:
https://doaj.org/article/ae15601347b4436b93c0145d219e22bc
Publikováno v:
Science advances. 8(11)
Molecular chaperones have an essential role for the maintenance of a balanced protein homeostasis. Here, we investigate how protein kinases are recruited and loaded to the Hsp90-Cdc37 complex, the first step during Hsp90-mediated chaperoning that lea
Autor:
M V Vasantha Kumar, Radwan Ebna Noor, Ioannis Gelis, Ruslan Sanishvili, Orville A. Pemberton, H. Lee Woodcock, M. Trent Kemp, Yu Chen, Fiona L. Kearns
Publikováno v:
Proc Natl Acad Sci U S A
Gram-negative bacteria expressing class A β-lactamases pose a serious health threat due to their ability to inactivate all β-lactam antibiotics. The acyl–enzyme intermediate is a central milestone in the hydrolysis reaction catalyzed by these enz
Autor:
Gabriela Suarez, Eric M. Lewandowski, Yu Chen, David J. Merkler, Nasha M Rios-Guzman, Karin Claire Prins, Ioannis Gelis, Britney A. Shepherd, James W. Leahy, Ryan L. Anderson, Angelica N McCaskey, Brian G. O'Flynn
Publikováno v:
ACS Chemical Biology. 15:513-523
The growing issue of insecticide resistance has meant the identification of novel insecticide targets has never been more important. Arylalkylamine N-acyltransferases (AANATs) have been suggested as a potential new target. These promiscuous enzymes a
Autor:
Abbey D. Zuehlke, YinYing Lu, Dimitra Keramisanou, Ioannis Gelis, Juan D. Chavez, Wanping Xu, Matthias P. Mayer, James E. Bruce, Len Neckers, Marta Boysen, Christosomos Prodromou, Jane B. Trepel, Kristin Beebe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Complex conformational dynamics are essential for function of the dimeric molecular chaperone heat shock protein 90 (Hsp90), including transient, ATP-biased N-domain dimerization that is necessary to attain ATPase competence. The intrinsic, but weak,