Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

Autor: Clémence Mooser, Ioanna-Eleni Symeonidou, Pia-Amata Leimbacher, Alison Ribeiro, Ann-Marie K. Shorrocks, Stephanie Jungmichel, Sara C. Larsen, Katja Knechtle, Arti Jasrotia, Diana Zurbriggen, Alain Jeanrenaud, Colin Leikauf, Daniel Fink, Michael L. Nielsen, Andrew N. Blackford, Manuel Stucki

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

DNA double-strand breaks in ribosomal DNA repeats is associated with repression of ribosomal RNA synthesis. Here the authors reveal a cooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibition and nucleol

Externí odkaz: https://doaj.org/article/1e40f7a690df46ba8c9721ca498fe614

Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

Autor: Alain Jeanrenaud, Michael L. Nielsen, Clémence Mooser, Ioanna-Eleni Symeonidou, Colin Leikauf, Katja Knechtle, Arti Jasrotia, Alison Ribeiro, Ann-Marie K. Shorrocks, Diana Zurbriggen, Daniel Fink, Pia-Amata Leimbacher, Andrew N. Blackford, Manuel Stucki, Sara Larsen, Stephanie Jungmichel

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Mooser, C, Symeonidou, I-E, Leimbacher, P-A, Ribeiro, A, Shorrocks, A-M K, Jungmichel, S, Larsen, S C, Knechtle, K, Jasrotia, A, Zurbriggen, D, Jeanrenaud, A, Leikauf, C, Fink, D, Nielsen, M L, Blackford, A N & Stucki, M 2020, ' Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation ', Nature Communications, vol. 11, 123 . https://doi.org/10.1038/s41467-019-13981-x
Nature Communications

Induction of DNA double-strand breaks (DSBs) in ribosomal DNA (rDNA) repeats is associated with ATM-dependent repression of ribosomal RNA synthesis and large-scale reorganization of nucleolar architecture, but the signaling events that regulate these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f157e37d2113ae3a5e8ebc159422ae8d
http://ora.ox.ac.uk/objects/uuid:

Idas, a Novel Phylogenetically Conserved Geminin-related Protein, Binds to Geminin and Is Required for Cell Cycle Progression

Autor: Dafni-Eleutheria Pefani, Maria Dimaki, Ioanna-Eleni Symeonidou, Christina Kyrousi, Magda Spella, Zoi Lygerou, Nickolas Karantzelis, Stavros Taraviras, Anastassis Perrakis, Eirini Mitsiki

Publikováno v: Journal of Biological Chemistry. 286:23234-23246

Development and homeostasis of multicellular organisms relies on an intricate balance between cell proliferation and differentiation. Geminin regulates the cell cycle by directly binding and inhibiting the DNA replication licensing factor Cdt1. Gemin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a45618d42e1b3a2f6d58131937c574e
https://doi.org/10.1074/jbc.m110.207688

Cell cycle-dependent subcellular translocation of the human DNA licensing inhibitor geminin

Autor: Maria Dimaki, Ioanna Eleni Symeonidou, Hideo Nishitani, Chaido Sirinian, Georgia Xouri, Stavros Taraviras, Zoi Lygerou

Publikováno v: Journal of Biological Chemistry

Once per cell cycle replication is crucial for maintaining genome integrity. Geminin interacts with the licensing factor Cdt1 to prevent untimely replication and is controlled by APC/C-dependent cell cycle specific proteolysis during mitosis and in G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5ea1fc6245192c83b77672b3a141b7

Licensing of DNA replication, cancer, pluripotency and differentiation: An interlinked world?

Autor: Nikolaos I. Kanellakis, Zoi Lygerou, P. Nikolopoulou, S. Champeris Tsaniras, Ioanna-Eleni Symeonidou, Stavros Taraviras

Publikováno v: Seminars in Cell & Developmental Biology. :174-180

Recent findings provide evidence for a functional interplay between DNA replication and the seemingly distinct areas of cancer, development and pluripotency. Protein complexes participating in DNA replication origin licensing are now known to have ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c293597684007b8e0d18911a38a707