Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ioanna Ledaki"'
Autor:
Adrian L. Harris, Pawel Swietach, Richard D. Vaughan-Jones, William S. Sly, Kevin Gatter, Cameron Snell, Russell Leek, Helen Turley, Ioanna Ledaki, Ji-liang Li, Simon Wigfield, Shalini Patiar, Alan McIntyre
(72 KB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdc789bf64d005a58a39783951b9ca3
https://doi.org/10.1158/1078-0432.22443911
https://doi.org/10.1158/1078-0432.22443911
Autor:
Adrian L. Harris, Pawel Swietach, Richard D. Vaughan-Jones, William S. Sly, Kevin Gatter, Cameron Snell, Russell Leek, Helen Turley, Ioanna Ledaki, Ji-liang Li, Simon Wigfield, Shalini Patiar, Alan McIntyre
Purpose: Bevacizumab, an anti-VEGFA antibody, inhibits the developing vasculature of tumors, but resistance is common. Antiangiogenic therapy induces hypoxia and we observed increased expression of hypoxia-regulated genes, including carbonic anhydras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44ccc35304b124147cf4893c476a8a3
https://doi.org/10.1158/1078-0432.c.6520010.v1
https://doi.org/10.1158/1078-0432.c.6520010.v1
Autor:
Adrian L. Harris, Pawel Swietach, Richard D. Vaughan-Jones, William S. Sly, Kevin Gatter, Cameron Snell, Russell Leek, Helen Turley, Ioanna Ledaki, Ji-liang Li, Simon Wigfield, Shalini Patiar, Alan McIntyre
(1543 KB) - Analysis of the viable tumour volume at the first endpoint of the HCT116 and HT29 xenograft and spheroid experiments revealed that the CAIX expressors had increased viable tissue in HCT116 (A) xenografts (40% more viable tissue at day 14,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046b047b2dfb1cebd9a0eb2a4a3ce9fa
https://doi.org/10.1158/1078-0432.22443923.v1
https://doi.org/10.1158/1078-0432.22443923.v1
Autor:
Adrian L. Harris, Pawel Swietach, Richard D. Vaughan-Jones, William S. Sly, Kevin Gatter, Cameron Snell, Russell Leek, Helen Turley, Ioanna Ledaki, Ji-liang Li, Simon Wigfield, Shalini Patiar, Alan McIntyre
(244 KB) - Bar chart of scoring of immunohistochemistry and representative immunohistochemistry images of HT29 shCA9 and EV xenografts with and without Bevacizumab treatment. CAIX expression (**p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234dcc6a320157bc675025f7a876c7de
https://doi.org/10.1158/1078-0432.22443917
https://doi.org/10.1158/1078-0432.22443917
Autor:
Adrian L. Harris, Pawel Swietach, Richard D. Vaughan-Jones, William S. Sly, Kevin Gatter, Cameron Snell, Russell Leek, Helen Turley, Ioanna Ledaki, Ji-liang Li, Simon Wigfield, Shalini Patiar, Alan McIntyre
(8129 KB) - Bar chart of scoring of immunohistochemistry and representative immunohistochemistry images of HT29 xenografts with and without acetazolomide and/or Bevacizumab treatment. CAIX expression (vehicle (DMSO) *p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b78679de9bfe3d82a5e2e8daaa850b
https://doi.org/10.1158/1078-0432.22443914.v1
https://doi.org/10.1158/1078-0432.22443914.v1
Autor:
Adrian L. Harris, Pawel Swietach, Richard D. Vaughan-Jones, William S. Sly, Kevin Gatter, Cameron Snell, Russell Leek, Helen Turley, Ioanna Ledaki, Ji-liang Li, Simon Wigfield, Shalini Patiar, Alan McIntyre
(1056 KB) - Analysis of CA9 RNA expression in U87 xenografts untreated and with chronic Bevacizumab treatment. Bevacizumab treatement increased CA9 expression (***p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7449a2b7910b2df8a92e5174d66b2f
https://doi.org/10.1158/1078-0432.22443920.v1
https://doi.org/10.1158/1078-0432.22443920.v1
Autor:
Adrian L. Harris, Pawel Swietach, Angela Russell, Ji-Liang Li, Simon Wigfield, Esther Bridges, Dylan Jones, Peter Seden, Graham Steers, Dean Singleton, Cameron Snell, Ioanna Ledaki, Alzbeta Hulikova, Alan McIntyre
The expression of bicarbonate transporters in a panel of cell lines relative to the expression of β actin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03410bfa532a526847222f6f05bf2268
https://doi.org/10.1158/0008-5472.22407776.v1
https://doi.org/10.1158/0008-5472.22407776.v1
Autor:
Adrian L. Harris, Pawel Swietach, Angela Russell, Ji-Liang Li, Simon Wigfield, Esther Bridges, Dylan Jones, Peter Seden, Graham Steers, Dean Singleton, Cameron Snell, Ioanna Ledaki, Alzbeta Hulikova, Alan McIntyre
Validation of HIF1α and HIF2α knockdown by quantitative-PCR in Ls174T.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71aed5d69bb4a718a8968fbc10bd592
https://doi.org/10.1158/0008-5472.22407764.v1
https://doi.org/10.1158/0008-5472.22407764.v1
Autor:
Adrian L. Harris, Pawel Swietach, Angela Russell, Ji-Liang Li, Simon Wigfield, Esther Bridges, Dylan Jones, Peter Seden, Graham Steers, Dean Singleton, Cameron Snell, Ioanna Ledaki, Alzbeta Hulikova, Alan McIntyre
NDBT inhibition or knockdown increases the intracellular pH gradients, and doxycycline does not reduce the growth of U87 shCTL xenografts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136df8db497a09d60bced4b6b514aa3f
https://doi.org/10.1158/0008-5472.22407755.v1
https://doi.org/10.1158/0008-5472.22407755.v1
Autor:
Adrian L. Harris, Pawel Swietach, Angela Russell, Ji-Liang Li, Simon Wigfield, Esther Bridges, Dylan Jones, Peter Seden, Graham Steers, Dean Singleton, Cameron Snell, Ioanna Ledaki, Alzbeta Hulikova, Alan McIntyre
Hypoxic induction of bicarbonate transporters in U87 between 24 and 96 hours and in DLD-1 at 72 hours.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcfdce097e3880c971c36b7924ebe7a
https://doi.org/10.1158/0008-5472.22407770.v1
https://doi.org/10.1158/0008-5472.22407770.v1