Angiotensin‐converting‐enzyme insertion/deletion polymorphism, ACE activity, and COVID‐19: A rather controversial hypothesis. A case‐control study

Autor: A. Kominakis, Eftychia Polyzogopoulou, Georgios Antonakos, Christos Kroupis, Paraskevi Moutsatsou, Anastasia Antoniadou, Argirios E. Tsantes, Anna Papadopoulou, Sotirios Tsiodras, Vasiliki Papaevangelou, Apostolos Armaganidis, Ioanna Kokkinopoulou, Athina Nikolaidou, Eirini Maratou, Dimitra Dimopoulou, Paraskevi C. Fragkou

Publikováno v: Journal of Medical Virology

Accumulating data has shown a contribution of the renin‐angiotensin system in COVID‐19 pathogenesis. The role of angiotensin‐converting enzyme (ACE) insertion (I)/deletion (D) polymorphism as a risk factor in developing COVID‐19 disease comes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a474f9e4fb149d1310d5e009dcf3c9f
https://doi.org/10.1002/jmv.27417

Glucocorticoid Receptor Signaling in Diabetes

Autor: Paraskevi Moutsatsou, Andriana Diakoumi, Ioanna Kokkinopoulou

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11173, p 11173 (2021)
International Journal of Molecular Sciences

Stress and depression increase the risk of Type 2 Diabetes (T2D) development. Evidence demonstrates that the Glucocorticoid (GC) negative feedback is impaired (GC resistance) in T2D patients resulting in Hypothalamic-Pituitary-Adrenal (HPA) axis hype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46206865af84f9b122bb06ba4b4e326b
https://www.mdpi.com/1422-0067/22/20/11173

Blood-based analysis of type-2 diabetes mellitus susceptibility genes identifies specific transcript variants with deregulated expression and association with disease risk

Autor: Eirini Maratou, Efthimios Pappas, Ioanna Kokkinopoulou, Maria-Ioanna Christodoulou, Christos K. Kontos, Eleni Boutati, Emmanuel G. Fragoulis, Panayota Mitrou, Andreas Scorilas, Margaritis Avgeris

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports

Despite significant progress by genome-wide association studies, the ability of genetic variants to conduce to the prediction or prognosis of type-2 diabetes (T2D) is weak. Expression analysis of the corresponding genes may suggest possible links bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047fd7bf34da5cc16c1a507c8e98a1fb
http://link.springer.com/article/10.1038/s41598-018-37856-1

Mitochondrial Glucocorticoid Receptors and Their Actions

Autor: Ioanna Kokkinopoulou, Paraskevi Moutsatsou

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 6054, p 6054 (2021)
International Journal of Molecular Sciences

Mitochondria are membrane organelles present in almost all eukaryotic cells. In addition to their well-known role in energy production, mitochondria regulate central cellular processes, including calcium homeostasis, Reactive Oxygen Species (ROS) gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc66260ec5746b721500d66d47a6002
https://www.mdpi.com/1422-0067/22/11/6054

Comparative HPLC-DAD and UHPLC-ESI(-)-HRMS & MS/MS profiling of Hypericum species and correlation with necrotic cell-death activity in human leukemic cells

Autor: Job Tchoumtchoua, Ioanna Kokkinopoulou, Maria Halabalaki, Efstathia Papageorgiou, Nikolas Fokialakis, Andreas Scorilas, Maria-Ioanna Christodoulou, Maria-Eleni Sakavitsi, Leandros Skaltsounis, Aikaterini Argyropoulou

Publikováno v: Phytochemistry Letters. 20:481-490

In the search for potential new anti-cancer agents, the possible anti-proliferative effect of various plant extracts from an in-house extract library was investigated in vitro . The cytotoxic, cytostatic and the pro-apoptotic capacity of the extracts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e678529d58a42c87f0f2fec0dd61881d
https://doi.org/10.1016/j.phytol.2017.05.003