Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice

Autor: Patrick Tjok Joe, Ioanna Christopoulou, Lien van Hoecke, Bert Schepens, Tine Ysenbaert, Carlo Heirman, Kris Thielemans, Xavier Saelens, Joeri L. Aerts

Publikováno v: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-14 (2019)

Abstract Background Current human influenza vaccines lack the adaptability to match the mutational rate of the virus and therefore require annual revisions. Because of extensive manufacturing times and the possibility that antigenic alterations occur

Externí odkaz: https://doaj.org/article/c946bfff7a2147e0912ce56ac5b126eb

Broadened immunity against influenza by vaccination with computationally designed influenza virus N1 neuraminidase constructs

Autor: Tine Ysenbaert, Tod Strugnell, Harold Kleanthous, Thorsten U. Vogel, Raymond P. Oomen, Ioanna Christopoulou, Xavier Saelens, Emma R. Job, Anouk Smet, Eliud O. Oloo

Publikováno v: npj Vaccines, Vol 3, Iss 1, Pp 1-11 (2018)
NPJ Vaccines

Split inactivated influenza vaccines remain one of the primary preventative strategies against severe influenza disease in the population. However, current vaccines are only effective against a limited number of matched strains. The need for broadly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e194d28783785387f2bafe507c26808
http://link.springer.com/article/10.1038/s41541-018-0093-1

Neutralization of Junín virus by single domain antibodies targeted against the nucleoprotein

Autor: Paco Hulpiau, Xavier Saelens, Ioanna Christopoulou, Claudia Soledad Sepúlveda, Florencia N. Linero, Luis Alberto Scolaro

Publikováno v: Scientific Reports
SCIENTIFIC REPORTS
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The syndrome viral haemorrhagic fever (VHF) designates a broad range of diseases that are caused by different viruses including members of the family Arenaviridae. Prophylaxis for Argentine Haemorrhagic Fever (AHF), caused by the arenavirus Junín (J

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b74c19f6392e5a410d97007861f2b9
https://pubmed.ncbi.nlm.nih.gov/30061671

TIV Vaccination Modulates Host Responses to Influenza Virus Infection that Correlate with Protection against Bacterial Superinfection

Autor: Michael Schotsaert, Angela Choi, Ioanna Christopoulou, Adolfo García-Sastre, Xavier Saelens

Publikováno v: Vaccines
Volume 7
Issue 3
VACCINES
Vaccines, Vol 7, Iss 3, p 113 (2019)

Background: Influenza virus infection predisposes to secondary bacterial pneumonia. Currently licensed influenza vaccines aim at the induction of neutralizing antibodies and are less effective if the induction of neutralizing antibodies is low and/or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e589c9226916a3b330b3fa0d2a2c84d3
https://doi.org/10.3390/vaccines7030113

Influenza vaccines to control influenza-associated bacterial infection: Where do we stand?

Autor: Ioanna Christopoulou, Kenny Roose, Xavier Saelens, Lorena Itatí Ibañez

Influenza A virus is a pathogen that is feared for its capacity to cause pandemics. In this review, we illustrate the clinical evidence which support the theory that bacterial co-infection is a considerable risk factor for exacerbated disease during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02695995b212f58a131d4e880528b9b5
https://www.tandfonline.com/doi/abs/10.1586/14760584.2015.957191