Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ioana Puscalau-Girtu"'
Autor:
Thomas Heerde, Matthies Rennegarbe, Alexander Biedermann, Dilan Savran, Peter B. Pfeiffer, Manuel Hitzenberger, Julian Baur, Ioana Puscalau-Girtu, Martin Zacharias, Nadine Schwierz, Christian Haupt, Matthias Schmidt, Marcus Fändrich
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Here, the authors present the cryo-EM structure of in vitro amyloid fibrils from recombinant SAA1.1 protein that were formed by seeding with fibrils purified from systemic AA amyloidosis tissue. This in vitro fibril structure resembles the structure
Externí odkaz:
https://doaj.org/article/1dc8229b0dcb4b2fa12efbe783d6a181
Autor:
Akanksha Bansal, Matthias Schmidt, Matthies Rennegarbe, Christian Haupt, Falk Liberta, Sabrina Stecher, Ioana Puscalau-Girtu, Alexander Biedermann, Marcus Fändrich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Systemic AA amyloidosis is a protein misfolding disease caused by the formation of amyloid fibrils from serum amyloid A (SAA) protein. Here, the authors present the cryo-EM structures of AA amyloid fibrils isolated from mouse tissue and in vitro form
Externí odkaz:
https://doaj.org/article/15b5d0653a7f4fee9b6e4b37a7961e1e
Autor:
Silvio O. Rizzoli, Ioana Puscalau-Girtu, Stefan E. Szedlacsek, Aura E. Ionescu, Rodica A. Badea, Mihaela Mentel, Martin S. Helm
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-2 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Autor:
Aura E. Ionescu, Silvio O. Rizzoli, Mihaela Mentel, Stefan E. Szedlacsek, Martin S. Helm, Rodica A. Badea, Ioana Puscalau-Girtu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Eyes absent (EYA) proteins are unusual proteins combining in a single polypeptide chain transactivation, threonine phosphatase, and tyrosine phosphatase activities. They play pivotal roles in organogenesis and are involved in a variety of physiologic
Autor:
Marcus Fändrich, Julia Linder, Thomas Simmet, Katrin Meinhardt, Paul Walther, Tatiana Syrovets, Tobias Aumüller, Stephanie Claus, Ioana Puscalau-Girtu, Christian Haupt
Serum amyloid A1 (SAA1) is an apolipoprotein that binds to the high-density lipoprotein (HDL) fraction of the serum and constitutes the fibril precursor protein in systemic AA amyloidosis. We here show that HDL binding blocks fibril formation from so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d087b1fe1e114319d0a0ccea52991e
https://europepmc.org/articles/PMC5538634/
https://europepmc.org/articles/PMC5538634/
Autor:
Stephanie, Claus, Ioana, Puscalau-Girtu, Paul, Walther, Tatiana, Syrovets, Thomas, Simmet, Christian, Haupt, Marcus, Fändrich
Publikováno v:
Scientific Reports
Systemic AA amyloidosis arises from the misfolding of serum amyloid A1 (SAA1) protein and the deposition of AA amyloid fibrils at multiple sites within the body. Previous research already established that mononuclear phagocytes are crucial for the fo