Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Ioan TOMUTA"'
Autor:
Adriano P. Pontes, Steffen van der Wal, Saketh R. Ranamalla, Karin Roelofs, Ioan Tomuta, Laura B. Creemers, Jaap Rip
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Disulfide-containing poly(amidoamine) (PAA) is a cationic and bioreducible polymer, with potential use as a nanocarrier for mRNA delivery in the treatment of several diseases including osteoarthritis (OA). Successful transfection of joint cells with
Externí odkaz:
https://doaj.org/article/9754f335ed1c4961b19731fe693f481d
Autor:
Tryfon Digkas, Alina Porfire, Jeroen Van Renterghem, Aseel Samaro, Gheorghe Borodi, Chris Vervaet, Andrea Gabriela Crișan, Sonia Iurian, Thomas De Beer, Ioan Tomuta
Publikováno v:
Pharmaceuticals, Vol 16, Iss 8, p 1062 (2023)
The present study aimed to develop 3D printed dosage forms, using custom-made filaments loaded with diclofenac sodium (DS). The printed tablets were developed by implementing a quality by design (QbD) approach. Filaments with adequate FDM 3D printing
Externí odkaz:
https://doaj.org/article/79bf6d34b8734f32b2c23a73597116f7
Autor:
Dana MUNTEAN, Alina PORFIRE, Cristian ALECU, Sonia IURIAN, Tibor CASIAN, Alexandru GÂVAN, Ioan TOMUTA
Publikováno v:
Romanian Journal of Pharmaceutical Practice, Vol 14, Iss 2, Pp 68-75 (2021)
The use of near infrared (NIR) spectroscopy to predict the concentration of two active pharmaceutical ingredients (APIs), paracetamol and caffeine, in intact tablets, has been evaluated in this study. A partial least squares (PLS) regression model wa
Externí odkaz:
https://doaj.org/article/6d5b1461819147608ab77517aa0defd7
Publikováno v:
Romanian Journal of Pharmaceutical Practice, Vol 14, Iss 1, Pp 18-26 (2021)
The purpose of this research was to apply near-infrared (NIR) spectroscopy in combination with chemometrics to predict particle size and flow characteristics of a meloxicam powder blends for tableting. In order to develop calibration models for parti
Externí odkaz:
https://doaj.org/article/03f9ec120f6d4bba831cc54c2a1bbafb
Autor:
Elena Dinte, Rares Iuliu Iovanov, Andreea Elena Bodoki, Ioana Alina Colosi, Horatiu Alexandru Colosi, Nicoleta Tosa, Oliviu Vostinaru, Ioan Tomuta
Publikováno v:
Polymers, Vol 15, Iss 9, p 2023 (2023)
The aim of this study was to develop a suitable clotrimazole (CLT)-loaded mucoadhesive vaginal gel (CLT-MVG) for topical applications in vaginal candidiasis. Ten CLT-MVG formulations were prepared, consisting of mixtures of acid polyacrylic (Carbopol
Externí odkaz:
https://doaj.org/article/2b597124d1de444bbae7ede2d8e0ea02
Autor:
Alexandru Gavan, Sonia Iurian, Tibor Casian, Alina Porfire, Sebastian Porav, Ioana Voina, Alexandru Oprea, Ioan Tomuta
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 15, Iss 4, Pp 506-517 (2020)
The study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients, intended for coated tablets preparation and further transfer to industrial scale. The work aimed to prove that an accurate control of the
Externí odkaz:
https://doaj.org/article/6b7262d40e7d444cafafb843282cf330
Publikováno v:
Romanian Journal of Pharmaceutical Practice, Vol 13, Iss 2, Pp 66-78 (2020)
Objectives. The aim of this study was to optimize the formulation of certain immediate release foaming vaginal tablets, with fast vaginal disintegration (part I), fallowing their time stability (part II). Material and methods. Modde optimizing softw
Externí odkaz:
https://doaj.org/article/9f27b22f490e4657987976186333786f
Publikováno v:
Romanian Journal of Pharmaceutical Practice, Vol 13, Iss 2, Pp 57-65 (2020)
Objectives. The aim of this study was to develop and validate a NIR-chemometric method for direct quantification of loratadine in powder blends for tableting and tablets, without any sample preparation. Material and methods. Calibration samples were
Externí odkaz:
https://doaj.org/article/846036809aa7471d941b9c384ab103d1
Autor:
Cristina-Ioana Barbalata, Alina Silvia Porfire, Tibor Casian, Dana Muntean, Iulia Rus, Mihaela Tertis, Cecilia Cristea, Anca Pop, Julien Cherfan, Felicia Loghin, Ioan Tomuta
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1211 (2022)
The present study aimed to optimize a liposomal formulation co-encapsulating simvastatin (SIM) and doxorubicin (DOX) that has future perspectives in anticancer therapy. The optimization process was performed by implementing the Quality by Design conc
Externí odkaz:
https://doaj.org/article/ca9d049830a24ad6997cd6f87702059a
Autor:
Anca Pop, Ionel Fizeșan, Laurian Vlase, Marius Emil Rusu, Julien Cherfan, Mihai Babota, Ana-Maria Gheldiu, Ioan Tomuta, Daniela-Saveta Popa
Publikováno v:
Antioxidants, Vol 10, Iss 4, p 607 (2021)
The extraction of bioactive compounds present in walnut (Juglans regia L.) male flowers (WMFs) was performed based on an experimental design using ultrasonic-assisted extraction. Solvent nature, extraction time, and water content were selected as exp
Externí odkaz:
https://doaj.org/article/ba921b82549c42e3b5ce13fefec0a0d0