Výsledky vyhledávání - "Inwardly Rectifying/metabolism"

Upregulation of an inward rectifying K+channel can rescue slow Ca2+oscillations in K(ATP) channel deficient pancreatic islets

Autor: Benjamin Thompson, Suryakiran Vadrevu, Vehpi Yildirim, Leslie S. Satin, Richard Bertram

Publikováno v: PLoS Computational Biology, 13(7):e1005686. Public Library of Science
PLoS computational biology, 13(7):e1005686. Public Library of Science
PLoS Computational Biology, Vol 13, Iss 7, p e1005686 (2017)
PLoS Computational Biology

Plasma insulin oscillations are known to have physiological importance in the regulation of blood glucose. In insulin-secreting β-cells of pancreatic islets, K(ATP) channels play a key role in regulating glucose-dependent insulin secretion. In addit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a624b8e625a66c2a69a3a8fea4a14110
https://research.tue.nl/nl/publications/ad9de0ac-c696-4cbd-bc67-3292ccb60910

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Severe hyperkalemia is rescued by low-potassium diet in renal βENaC-deficient mice

Autor: Emilie Boscardin, Johannes Loffing, Dominique Loffing-Cueni, Edith Hummler, Bernard C. Rossier, Chloé Sergi, Romain Perrier, Marc Maillard, Robert Koesters

Publikováno v: Pflugers Archiv, vol. 469, no. 10, pp. 1387-1399

In adulthood, an induced nephron-specific deficiency of αENaC (Scnn1a) resulted in pseudohypoaldosteronism type 1 (PHA-1) with sodium loss, hyperkalemia, and metabolic acidosis that is rescued through high-sodium/low-potassium (HNa + /LK + ) diet. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a1ef2196951d1c6364d79f30b935ba
https://www.zora.uzh.ch/id/eprint/138075/

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Membrane Hyperpolarization Triggers Myogenin and Myocyte Enhancer Factor-2 Expression during Human Myoblast Differentiation

Autor: Stéphane König, Laurent Bernheim, Serge Arnaudeau, Nicolas Holzer, Charles R. Bader, Gael Potter, Valérie Hinard

Publikováno v: Journal of Biological Chemistry, Vol. 279, No 27 (2004) pp. 28187-28196

It is widely thought that myogenin is one of the earliest detectable markers of skeletal muscle differentiation. Here we show that, during human myoblast differentiation, an inward rectifier K(+) channel (Kir2.1) and its associated hyperpolarization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153e759543f0ed9d0f98a05e938bb861
https://doi.org/10.1074/jbc.m313932200

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Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension

Autor: Caroline Ronzaud, Natasha A. Boase, Johannes Loffing, Baoli Yang, Romain Perrier, Nicole Fowler-Jaeger, Edith Hummler, Dominique Loffing-Cueni, Sumedha Malsure, Marc Maillard, Sharad Kumar, Pierrette Hausel, Olivier Staub, Robert Koesters, Anne Debonneville, John B. Stokes

Publikováno v: JOURNAL OF CLINICAL INVESTIGATION
The Journal of clinical investigation
Journal of Clinical Investigation, vol. 123, no. 2, pp. 657-665

The E3 ubiquitin ligase NEDD4-2 (encoded by the Nedd4L gene) regulates the amiloride-sensitive epithelial Na+ channel (ENaC/SCNN1) to mediate Na+ homeostasis. Mutations in the human β/γENaC subunits that block NEDD4-2 binding or constitutive ablati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6aca30dd9502628d1136dbf02e2ac2
https://hdl.handle.net/1959.8/155486

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Increased expression of adenosine triphosphate-sensitive K+ channels in mitral dysfunction: mechanically stimulated transcription and hypoxia-induced protein stability?

Autor: Raeis Dauvé, V., Philip Couderc, P., Faggian, Giuseppe, Tessari, Maddalena, Roatti, A., Milano, Aldo Domenico, Bochaton Piallat, M., Baertschi, A. J.

Publikováno v: Journal of the American College of Cardiology, Vol. 59, No 4 (2012) pp. 390-6
Journal of the American College of Cardiology

OBJECTIVES The aim of this study was to test whether adenosine triphosphate sensitive K(+) (KATP) channel expression relates to mechanical and hypoxic stress within the left human heart. BACKGROUND The KATP channels play a vital role in preserving th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::986ce008d4f9f79046d24a645bcc9f2c
https://archive-ouverte.unige.ch/unige:26258

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Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach

Autor: Marisa Jaconi, Elisabetta Cerbai, Laura Sartiani, Francesca Stillitano, Alessandro Mugelli, Esther Bettiol

Publikováno v: Stem Cells, Vol. 25, No 5 (2007) pp. 1136-1144

Cardiomyocytes derived from human embryonic stem cells constitute a promising cell source for the regeneration of damaged hearts. The assessment of their in vitro functional properties is mandatory to envisage appropriate cardiac cell-based therapies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90129402354f8d1251e7ed649b8928a2
https://pubmed.ncbi.nlm.nih.gov/17255522

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Inhibition of constitutive inward rectifier currents in cerebellar granule cells by pharmacological and synaptic activation of GABA receptors

Autor: Paola Rossi, David Gall, Alban de Kerchove d'Exaerde, Vanni Taglietti, Lisa Mapelli, Leda Roggeri, Serge N. Schiffmann, Egidio D'Angelo

Publikováno v: European journal of neuroscience, 24 (2

gamma-Aminobutyric acid (GABA)(B) receptors are known to enhance activation of Kir3 channels generating G-protein-dependent inward rectifier K(+)-currents (GIRK). In some neurons, GABA(B) receptors either cause a tonic GIRK activation or generate a l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21358fb9018ec1452fbb29bd88a21fe
https://pubmed.ncbi.nlm.nih.gov/16903850

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The calcineurin pathway links hyperpolarization (Kir2.1)-induced Ca2+ signals to human myoblast differentiation and fusion

Autor: Charles R. Bader, Anne Béguet, Laurent Bernheim, Stéphane König

Publikováno v: Development, Vol. 133, No 16 (2006) pp. 3107-3114

In human myoblasts triggered to differentiate, a hyperpolarization,resulting from K+ channel (Kir2.1) activation, allows the generation of an intracellular Ca2+ signal. This signal induces an increase in expression/activity of two key transcription f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845cf40917dfd826823e7e30c0dd86af
https://pubmed.ncbi.nlm.nih.gov/16831831

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The antiarrhythmic effect and clinical consequences of ischemic preconditioning

Autor: Evrengul H, Seleci D, Tanriverdi H, Kaftan A

Potentially hazardous short ischemic episodes increase the tolerance of myocardium to ischemia paradoxically. This condition decreases the infarct area markedly caused by a longer duration of coronary occlusion. This phenomenon is known as 'ischemic

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