Zobrazeno 1 - 10
of 1 195
pro vyhledávání: '"Intrinsic resistance"'
Autor:
Mariam M. Konaté, Julia Krushkal, Ming-Chung Li, Li Chen, Yuri Kotliarov, Alida Palmisano, Rini Pauly, Qian Xie, P. Mickey Williams, Lisa M. McShane, Yingdong Zhao
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background With poor prognosis and high mortality, pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Standard of care therapies for PDAC have included gemcitabine for the past three decades, although resistance
Externí odkaz:
https://doaj.org/article/8450290fb1bd45a187afecbd4534732f
Autor:
Hayato Koba, Taro Yoneda, Hiroko Morita, Hideharu Kimura, Yuya Murase, Nanao Terada, Yuichi Tambo, Masafumi Horie, Kazuo Kasahara, Isao Matsumoto, Seiji Yano
Publikováno v:
Thoracic Cancer, Vol 15, Iss 8, Pp 661-666 (2024)
Abstract Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) is crucial for patients with lung cancer harboring EGFR mutations. However, almost all patients experience disease progression, regardless of their response to the targe
Externí odkaz:
https://doaj.org/article/af7ce787e5bc4d3ebe70309ad5c2ea41
Autor:
Elham Omer Mahgoub, William C. Cho, Majid Sharifi, Mojtaba Falahati, Hojjat Alizadeh Zeinabad, Hany E. Mare, Anwarul Hasan
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e22095- (2024)
Functional genomics is an emerging field focused on elucidating the functions of genes or proteins, which can help solve challenges related to reliable cancer therapy. One of the main challenges currently faced by cancer therapy is the variations in
Externí odkaz:
https://doaj.org/article/b0ae6b4ef5cd4f0690fad0632ccb55fb
Autor:
Shuai Wang, Jingran Zhang, H. M. Adnan Hameed, Jie Ding, Ping Guan, Xiange Fang, Jiacong Peng, Biyi Su, Shangming Ma, Yaoju Tan, Gregory M. Cook, Guoliang Zhang, Yongping Lin, Nanshan Zhong, Jinxing Hu, Jianxiong Liu, Tianyu Zhang
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT The polymorphism at amino acid 17 of quinolone resistance-determining region of GyrA has been stated with a potential role in fluoroquinolone susceptibility in different mycobacterial species. However, no study has provided dependable eviden
Externí odkaz:
https://doaj.org/article/053a7632f01a4e70874f3ec6d35e8586
Publikováno v:
Journal of Water and Health, Vol 21, Iss 5, Pp 560-570 (2023)
Metallo-β-lactamases (MBLs) encoding carbapenem resistance in wastewater are a well-known serious threat to human health. Twelve Pseudomonas otitidis isolates obtained from a municipal wastewater treatment plant (WWTP) in Hawaii were found to posses
Externí odkaz:
https://doaj.org/article/04bb85898e114de38c749ac975a53b89
Autor:
Yueqin Wang, Jingyao Wei, Luyao Feng, Ouwen Li, Lan Huang, Shaoxuan Zhou, Yingjie Xu, Ke An, Yu Zhang, Ruiying Chen, Lulu He, Qiming Wang, Han Wang, Yue Du, Ruijuan Liu, Chunmin Huang, Xiaojian Zhang, Yun-gui Yang, Quancheng Kan, Xin Tian
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-18 (2023)
Abstract Background RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear. Methods The correla
Externí odkaz:
https://doaj.org/article/8909af3ec9fb4407ac02389074086cb1
Autor:
EFSA Panel on Biological Hazards (BIOHAZ), Konstantinos Koutsoumanis, Ana Allende, Avelino Alvarez‐Ordóñez, Declan Bolton, Sara Bover‐Cid, Marianne Chemaly, Alessandra De Cesare, Friederike Hilbert, Roland Lindqvist, Maarten Nauta, Romolo Nonno, Luisa Peixe, Giuseppe Ru, Marion Simmons, Panagiotis Skandamis, Elisabetta Suffredini, Pier Sandro Cocconcelli, Juan Evaristo Suarez, Estefania Noriega Fernández, Frédérique Istace, Jaime Aguillera, Rosella Brozzi, Ernesto Liébana, Beatriz Guerra, Sandra Correia, Lieve Herman
Publikováno v:
EFSA Journal, Vol 21, Iss 10, Pp n/a-n/a (2023)
Abstract The qualified presumption of safety (QPS) approach was developed to provide a regularly updated generic pre‐evaluation of the safety of microorganisms intended for use in the food or feed chains. Safety concerns identified for a taxonomic
Externí odkaz:
https://doaj.org/article/1a74eed718974325bfc0ffd7595a466f
Autor:
Rodolfo Chavez-Dominguez, Dolores Aguilar-Cazares, Mario Perez-Medina, Santiago Avila-Rios, Maribel Soto-Nava, Alfonso Mendez-Tenorio, Lorenzo Islas-Vazquez, Jesus J. Benito-Lopez, Miriam Galicia-Velasco, Jose S. Lopez-Gonzalez
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Resistance to cisplatin is the main cause of treatment failure in lung adenocarcinoma. Drug-tolerant-persister (DTP) cells are responsible for intrinsic resistance, since they survive the initial cycles of treatment, representing a reservoir for the
Externí odkaz:
https://doaj.org/article/3b7a6ea36b2f4d6ea9f7348e6cdfd619
Autor:
Katrine Nøhr-Meldgaard, Carsten Struve, Hanne Ingmer, Anna Koza, Kosai Al-Nakeeb, Yvonne Agersø
Publikováno v:
Frontiers in Antibiotics, Vol 2 (2023)
IntroductionIn this work, 170 strains covering 13 species from the Lactobacillaceae family were analyzed to determine minimal inhibitory concentration (MIC) distributions to nine antimicrobial agents, and genes potentially conferring resistance. This
Externí odkaz:
https://doaj.org/article/828c1c3cf49c416dab08194db28ed969
Autor:
Karen Gambaro, Maud Marques, Suzan McNamara, Mathilde Couetoux du Tertre, Cyrla Hoffert, Archana Srivastava, Anna Schab, Thierry Alcindor, Adrian Langleben, Lucas Sideris, Mahmoud Abdelsalam, Mustapha Tehfe, Felix Couture, Gerald Batist, Petr Kavan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 43 (2023)
Single-agent regorafenib is approved in Canada for metastatic colorectal cancer (mCRC) patients who have failed previous lines of therapy. Identifying prognostic biomarkers is key to optimizing therapeutic strategies for these patients. In this clini
Externí odkaz:
https://doaj.org/article/ec86c695c34645c382ed30a6f5995a36