Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Intrathecal delivery"'
Autor:
Svenja Meissner, Salvador Lopez, Shaun Rees, Simon O’Carroll, David Barker, Bruce Harland, Brad Raos, Darren Svirskis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Neurotrophic growth factor (GF) loaded hydrogels have shown promise as a treatment approach for spinal cord injury (SCI). However, SCI presents complex challenges for the direct administration of treatment due to the spinal cord’s intricat
Externí odkaz:
https://doaj.org/article/a57810a9f4af4b8683cb0276e2670b05
Autor:
Luz Estella Mesa Bedoya, Jhyld Carolaind Camacho Barbosa, Lucas López Quiceno, Freddy Barrios Arroyave, Karolynn Halpert, Julián Andrés España Peña, Juan Carlos Salazar Uribe
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Background Based on previous in vivo studies and human trials, intrathecal cell delivery is a safe and relevant therapeutic tool for improving patient's quality of life with neurological conditions. We aimed to characterise the safety profil
Externí odkaz:
https://doaj.org/article/fe11cb5f8cd04aa9bdf25d476bf90cc5
Autor:
Qing Li, Yan-ling Long, Yun-wu He, Hui Long, Zhen-ping Xiao, Yong-lin Li, Wu-zhou Yang, Li-ping Jiang, Wei Gao, Cong Zou
Publikováno v:
BMC Anesthesiology, Vol 24, Iss 1, Pp 1-5 (2024)
Abstract Background Extensive metastatic and refractory cancer pain is common, and exhibits a dissatisfactory response to the conventional intrathecal infusion of opioid analgesics. Case Presentation The present study reports a case of an extensive m
Externí odkaz:
https://doaj.org/article/42e0aa43134d48be9aafc73175dd74c4
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 2, Pp 456-462 (2023)
Previous studies have confirmed the relationship between iron-dependent ferroptosis and a peripheral nerve injury-induced neuropathic pain model. However, the role of ferroptosis in inflammatory pain remains inconclusive. Therefore, we aimed to explo
Externí odkaz:
https://doaj.org/article/3c59320f21a74210bf3cf44a8d23ed3d
Akademický článek
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Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Intrathecal administration is an important mode for delivering biological agents targeting central nervous system (CNS) diseases. However, current clinical practices lack a sound theorical basis for a quantitative understanding of the variables and c
Externí odkaz:
https://doaj.org/article/d25f6201d50e47008f361742b540def5
Autor:
Karim Bey, Johan Deniaud, Laurence Dubreil, Béatrice Joussemet, Joseph Cristini, Carine Ciron, Juliette Hordeaux, Morwenn Le Boulc’h, Kevin Marche, Maud Maquigneau, Michaël Guilbaud, Rosalie Moreau, Thibaut Larcher, Jack-Yves Deschamps, Marion Fusellier, Véronique Blouin, Caroline Sevin, Nathalie Cartier, Oumeya Adjali, Patrick Aubourg, Philippe Moullier, Marie-Anne Colle
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 771-784 (2020)
The identification of the most efficient method for whole central nervous system targeting that is translatable to humans and the safest route of adeno-associated virus (AAV) administration is a major concern for future applications in clinics. Addit
Externí odkaz:
https://doaj.org/article/a0aedb1aca064422b991e72f09f1cc8d
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1738 (2022)
Immunotherapy has revolutionized cancer treatment. Despite the recent advances in immunotherapeutic approaches for several tumor entities, limited response has been observed in malignant gliomas, including glioblastoma (GBM). Conversely, one of the e
Externí odkaz:
https://doaj.org/article/45bb697b7ed54e13a2b9b8a6876044af