Zobrazeno 1 - 10 of 63 pro vyhledávání: '"Intranasal treatment"'
1
Akademický článek
SARS-CoV-2 Specific Nanobodies Neutralize Different Variants of Concern and Reduce Virus Load in the Brain of h-ACE2 Transgenic Mice
Autor: María Florencia Pavan, Marina Bok, Rafael Betanzos San Juan, Juan Pablo Malito, Gisela Ariana Marcoppido, Diego Rafael Franco, Daniela Ayelen Militelo, Juan Manuel Schammas, Sara Elizabeth Bari, William Stone, Krisangel López, Danielle LaBrie Porier, John Anthony Muller, Albert Jonathan Auguste, Lijuan Yuan, Andrés Wigdorovitz, Viviana Gladys Parreño, Lorena Itat Ibañez
Publikováno v: Viruses, Vol 16, Iss 2, p 185 (2024)
Since the beginning of the COVID-19 pandemic, there has been a significant need to develop antivirals and vaccines to combat the disease. In this work, we developed llama-derived nanobodies (Nbs) directed against the receptor binding domain (RBD) and
Externí odkaz: https://doaj.org/article/5eba587ec99b43638a5876bf15935f93
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2
Akademický článek
Novel Targets and Interventions for Cognitive Complications of Diabetes
Autor: Victoria Wolf, Yasir Abdul, Adviye Ergul
Publikováno v: Frontiers in Physiology, Vol 12 (2022)
Diabetes and cognitive dysfunction, ranging from mild cognitive impairment to dementia, often coexist in individuals over 65 years of age. Vascular contributions to cognitive impairment/dementia (VCID) are the second leading cause of dementias under
Externí odkaz: https://doaj.org/article/1a07c18e495342f4b3aeb6335c8bca0c
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3
Akademický článek
Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer’s Disease
Autor: Oksana Fihurka, Yanhong Wang, Yuzhu Hong, Xiaoyang Lin, Ning Shen, Haiqiang Yang, Breanna Brown, Marcus Mommer, Tarek Zieneldien, Yitong Li, Janice Kim, Minghua Li, Jianfeng Cai, Qingyu Zhou, Chuanhai Cao
Publikováno v: Biomolecules, Vol 13, Iss 2, p 232 (2023)
Melatonin, insulin, and Δ9-tetrahydrocannabinol (THC) have been shown to reverse cognitive deficits and attenuate neuropathologies in transgenic mouse models of Alzheimer’s disease (AD) when used individually. Here, we evaluated the therapeutic pr
Externí odkaz: https://doaj.org/article/4405b4704d5948578a4dd975890cb8c7
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4
Akademický článek
Intranasal HSP70 administration protects against dopaminergic denervation and modulates neuroinflammatory response in the 6-OHDA rat model
Autor: Camila Tiefensee Ribeiro, Daniel Oppermann Peixoto, Lucas Santos, Carolina Saibro-Girardi, Pedro Ozorio Brum, Flávio Gabriel Carazza-Kessler, Nauana Somensi, Luiza Marques Prates Behrens, Reykla Ramon Bittencourt, Laíssa Santos Soares, Alexandre Kleber Silveira, Jade de Oliveira, José Cláudio Fonseca Moreira, Juciano Gasparotto, Daniel Pens Gelain
Publikováno v: Brain, Behavior, & Immunity - Health, Vol 14, Iss , Pp 100253- (2021)
HSP70 is one of the main molecular chaperones involved in the cellular stress response. Besides its chaperone action, HSP70 also modulates the immune response. Increased susceptibility to toxic insults in intra- and extracellular environments has bee
Externí odkaz: https://doaj.org/article/3fbb91b0789d4d929b2039c8f432b21c
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5
Akademický článek
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6
Akademický článek
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7
Akademický článek
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8
Functional Recovery Caused by Human Adipose Tissue Mesenchymal Stem Cell-Derived Extracellular Vesicles Administered 24 h after Stroke in Rats
Autor: Luis Pedro Bernardi, Fátima Theresinha Costa Rodrigues Guma, Luciele Varaschini Teixeira, Fernanda dos Santos de Oliveira, Elizabeth Obino Cirne Lima, Geciele Rodrigues Teixeira, Francieli Rohden, Pamela C.L. Ferreira, Mariana Colombo, Diogo O. Souza
Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12860
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
International Journal of Molecular Sciences, Vol 22, Iss 12860, p 12860 (2021)
International Journal of Molecular Sciences
Ischemic stroke is a major cause of death and disability, intensely demanding innovative and accessible therapeutic strategies. Approaches presenting a prolonged period for therapeutic intervention and new treatment administration routes are promisin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48dfb1a4def4074dddc9c534aea6951
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9
Akademický článek
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10
Intranasal HSP70 administration protects against dopaminergic denervation and modulates neuroinflammatory response in the 6-OHDA rat model
Autor: Carolina Saibro-Girardi, Luiza Marques Prates Behrens, Alexandre Kleber Silveira, Reykla Ramon Bittencourt, Lucas A. S. Santos, Jade de Oliveira, Juciano Gasparotto, Pedro Ozorio Brum, Daniel Pens Gelain, Nauana Somensi, Daniel Oppermann Peixoto, José Cláudio Fonseca Moreira, Flávio Gabriel Carazza-Kessler, Laíssa Santos Soares, Camila Tiefensee Ribeiro
Publikováno v: Brain, Behavior, & Immunity-Health, Vol 14, Iss, Pp 100253-(2021)
Brain, Behavior, & Immunity-Health
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
HSP70 is one of the main molecular chaperones involved in the cellular stress response. Besides its chaperone action, HSP70 also modulates the immune response. Increased susceptibility to toxic insults in intra- and extracellular environments has bee
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80f58faaaa64940f729395bc20cfe2d
http://www.sciencedirect.com/science/article/pii/S2666354621000569
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