Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Intracellular Signaling Peptides and Proteins/metabolism"'
Autor:
Ali Seifinejad, Mergim Ramosaj, Ling Shan, Sha Li, Marie-Laure Possovre, Corinne Pfister, Rolf Fronczek, Lee A. Garrett-Sinha, David Frieser, Makoto Honda, Yoan Arribat, Dogan Grepper, Francesca Amati, Marie Picot, Andrea Agnoletto, Christian Iseli, Nicolas Chartrel, Roland Liblau, Gert J. Lammers, Anne Vassalli, Mehdi Tafti
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 120(19). National Academy of Sciences
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune destruction of hypocretin-producing neurons. HCRT deficiency can also occur i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f97057d7c799183cb3bcbacf97011bf
https://doi.org/10.1073/pnas.2220911120
https://doi.org/10.1073/pnas.2220911120
Autor:
Esther Stroo, Leen Janssen, Olga Sin, Wytse Hogewerf, Mirjam Koster, Liesbeth Harkema, Sameh A Youssef, Natalie Beschorner, Anouk HG Wolters, Bjorn Bakker, Lore Becker, Lilian Garrett, Susan Marschall, Sabine M Hoelter, Wolfgang Wurst, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Amantha Thathiah, Floris Foijer, Bart van de Sluis, Jan van Deursen, Matthias Jucker, Alain de Bruin, Ellen AA Nollen
Publikováno v:
Life science alliance 6(7), e202201730 (2023). doi:10.26508/lsa.202201730
In age-related neurodegenerative diseases, like Alzheimer’s and Parkinson’s, disease-specific proteins become aggregation-prone and form amyloid-like deposits. Depletion of SERF proteins ameliorates this toxic process in worm and human cell model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2dc28445569fccfa99cc8b093ea779
https://pub.dzne.de/record/257883
https://pub.dzne.de/record/257883
Autor:
Daan Dierickx, Philippe Gaulard, Carlos Graux, Koen Debackere, Laurence de Leval, Nicole Mentens, Jan Cools, Lucienne Michaux, Kris Jacobs, Thomas Tousseyn, Sofie Demeyer, Olga Gielen, Michaël Broux, Iwona Wlodarska, Marlies Vanden Bempt, Lukas Marcelis, Gregor Verhoef
Publikováno v:
Nature communications, vol. 12, no. 1, pp. 3705
Nature communications, Vol. 12, no.1, p. 3705 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature communications, Vol. 12, no.1, p. 3705 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor prognosis. Up to 30% of PTCL lack distinctive features and are classified as PTCL, not otherwise specified (PTCL-NOS). To further improve our understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133ce4ef8eab96b32fc1be9ac3896731
https://doi.org/10.1038/s41467-021-24037-4
https://doi.org/10.1038/s41467-021-24037-4
Autor:
Martin J. Humphries, Paul N. Bishop, Nadhim Bayatti, Maja Søberg Udsen, Rawshan Choudhury, Viranga Tilakaratna, Selina McHarg, Richard Scharff, Ewa Szula, Simon J. Clark, Janet A. Askari
Publikováno v:
Scientific Reports
Choudhury, R, Bayatti, N, Scharff, R, Szula, E, Tilakaratna, V, Udsen, M, Mcharg, S, Askari, J, Humphries, M J, Bishop, P & Clark, S 2021, ' FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress ', Scientific Reports, vol. 11, no. 1, 14175 . https://doi.org/10.1038/s41598-021-93708-5
Choudhury, R, Bayatti, N, Scharff, R, Szula, E, Tilakaratna, V, Udsen, M S, McHarg, S, Askari, J A, Humphries, M J, Bishop, P N & Clark, S J 2021, ' FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress ', Scientific Reports, vol. 11, 14175 . https://doi.org/10.1038/s41598-021-93708-5
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Choudhury, R, Bayatti, N, Scharff, R, Szula, E, Tilakaratna, V, Udsen, M, Mcharg, S, Askari, J, Humphries, M J, Bishop, P & Clark, S 2021, ' FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress ', Scientific Reports, vol. 11, no. 1, 14175 . https://doi.org/10.1038/s41598-021-93708-5
Choudhury, R, Bayatti, N, Scharff, R, Szula, E, Tilakaratna, V, Udsen, M S, McHarg, S, Askari, J A, Humphries, M J, Bishop, P N & Clark, S J 2021, ' FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress ', Scientific Reports, vol. 11, 14175 . https://doi.org/10.1038/s41598-021-93708-5
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Retinal pigment epithelial (RPE) cells that underlie the neurosensory retina are essential for the maintenance of photoreceptor cells and hence vision. Interactions between the RPE and their basement membrane, i.e. the inner layer of Bruch’s membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd44c6c515f5cf3e410767874f2acb8
https://pubmed.ncbi.nlm.nih.gov/34239032
https://pubmed.ncbi.nlm.nih.gov/34239032
Autor:
Giuseppina Milano, Michele Samaja
Publikováno v:
International Journal of Molecular Sciences
International journal of molecular sciences, vol. 21, no. 4, pp. 1527
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1527 (2020)
International journal of molecular sciences, vol. 21, no. 4, pp. 1527
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1527 (2020)
“The Chimera was, according to Greek mythology, a monstrous fire-breathing hybrid creature of Lycia in Asia Minor, composed of the parts of more than one animal [...]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9c0d386aa89d4edd02e95e1c8a9d2a
https://pubmed.ncbi.nlm.nih.gov/32102292
https://pubmed.ncbi.nlm.nih.gov/32102292
Autor:
Fan He, Eiko K. de Jong, Laura Lorés-Motta, John R.W. Yates, Sascha Fauser, Anthony T. Moore, B. Paul Morgan, Nadhim Bayatti, Selina McHarg, Ilhan Erkin Acar, Simon J. Clark, Anneke I. den Hollander, Carel B. Hoyng, Paul N. Bishop, Valentina Cipriani, Dina Fathalla, Viranga Tilakaratna
Publikováno v:
Nature Communications
Nature Communications, 11
Cipriani, V, Lores-Motta, L, He, F, Fathalla, D, Tilakaratna, V, Mcharg, S, Bayatti, N, Acar, I E, Hyong, C B, Fauser, S, Moore, A T, Yates, J R W, de Jong, E K, Morgan, B P, den Hollander, A I, Bishop, P & Clark, S 2020, ' Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration ', Nature Communications, vol. 11, no. 1, 778, pp. 778 . https://doi.org/10.1038/s41467-020-14499-3
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11, 1
Nature Communications, 11
Cipriani, V, Lores-Motta, L, He, F, Fathalla, D, Tilakaratna, V, Mcharg, S, Bayatti, N, Acar, I E, Hyong, C B, Fauser, S, Moore, A T, Yates, J R W, de Jong, E K, Morgan, B P, den Hollander, A I, Bishop, P & Clark, S 2020, ' Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration ', Nature Communications, vol. 11, no. 1, 778, pp. 778 . https://doi.org/10.1038/s41467-020-14499-3
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11, 1
Age-related macular degeneration (AMD) is a leading cause of blindness. Genetic variants at the chromosome 1q31.3 encompassing the complement factor H (CFH, FH) and CFH related genes (CFHR1-5) are major determinants of AMD susceptibility, but their m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cc8d9a95cdbfac23be641800dac97a
http://europepmc.org/articles/PMC7005798
http://europepmc.org/articles/PMC7005798
Autor:
Normand, Sylvain, Waldschmitt, Nadine, Neerincx, Andreas, Martinez-Torres, Ruben Julio, Chauvin, Camille, Couturier-Maillard, Aurelie, Boulard, Olivier, Cobret, Laetitia, Awad, Fawaz, Huot, Ludovic, Ribeiro-Ribeiro, Andre, Lautz, Katja, Ruez, Richard, Delacre, Myriam, Bondu, Clovis, Guilliams, Martin, Scott, Charlotte, Segal, Anthony, Amselem, Serge, Hot, David, Karabina, Sonia, Bohn, Erwin, Ryffel, Bernhard, Poulin, Lionel F, Kufer, Thomas A, Chamaillard, Mathias
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications, 2018, 9, pp.5338. ⟨10.1038/s41467-018-07750-5⟩
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-07750-5⟩
Nature Communications, Nature Publishing Group, 2018, 9, pp.5338. ⟨10.1038/s41467-018-07750-5⟩
NATURE COMMUNICATIONS
Nature Communications
Nature Communications, 2018, 9, pp.5338. ⟨10.1038/s41467-018-07750-5⟩
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-07750-5⟩
Nature Communications, Nature Publishing Group, 2018, 9, pp.5338. ⟨10.1038/s41467-018-07750-5⟩
NATURE COMMUNICATIONS
Mutations in the nucleotide-binding oligomerization domain protein 12 (NLRP12) cause recurrent episodes of serosal inflammation. Here we show that NLRP12 efficiently sequesters HSP90 and promotes K48-linked ubiquitination and degradation of NOD2 in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e50944fc482415c00f8748ca8a1bb1ad
http://link.springer.com/article/10.1038/s41467-018-07750-5
http://link.springer.com/article/10.1038/s41467-018-07750-5
A phosphorylation switch turns a positive regulator of phototropism into an inhibitor of the process
Autor:
Paolo Schumacher, Emilie Demarsy, Patrice Waridel, Laure Allenbach Petrolati, Martine Trevisan, Christian Fankhauser
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature communications, vol. 9, no. 1, pp. 2403
Nature communications, vol. 9, no. 1, pp. 2403
Phototropins are light-activated protein kinases, which contribute to photosynthesis optimization both through enhancement of photon absorption when light is limiting and avoidance responses in high light. This duality is in part endowed by the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dd308fb048588ff1769560312bf8c04a
https://doaj.org/article/3361a00a7d2e48cead58f940111be7fa
https://doaj.org/article/3361a00a7d2e48cead58f940111be7fa
Publikováno v:
Physiological Reviews, Vol. 99, No 4 (2019) pp. 1655-1699
Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in intracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1400::e1e00bb7d20f8c9f9460369e4b16ae73
https://archive-ouverte.unige.ch/unige:127269
https://archive-ouverte.unige.ch/unige:127269
Autor:
Christopher J. Farady, Benjamin Demarco, Kaiwen W. Chen, Andreas Boettcher, Petr Broz, Kateryna Shkarina, Rosalie Heilig, Pawel Pelczar
Publikováno v:
The EMBO Journal
EMBO J
The EMBO journal, vol. 38, no. 10
EMBO J
The EMBO journal, vol. 38, no. 10
Pyroptosis is a form of lytic inflammatory cell death driven by inflammatory caspase-1, caspase-4, caspase-5 and caspase-11. These caspases cleave and activate the pore-forming protein gasdermin D (GSDMD) to induce membrane damage. By contrast, apopt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39750083470679bfc67d24cc783b03b0