Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Intra-tumour heterogeneity"'
Autor:
Srinivasa Rao, Clare Verrill, Lucia Cerundolo, Nasullah Khalid Alham, Zeynep Kaya, Miriam O’Hanlon, Alicia Hayes, Adam Lambert, Martha James, Iain D. C. Tullis, Jane Niederer, Shelagh Lovell, Altan Omer, Francisco Lopez, Tom Leslie, Francesca Buffa, Richard J. Bryant, Alastair D. Lamb, Boris Vojnovic, David C. Wedge, Ian G. Mills, Dan J. Woodcock, Ian Tomlinson, Freddie C. Hamdy
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background Extension of prostate cancer beyond the primary site by local invasion or nodal metastasis is associated with poor prognosis. Despite significant research on tumour evolution in prostate cancer metastasis, the emergence and evolut
Externí odkaz:
https://doaj.org/article/fea0ecc091594c4e9bf661d9a47540cf
Publikováno v:
BMC Ecology and Evolution, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Background Despite intensive research, cancer remains a major health problem. The difficulties in treating cancer reflect the complex nature of this disease, including high levels of heterogeneity within tumours. Intra-tumour heterogeneity c
Externí odkaz:
https://doaj.org/article/0ffca5856c8e4d22ab839564da322fac
Autor:
Ariana Huebner, James R. M. Black, Francesca Sarno, Roberto Pazo, Ignacio Juez, Laura Medina, Rocio Garcia-Carbonero, Carmen Guillén, Jaime Feliú, Carolina Alonso, Carlota Arenillas, Ana Belén Moreno-Cárdenas, Helena Verdaguer, Teresa Macarulla, Manuel Hidalgo, Nicholas McGranahan, Rodrigo A. Toledo
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Liquid biopsies and the dynamic tracking of somatic mutations within circulating tumour DNA (ctDNA) can provide insight into the dynamics of cancer evolution and the intra-tumour heterogeneity that fuels treatment resistance. Howe
Externí odkaz:
https://doaj.org/article/21716a2b02ec46eb8dbe1a817c4a0bab
Autor:
Sugandha Bhatia, Jennifer H Gunter, Joshua T Burgess, Mark N Adams, Kenneth O'Byrne, Erik W Thompson, Pascal HG Duijf
Publikováno v:
Translational Oncology, Vol 37, Iss , Pp 101760- (2023)
Epithelial-mesenchymal plasticity (EMP) is a hallmark of cancer. By enabling cells to shift between different morphological and functional states, EMP promotes invasion, metastasis and therapy resistance. We report that near-diploid non-cancerous hum
Externí odkaz:
https://doaj.org/article/dffc9a60d0e54a2aa2cf2618bde6ad7a
Akademický článek
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Autor:
Eduardo Cararo Lopes, Akshada Sawant, Dirk Moore, Hua Ke, Fuqian Shi, Saurabh Laddha, Ying Chen, Anchal Sharma, Jake Naumann, Jessie Yanxiang Guo, Maria Gomez, Maria Ibrahim, Tracey L. Smith, Gregory M. Riedlinger, Edmund C. Lattime, Stanley Trooskin, Shridar Ganesan, Xiaoyang Su, Renata Pasqualini, Wadih Arap, Subhajyoti De, Chang S. Chan, Eileen White
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 6, Pp n/a-n/a (2023)
Abstract Background Differentiated thyroid cancer (DTC) affects thousands of lives worldwide each year. Typically, DTC is a treatable disease with a good prognosis. Yet, some patients are subjected to partial or total thyroidectomy and radioiodine th
Externí odkaz:
https://doaj.org/article/ec7a07680de6468dbc8e44b77ccb4981
Publikováno v:
EJC Supplements, Vol 15, Iss , Pp 16-26 (2020)
Background and purpose: Ovarian cancer (OC) is the deadliest gynaecologic cancer characterised by a high heterogeneity not only at the clinical point of view but also at the molecular level. This review focuses on the new insights about the OC molecu
Externí odkaz:
https://doaj.org/article/f6036d37a53a4125b667b2308bb373b2
Publikováno v:
Royal Society Open Science, Vol 9, Iss 1 (2022)
Single-cell genome sequencing has become a useful tool in medicine and biology studies. However, an independent library is required for each cell in single-cell genome sequencing, so that the cost grows with the number of cells. In this study, we rep
Externí odkaz:
https://doaj.org/article/3c80e89388f34b6a89122c722ab5b559
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Background: Oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC) are very common in head and neck malignancy. Intratumour heterogeneity (ITH) may hamper their responses to treatment. Hence, novel tumour sampling metho
Externí odkaz:
https://doaj.org/article/29604de616724094b23fe71c970dc30a
Autor:
Sabina Sangaletti, Fabio Iannelli, Federica Zanardi, Valeria Cancila, Paola Portararo, Laura Botti, Davide Vacca, Claudia Chiodoni, Arianna Di Napoli, Cesare Valenti, Celeste Rizzello, Maria Carmela Vegliante, Federica Pisati, Alessandro Gulino, Maurilio Ponzoni, Mario Paolo Colombo, Claudio Tripodo
Publikováno v:
EBioMedicine, Vol 61, Iss , Pp 103055- (2020)
Background: Intra-tumour heterogeneity in lymphoid malignancies encompasses selection of genetic events and epigenetic regulation of transcriptional programs. Clonal-related neoplastic cell populations are unsteadily subjected to immune editing and m
Externí odkaz:
https://doaj.org/article/662b10b597da49ab97d7a5c5e7f26f9e