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Limited stage high grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangements: BCL2 rearrangements drives the poor outcomes.

Autor: Lue JK; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. luej@mskcc.org., Luttwak E; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Rivas-Delgado A; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Irawan H; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Boardman A; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Caron PC; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., David K; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Epstein-Peterson Z; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Falchi L; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ghione P; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hamlin P; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Horwitz SM; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Intlekofer AM; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Johnson W; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kumar A; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Moskowitz A; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Noy A; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Palomba ML; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Steiner R; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Stuver R; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Torka P; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Vardhana S; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zelenetz AD; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Schoder H; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Imber B; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yahalom J; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zhang Y; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Galera P; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Dogan A; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Aypar U; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Salles G; Lymphoma Service, Division of Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Publikováno v: Blood cancer journal [Blood Cancer J] 2024 Oct 14; Vol. 14 (1), pp. 178. Date of Electronic Publication: 2024 Oct 14.

Emapalumab as salvage therapy for adults with malignancy-associated hemophagocytic lymphohistiocytosis.

Autor: Johnson WT; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY. Johnsow3@mskcc.org., Epstein-Peterson ZD; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Ganesan N; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY., Pak T; Department of Medicine, New York Presbyterian Brooklyn Methodist Hospital-Weill Cornell Medical College, New York, NY., Chang T; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY., Dao P; Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, NY., Moskowitz AJ; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Stuver RN; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Ghione P; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Galasso N; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY., Khan N; Department of Hematology and Hematopoietic Cell Transplant, Lymphoma Division, City of Hope Comprehensive Cancer, Duarte, CA., Palomba ML; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Caron PC; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Kumar A; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Tamari R; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY, USA; Department of Medicine, Adult Bone Marrow Transplant and Cellular Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY., Lue JK; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Noy A; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Falchi L; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Intlekofer AM; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY., Gyurkocza B; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY, USA; Department of Medicine, Adult Bone Marrow Transplant and Cellular Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY., Perales MA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY, USA; Department of Medicine, Adult Bone Marrow Transplant and Cellular Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY., Scordo M; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY, USA; Department of Medicine, Adult Bone Marrow Transplant and Cellular Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY., Herskovits AZ; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Salles G; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Vardhana SA; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY., Horwitz SM; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY.

Publikováno v: Haematologica [Haematologica] 2024 Sep 01; Vol. 109 (9), pp. 2998-3003. Date of Electronic Publication: 2024 Sep 01.

TP53 mutations identify high-risk events for peripheral T-cell lymphoma treated with CHOP-based chemotherapy.

Autor: Johnson WT; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Ganesan N; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY., Epstein-Peterson ZD; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Moskowitz AJ; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Stuver RN; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY., Maccaro CR; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY., Galasso N; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY., Chang T; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY., Khan N; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Aypar U; Department of Pathology, Cytogenetics Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY., Lewis NE; Department of Pathology, Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY., Zelenetz AD; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Palomba ML; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Matasar MJ; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Noy A; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Hamilton AM; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Hamlin P; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Caron PC; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Straus DJ; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Intlekofer AM; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY., Lee Batlevi C; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Kumar A; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Owens CN; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Sauter CS; Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH., Falchi L; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Lue JK; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Vardhana SA; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY., Salles G; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY., Dogan A; Department of Pathology, Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY., Schultz ND; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY., Arcila ME; Department of Pathology, Molecular Diagnostic Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY., Horwitz SM; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY.

Publikováno v: Blood advances [Blood Adv] 2023 Sep 12; Vol. 7 (17), pp. 5172-5186.

A multimodal atlas of tumour metabolism reveals the architecture of gene-metabolite covariation.

Autor: Benedetti E; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Institute of Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Liu EM; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tang C; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kuo F; Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Buyukozkan M; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Institute of Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Park T; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Park J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Correa F; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hakimi AA; Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Intlekofer AM; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Krumsiek J; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. jak2043@med.cornell.edu.; Institute of Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA. jak2043@med.cornell.edu.; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA. jak2043@med.cornell.edu., Reznik E; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. reznike@mskcc.org.; Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. reznike@mskcc.org.; Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. reznike@mskcc.org.

Publikováno v: Nature metabolism [Nat Metab] 2023 Jun; Vol. 5 (6), pp. 1029-1044. Date of Electronic Publication: 2023 Jun 19.