Výsledky vyhledávání - "Intisar Husain"

Purification and Characterization of DNA Ligase III from Bovine Testes

Autor: Mary B. Moyer, Jeffrey M. Besterman, Jingwen Chen, Intisar Husain, William Burkhart, Alan E. Tomkinson, William Ramos, Zachary B. Mackey

Publikováno v: Journal of Biological Chemistry. 270:9683-9690

Mammalian cell nuclei contain three biochemically distinct DNA ligases. In the present study we have found high levels of DNA ligase I and DNA ligase III activity in bovine testes and have purified DNA ligase III to near homogeneity. The high level o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8183643ad60b4def5d484845360bd36c
https://doi.org/10.1074/jbc.270.16.9683

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A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer

Autor: Patricia Trusk, Sarah S. Bacus, Jennifer L. Harris, Georgina Paulazzo, Jay C. Strum, Leihua Liu, Neil L. Spector, Intisar Husain, Jason Hill, Priti S. Hegde, Ljuba Lyass, Wenle Xia

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 103(20)

The development of acquired resistance to ErbB2 tyrosine kinase inhibitors limits the clinical efficacy of this class of cancer therapeutics. Little is known about the mechanism(s) of acquired resistance to these agents. Here we establish a model of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ba25c2e0214e5ed3d3e5c41d677eb7
https://pubmed.ncbi.nlm.nih.gov/16682622

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Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

Autor: Huiyun Wu, Intisar Husain, John P. Cogswell, Christopher W. Conn, Suqing Xie, Meena Jhanwar-Uniyal, Wei Dai, Qi Wang, Peter J. Stambrook

Publikováno v: The Journal of biological chemistry. 276(46)

Polo-like kinase 3 (Plk3, previously termed Prk) contributes to regulation of M phase of the cell cycle (Ouyang, B., Pan, H., Lu, L., Li, J., Stambrook, P., Li, B., and Dai, W. (1997) J. Biol. Chem. 272, 28646-28651). Plk3 physically interacts with C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb68ef1eb56725b0fa1ec40fb44be005
https://pubmed.ncbi.nlm.nih.gov/11551930

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DNA polymerase beta expression differences in selected human tumors and cell lines

Autor: Carlos L. Arteaga, Deepak K. Srivastava, Intisar Husain, Samuel H. Wilson

Publikováno v: Carcinogenesis. 20(6)

A long-standing question in cancer biology has been the extent to which DNA repair may be altered during the process of carcinogenesis. We have shown recently that DNA polymerase beta (beta-pol) provides a rate-determining function during in vitro re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1206a6416b0fdb768c316b2b21b8cb
https://pubmed.ncbi.nlm.nih.gov/10357787

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Cellular Functions of Mammalian DNA Ligases

Autor: Intisar Husain, Jeff Besterman, Jingwen Chen, Alan E. Tomkinson

Publikováno v: DNA Damage and Repair ISBN: 9781475750157

DNA strand breaks, in particular double-strand breaks, are potentially cytotoxic lesions. These breaks may be introduced directly by a DNA-damaging agent, such as ionizing radiation, or as a consequence of DNA repair proteins recognizing and excising

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9ccffe131010d540b89a43cce11651
https://doi.org/10.1007/978-1-59259-455-9_12

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Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination

Autor: Intisar Husain, Jeffrey M. Besterman, Christi A Walter, Jingwen Chen, Zachary B. Mackey, A. E. Tomkinson, R. A. Schultz, S. Danehower, W. Ramos

Publikováno v: Scopus-Elsevier

Three biochemically distinct DNA ligase activities have been identified in mammalian cell extracts. We have recently purified DNA ligase II and DNA ligase III to near homogeneity from bovine liver and testis tissue, respectively. Amino acid sequencin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f9935cddda9f209d5f5881924dc6f1
https://pubmed.ncbi.nlm.nih.gov/7565692

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Specific inhibition of DNA polymerase beta by its 14 kDa domain: role of single- and double-stranded DNA binding and 5'-phosphate recognition

Autor: Jeffrey M. Besterman, Bradley Morton, William A. Beard, Rakesh K. Singhal, Samuel H. Wilson, Rajendra Prasad, Intisar Husain

DNA polymerase beta (beta-polymerase) has been implicated in short-patch DNA synthesis in the DNA repair pathway known as base excision repair. The native 39 kDa enzyme is organized into four structurally and functionally distinct domains. In an effo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a147a55cd72631fa7440d5c410e12d
https://europepmc.org/articles/PMC306903/

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Sequence effect on incision by (A)BC excinuclease of 4NQO adducts and UV photoproducts

Autor: D C Thomas, G. B. Panigrahi, Intisar Husain, Stephen G. Chaney, Ian G. Walker

Publikováno v: Nucleic acids research. 19(2)

Nucleotide excision repair in Escherichia coli is initiated by (A)BC excinuclease, an enzyme which incises DNA on both sides of bulky adducts and removes the damaged nucleotide as a 12-13 base long oligomer. The incision pattern of the enzyme was exa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c553573d024c04a171b972534c12cc8
https://pubmed.ncbi.nlm.nih.gov/1901645

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