Role of Transient Receptor Potential Vanilloid 4 Channel in Skin Physiology and Pathology

Autor: Ammar Boudaka, Mallak Al-Yazeedi, Intisar Al-Lawati

Publikováno v: Sultan Qaboos University Medical Journal, Vol 20, Iss 2, Pp e138-e138 (2020)

Transient receptor potential vanilloid 4 (TRPV4) channel responds to temperature, as well as various mechanical and chemical stimuli. This non-selective cation channel is expressed in several organs, including the blood vessels, kidneys, oesophagus a

Externí odkaz: https://doaj.org/article/c063ed0a65b4465796aafd5750620b8e

Ileal Motility pattern In a Mouse Disease Model of Ulcerative Colitis

Autor: Intisar Al Lawati, Ammar Boudaka, Khalil Ibrahim Salim Al Ajmi, Suaad Al Mandhari, Adel Ahmidat

Publikováno v: Biomedical Journal of Scientific & Technical Research. 32

The small intestine is the longest part of the gastrointestinal tract and is about 20 feet long...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa549143b90c3bc79ac55a91937cbe37
https://doi.org/10.26717/bjstr.2021.32.005327

Systemic Oxidative Stress Is Increased in Postmenopausal Women and Independently Associates with Homocysteine Levels

Autor: Harry van Goor, Amaal Eman Abdulle, Sanne J. Gordijn, Marian Bulthuis, Sultan Al-Siyabi, Marvin B Enriquez, Mohsin Al-Saleh, Areej M Al-Rawas, Intisar Al-Lawati, Khamis Al-Hashmi, Jumana Saleh, Arno R. Bourgonje, Muna Al-Maqbali, Douwe J. Mulder

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 1
International Journal of Molecular Sciences, 21(1):314. MDPI AG
International Journal of Molecular Sciences, Vol 21, Iss 1, p 314 (2020)

Oxidative stress plays a pivotal role in the pathogenesis of cardiovascular diseases (CVD). Postmenopausal women have an increased risk of developing CVD due to decreased estrogen availability, which is accompanied by increased oxidative stress. Seru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacdb5cd5a5a7f3b3f4ea0b3ef4c43ac
https://doi.org/10.3390/ijms21010314

Aging Reduces L-Type Calcium Channel Current and the Vasodilatory Response of Small Mesenteric Arteries to Calcium Channel Blockers

Autor: Al-Manar Al-Busaidi, Fathi Mansour, Musbah O Tanira, Isehaq Al-Husseini, Sulayma Albarwani, Sultan Al-Siyabi, Abdul Aleem Khan, Abdulla Al-Kaabi, Safa Al-Hadhrami, Intisar Al-Lawati

Publikováno v: Frontiers in Physiology
Frontiers in Physiology, Vol 7 (2016)

Calcium channel blockers are widely used to treat cardiovascular disease (CVD) including hypertension. As aging is an independent risk factor for CVD, the use of calcium channel blockers increases with increasing age. Hence, this study was designed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7c7404b33a63a5feb5d4d3018d62e5
http://europepmc.org/articles/PMC4873501

Abrogation of cisplatin-induced nephrotoxicity by emodin in rats

Autor: Intisar Al-Lawati, Isehaq S. Al Husseini, Suhail Al-Salam, Badreldin H. Ali, Abderrahim Nemmar, Mohamed A. Fahim, Mostafa I. Waly, Javed Yasin

Publikováno v: Fundamental & Clinical Pharmacology. 27:192-200

Nephrotoxicity of the anticancer drug cisplatin (CP) involves the generation of reactive oxygen species in renal cortex, and emodin (a rhubarb anthraquinone) has strong antioxidant and anticancer actions. Therefore, we tested here the possible amelio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bb1ea63f7683300503381fcf20b5793
https://doi.org/10.1111/j.1472-8206.2011.01003.x