Zobrazeno 1 - 10
of 369
pro vyhledávání: '"Inti, Zlobec"'
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin M Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Godsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2233-2261 (2024)
Abstract We have developed and validated a highly specific, versatile antibody to the extracellular domain of human LGR5 (α-LGR5). α-LGR5 detects LGR5 overexpression in >90% of colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pre-B-ALL t
Externí odkaz:
https://doaj.org/article/4df981d9b6cb481e9115536caaf2c410
Autor:
Hannah L. Williams, Ana Leni Frei, Thibaud Koessler, Martin D. Berger, Heather Dawson, Olivier Michielin, Inti Zlobec
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-18 (2024)
Abstract Enabling the examination of cell-cell relationships in tissue, spatially resolved omics technologies have revolutionised our perspectives on cancer biology. Clinically, the development of immune checkpoint inhibitors (ICI) has advanced cance
Externí odkaz:
https://doaj.org/article/f2ef085cd2a340bbb4523c525e173237
Autor:
Pedro C. Neto, Diana Montezuma, Sara P. Oliveira, Domingos Oliveira, João Fraga, Ana Monteiro, João Monteiro, Liliana Ribeiro, Sofia Gonçalves, Stefan Reinhard, Inti Zlobec, Isabel M. Pinto, Jaime S. Cardoso
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-15 (2024)
Abstract Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL) s
Externí odkaz:
https://doaj.org/article/91253dbe2b0841d8ae5dbc0c4080a147
Autor:
Jonathan TC Liu, Sarah SL Chow, Richard Colling, Michelle R Downes, Xavier Farré, Peter Humphrey, Andrew Janowczyk, Tuomas Mirtti, Clare Verrill, Inti Zlobec, Lawrence D True
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 1, Pp n/a-n/a (2024)
Abstract In recent years, technological advances in tissue preparation, high‐throughput volumetric microscopy, and computational infrastructure have enabled rapid developments in nondestructive 3D pathology, in which high‐resolution histologic da
Externí odkaz:
https://doaj.org/article/ae2382569a7a4659b6ce5953678b78d0
Autor:
Pedro C. Neto, Diana Montezuma, Sara P. Oliveira, Domingos Oliveira, João Fraga, Ana Monteiro, João Monteiro, Liliana Ribeiro, Sofia Gonçalves, Stefan Reinhard, Inti Zlobec, Isabel M. Pinto, Jaime S. Cardoso
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f41ae9b2d6a344408f12aa33237040ed
Autor:
Joe Yeong, Bernett Lee, Inti Zlobec, Jeffrey Lim, Mai Chan Lau, Felicia Wee, Chan Way Ng, Xinyun Feng, Marcia Zhang, Willa Yim, Menaka Priyadharsani Rajapakse, Olaf Rotzchke
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/8874c5a196ff4377858254b151b596a6
Autor:
Inti Zlobec, David Dorward, Samuel Pattle, Daniela F Rodrigues, Christina Neppl, Tereza Losmanová, Rebecca Wyatt, Donna Mulkern, Raphaël Oberson, Stefan Reinhard, Therese Waldburger, Peter Caie
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/da70c0c0cb6042bb912c4c3fea6b5a2e
Autor:
Magdalena Skoworonska, Annika Blank, Irene Centeno, Caroline Hammer, Aurel Perren, Inti Zlobec, Tilman T Rau
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 2, Pp 137-148 (2023)
Abstract The standardized preanalytical code (SPREC) aggregates warm ischemia (WIT), cold ischemia (CIT), and fixation times (FIT) in a precise format. Despite its growing importance underpinned by the European in vitro diagnostics regulation or broa
Externí odkaz:
https://doaj.org/article/b8e573fe261f4c1ea76735c57e61326c
Autor:
L. Paige Ferguson, Jovylyn Gatchalian, Matthew L. McDermott, Mari Nakamura, Kendall Chambers, Nirakar Rajbhandari, Nikki K. Lytle, Sara Brin Rosenthal, Michael Hamilton, Sonia Albini, Martin Wartenberg, Inti Zlobec, José A. Galván, Eva Karamitopoulou, Vera Vavinskaya, Alexis Wascher, Andrew M. Lowy, Christian M. Schürch, Pier Lorenzo Puri, Benoit G. Bruneau, Diana C. Hargreaves, Tannishtha Reya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Clinical management of pancreatic cancer remains challenging. Here, the authors suggest SMARCD3 as a potential epigenetic dependency establishing the metabolic landscape in aggressive pancreatic cancer cells and as a potential therapeutic target in p
Externí odkaz:
https://doaj.org/article/eadb3f5725a947ddb9882b3a7d976ccc
Autor:
Luca Noti, José A. Galván, Heather Dawson, Alessandro Lugli, Richard Kirsch, Naziheh Assarzadegan, David Messenger, Philippe Krebs, Martin D. Berger, Inti Zlobec
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Previous assessments of peritumoral inflammatory infiltrate in colorectal cancer (CRC) have focused on the role of CD8+ T lymphocytes. We sought to compare the prognostic value of CD8 with downstream indicators of active immune ce
Externí odkaz:
https://doaj.org/article/cfbc8f10d8a7441da59d8e0291493ca3