Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Intestinal Mucosa/drug effects"'
1
Development of a self-limiting model of methotrexate-induced mucositis reinforces butyrate as a potential therapy
Autor: da Silva Ferreira, A R, van der Aa, S A J, Wehkamp, T, Wardill, H R, Ten Klooster, J P, Garssen, J, Harthoorn, L F, Hartog, A, Harmsen, H J M, Tissing, W J E, van Bergenhenegouwen, J, Afd Pharmacology, Pharmacology
Publikováno v: Scientific Reports, 11(1), 1. NLM (Medline)
Scientific Reports
Scientific Reports, 11:22911. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific reports
Background: Gastrointestinal mucositis remains a significant complication of anticancer treatment, with limited anti-mucositis interventions. Currently, there are few validated in vitro systems suitable to study the mechanisms of mucosal injury. Ther
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f0be1bb49864df41a96eba18f87645
https://dspace.library.uu.nl/handle/1874/419704
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2
SIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal-stem-cell survival
Autor: Yuanchuang Li, Junjie Peng, Xinxin Rao, Shaobo Mo, Jun Gao, Guoqiang Hua, Jianjun Gao, Mengxue Pan, Yi Zhou, Ye Yao, Sanjun Cai, Shengzhi Chen, Peiyuan Tang, Guoxiang Fu, Xiaoya Xu, Xiaomeng Li, Hans Clevers, Zhen Zhang, Liping Liang
Publikováno v: Cancer letters, 501, 20-30
High-dose radiation exposure induces gastrointestinal (GI) stem cell death, resulting in denudation of the intestinal mucosa and lethality from GI syndrome, for which there is currently no effective therapy. Studying an intestinal organoid-based func
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a409d8b4f8ffbd9c67fa00807dad3fd3
https://pubmed.ncbi.nlm.nih.gov/33359449
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4
Early Antiretroviral Therapy Preserves Functional Follicular Helper T and HIV-Specific B Cells in the Gut Mucosa of HIV-1-Infected Individuals
Autor: Valérie Lorin, Mathieu Surenaud, Cyril Planchais, Hugo Mouquet, Mathieu Fusaro, Sophie Hue, Marie-Hélène Delfau-Larue, Nabila Seddiki, Clara Ibanez, Laurent Hocqueloux, Michael J. Levy, Thierry Prazuck, S. Gallien, Yves Levy, Ayrin Kök, Christiane Copie, Jean-Daniel Lelièvre, Laurent Lefrou
Publikováno v: Journal of Immunology
Journal of Immunology, 2018, 200 (10), pp.3519-3529. ⟨10.4049/jimmunol.1701615⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2018, 200 (10), pp.3519-3529. ⟨10.4049/jimmunol.1701615⟩
HIV-1 infection is associated with B cell dysregulation and dysfunction. In HIV-1–infected patients, we previously reported preservation of intestinal lymphoid structures and dendritic cell maturation pathways after early combination antiretroviral
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2622102e5901a8a1bf6c99603c6ba9c4
https://hal-pasteur.archives-ouvertes.fr/pasteur-02634634/document
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5
Does oral exposure to cadmium and lead mediate susceptibility to colitis? The dark-and-bright sides of heavy metals in gut ecology
Autor: Jérôme Breton, Anne Garat, Mathilde Body-Malapel, Coline Plé, Benoît Foligné, Cécile Vignal, Catherine Daniel
Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, Scientific Reports, 6, ⟨10.1038/srep19200⟩
Scientific Reports, Nature Publishing Group, 2016, Scientific Reports, 6 (1), pp.19200. ⟨10.1038/srep19200⟩
Scientific Reports, 2016, Scientific Reports, 6, ⟨10.1038/srep19200⟩
Although the heavy metals cadmium (Cd) and lead (Pb) are known environmental health concerns, their long-term impacts on gut ecology and susceptibility to gastrointestinal autoimmune diseases have not been extensively investigated. We sought to deter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c7cc50d8e154808025df61383bfe2a
https://hal.archives-ouvertes.fr/hal-01935794
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6
Animal models of chemotherapy-induced mucositis: translational relevance and challenges
Autor: Peter Erik Lotko Pontoppidan, René Liang Shen, Per T. Sangild, Mathias Rathe
Publikováno v: Sangild, P T, Shen, R L, Pontoppidan, P E L & Rathe, M 2018, ' Animal Models of Chemotherapy-induced Mucositis : Translational Relevance and Challenges ', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 314, no. 2, pp. G231-G246 . https://doi.org/10.1152/ajpgi.00204.2017
Chemotherapy for cancer patients induces damaging tissue reactions along the epithelium of the gastrointestinal tract (GIT). This chemotherapy-induced mucositis (CIM) is a serious side effect of cytotoxic drugs, and several animal models of CIM have
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbde4aa8a8cde1d5478c98d21b6c69dc
https://pubmed.ncbi.nlm.nih.gov/29074485
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7
Gut: An underestimated target organ for Aluminum
Autor: Mathilde Body-Malapel, Pierre Desreumaux, Cécile Vignal
Publikováno v: Morphologie
Morphologie, Elsevier Masson, 2016, 100 (329), pp.75-84. ⟨10.1016/j.morpho.2016.01.003⟩
Morphologie, Elsevier Masson, 2016, Morphologie, 100, pp.75-84. ⟨10.1016/j.morpho.2016.01.003⟩
Morphologie, 2016, Morphologie, 100, pp.75-84. ⟨10.1016/j.morpho.2016.01.003⟩
International audience; Since World War II, several factors such as an impressive industrial growth, an enhanced environmental bioavailability and intensified food consumption have contributed to a significant amplification of human exposure to alumi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0c099303a7207dccb41f8cbf315bfb
https://hal.archives-ouvertes.fr/hal-01935789
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8
Toxicological consequences of experimental exposure to aluminum in human intestinal epithelial cells
Autor: Cécile Vignal, Pierre Desreumaux, Madjid Djouina, Nicolas Esquerre, Mathilde Body-Malapel
Publikováno v: Food and Chemical Toxicology
Food and Chemical Toxicology, Elsevier, 2016, 91, pp.108-116. ⟨10.1016/j.fct.2016.03.008⟩
Food and Chemical Toxicology, Elsevier, 2016, Food and Chemical Toxicology, 91, pp.108-116. ⟨10.1016/j.fct.2016.03.008⟩
Food and Chemical Toxicology, 2016, Food and Chemical Toxicology, 91, pp.108-116. ⟨10.1016/j.fct.2016.03.008⟩
International audience; Aluminum (Al), a non-essential element, is ubiquitous in industrialized societies. Whereas adult intake is estimated between 3 and 12 mg/day according to dietary aluminum studies conducted in many countries, it is not known if
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a951aa50bfd6f2de9730d8ec0d1a53a
https://hal.archives-ouvertes.fr/hal-01935784
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9
Doxorubicin-Induced Gut Toxicity in Piglets Fed Bovine Milk and Colostrum
Autor: Peter Erik Lotko Pontoppidan, Per T. Sangild, René Liang Shen, Peter M. H. Heegaard, Klaus Müller, Pingping Jiang, Mathias Rathe
Publikováno v: Shen, R L, Rathe, M, Jiang, P, Pontoppidan, P E L, Heegaard, P M H, Müller, K & Sangild, P T 2016, ' Doxorubicin-Induced Gut Toxicity in Piglets fed Bovine Milk and Colostrum ', Journal of Pediatric Gastroenterology and Nutrition, vol. 63, no. 6, pp. 698-707 . https://doi.org/10.1097/MPG.0000000000001205
Objective: Chemotherapy-induced intestinal toxicity is a common adverse effect of cancer treatment.Wehypothesized that a milk diet containing bovine colostrum(BC)would reduce intestinal toxicity in doxorubicin-treated piglets. Methods: ''Study 1'' in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0dd23b9d7cefa43cb8bf2c28ba96c1a
https://pubmed.ncbi.nlm.nih.gov/27027906
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10
Intrinsic immunomodulatory effects of low-digestible carbohydrates selectively extend their anti-inflammatory prebiotic potentials
Autor: Jérôme Breton, Bruno Pot, Laetitia Guérin-Deremaux, Catherine Lefranc-Millot, Coline Plé, Daniel Wils, Benoît Foligné
Publikováno v: BioMed Research International, Vol 2015 (2015)
BioMed Research International
The beneficial effects of carbohydrate-derived fibers are mainly attributed to modulation of the microbiota, increased colonic fermentation, and the production of short-chain fatty acids. We studied the direct immune responses to alimentary fibers in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913c330b0c13f9560c5c1fa1420e1c6f
https://hdl.handle.net/20.500.14017/49e0f06b-9567-47b4-8017-90a75277e9fb
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