Aberrant Epithelial Differentiation Contributes to Pathogenesis in a Murine Model of Congenital Tufting EnteropathySummary

Autor: Barun Das, Kevin Okamoto, John Rabalais, Jocelyn A. Young, Kim E. Barrett, Mamata Sivagnanam

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1353-1371 (2021)

Background & Aims: Congenital tufting enteropathy (CTE) is an intractable diarrheal disease of infancy caused by mutations of epithelial cell adhesion molecule (EpCAM). The cellular and molecular basis of CTE pathology has been elusive. We hypothesiz

Externí odkaz: https://doaj.org/article/5801d138dcd94c91adee3f5dcbc1d252

Aberrant Epithelial Differentiation Contributes to Pathogenesis in a Murine Model of Congenital Tufting EnteropathySummary

Autor: Kim E. Barrett, Mamata Sivagnanam, Jocelyn Young, Barun Das, Kevin Okamoto, John Rabalais

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1353-1371 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Congenital tufting enteropathy (CTE) is an intractable diarrheal disease of infancy caused by mutations of epithelial cell adhesion molecule (EpCAM). The cellular and molecular basis of CTE pathology has been elusive. We hypothesize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd57cdfe5b62c31ab3e478c97bd8551
http://www.sciencedirect.com/science/article/pii/S2352345X21001302

Lipid Messenger Phosphatidylinositol-4,5-Bisphosphate Is Increased by Both PPARα Activators and Inhibitors: Relevance for Intestinal Cell Differentiation

Autor: Zdeněk Tauber, Katerina Cizkova, Katerina Koubova

Publikováno v: Biology; Volume 11; Issue 7; Pages: 997

We investigated the effects of PPARα activators fenofibrate and WY-14643 as well as the PPARα inhibitor GW6471 on the PI3K/Akt/PTEN pathway of intestinal cell differentiation. Our previous study showed that all these compounds increased the express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46272d975806644c7941946adc987b0b
https://doi.org/10.3390/biology11070997

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Enterocytic differentiation is modulated by lipid rafts-dependent assembly of adherens junctions

Autor: Nicolas T. Chartier, Bruno Bonaz, Christiane Oddou, Benjamin Ducarouge, M. Laine, Corinne Albiges-Rizo, Muriel R. Jacquier-Sarlin

Publikováno v: Experimental Cell Research
Experimental Cell Research, Elsevier, 2011, 317 (10), pp.1422-36. ⟨10.1016/j.yexcr.2011.03.009⟩

International audience; Integrity of the epithelial barrier is determined by apical junctional complexes which also participate in the signalling pathways inducing intestinal cell differentiation. Lipid rafts (LR) have been proposed to play a role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f135e97bf4a10b78ebef541044a421d5
https://www.hal.inserm.fr/inserm-00668336/file/Chartier_Enterocytic_2011_AA.pdf