Identification of an archaeal maltooligosyltrehalose trehalohydrolase encoded by an interrupted gene

Autor: Ye Zhou, Lin Chang, Guiqiu Xie, Wang Yan, Renjun Gao

Publikováno v: Extremophiles. 21:537-549

Complete genome analysis of the thermoacidophilic Archaeon Sulfolobus tokodaii strain 7 revealed two open reading frames (ORF), namely, ST0926 and ST0927. These ORFs are interrupted by two putative insertions and encode for the N- and C-terminal frag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19971502d050edb117f1d0a2d06eab27
https://doi.org/10.1007/s00792-017-0923-5

DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon–intron structure

Autor: Sahar Gelfman, Noa Cohen, Ahuvi Yearim, Gil Ast

Publikováno v: Genome Research. 23:789-799

DNA methylation is known to regulate transcription and was recently found to be involved in exon recognition via cotranscriptional splicing. We recently observed that exon–intron architectures can be grouped into two classes: one with higher GC con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09d31c9dd80036135b03162a4f59c64
https://doi.org/10.1101/gr.143503.112

Changes in exon–intron structure during vertebrate evolution affect the splicing pattern of exons

Autor: Tal Pupko, Osnat Penn, David Burstein, Gil Ast, Maayan Amit, Anna Savchenko, Sahar Gelfman, Schraga Schwartz

Publikováno v: Genome Research. 22:35-50

Exon–intron architecture is one of the major features directing the splicing machinery to the short exons that are located within long flanking introns. However, the evolutionary dynamics of exon–intron architecture and its impact on splicing is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f6304b04bd1efb5ac3c0632e567094
https://doi.org/10.1101/gr.119834.110

Evolution of introns in the archaeal world

Autor: Glauco P. Tocchini-Valentini, Giuseppe D. Tocchini-Valentini, Paolo Fruscoloni

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 108 (2011): 4782–4787. doi:10.1073/pnas.1100862108
info:cnr-pdr/source/autori:Tocchini-Valentini G.D.; Fruscoloni P.; Tocchini-Valentini G.P./titolo:Evolution of introns in the archaeal world./doi:10.1073%2Fpnas.1100862108/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2011/pagina_da:4782/pagina_a:4787/intervallo_pagine:4782–4787/volume:108

The self-splicing group I introns are removed by an autocatalytic mechanism that involves a series of transesterification reactions. They require RNA binding proteins to act as chaperones to correctly fold the RNA into an active intermediate structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2dc47aec999107e53fdae00faae532
https://doi.org/10.1073/pnas.1100862108

The pathobiology of splicing

Autor: Amanda J. Ward, Thomas A. Cooper

Publikováno v: The Journal of Pathology. 220:152-163

Ninety-four percent of human genes are discontinuous, such that segments expressed as mRNA are contained within exons and separated by intervening segments, called introns. Following transcription, genes are expressed as precursor mRNAs (pre-mRNAs),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43137b798c36b7bb9a6afa244672d581
https://doi.org/10.1002/path.2649