Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma

Autor: Liang, Huan-Chang, Costanza, Mariantonia, Prutsch, Nicole, Zimmerman, Mark W., Gurnhofer, Elisabeth, Montes-Mojarro, Ivonne A., Abraham, Brian J., Prokoph, Nina, Stoiber, Stefan, Tangermann, Simone, Lobello, Cosimo, Oppelt, Jan, Anagnostopoulos, Ioannis, Hielscher, Thomas, Pervez, Shahid, Klapper, Wolfram, Zammarchi, Francesca, Silva, Daniel-Adriano, Garcia, K. Christopher, Baker, David, Janz, Martin, Schleussner, Nikolai, Fend, Falko, Pospíšilová, Šárka, Janiková, Andrea, Wallwitz, Jacqueline, Stoiber, Dagmar, Simonitsch-Klupp, Ingrid, Cerroni, Lorenzo, Pileri, Stefano, de Leval, Laurence, Sibon, David, Fataccioli, Virginie, Gaulard, Philippe, Assaf, Chalid, Knörr, Fabian, Damm-Welk, Christine, Woessmann, Wilhelm, Turner, Suzanne D., Look, A. Thomas, Mathas, Stephan, Kenner, Lukas, Merkel, Olaf

Publikováno v: Nature communications, vol. 12, no. 1, pp. 5577
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis of some ALCL subgroups

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a2422edb39fce227889a8f8c1af0c166
https://www.repository.cam.ac.uk/handle/1810/328381

An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment

Autor: Polychronis Pavlidis, Giovanna Lombardi, Leena Halim, Sophia N. Karagiannis, Isabel Correa, Rosalind F. Hannen, Reuben McGregor, Nick Powell, Nathali Grageda, Wayel Jassem, Robert I. Lechler, Mark Ong, Muhammed Yuksel, Bu'Hussain Hayee, Estefania Nova-Lamperti, Marco Romano, Olivia Mckinney, Sec-Julie Hoong

Publikováno v: Halim, L, Romano, M, McGregor, R, Correa, I, Pavlidis, P, Grageda, N, Hoong, S-J, Yuksel, M, Jassem, W, Hannen, R F, Ong, M, Mckinney, O, Hayee, BH, Karagiannis, S N, Powell, N, Lechler, R I, Nova-Lamperti, E & Lombardi, G 2017, ' An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment ', Cell Reports, vol. 20, no. 3, pp. 757-770 . https://doi.org/10.1016/j.celrep.2017.06.079
Cell Reports
Cell Reports, Vol 20, Iss 3, Pp 757-770 (2017)

Summary Regulatory T cells (Tregs) play a pivotal role in maintaining immunological tolerance, but they can also play a detrimental role by preventing antitumor responses. Here, we characterized T helper (Th)-like Treg subsets to further delineate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48c709ab502ba4c04f1e2708d1ee298
https://doi.org/10.1016/j.celrep.2017.06.079

The Wiskott-Aldrich syndrome protein is required for the function of CD4+CD25+Foxp3+ regulatory T cells

Autor: Vinicius Cotta-de-Almeida, Fuminao Takeshima, Scott B. Snapper, Atul K. Bhan, Pierre Michetti, Michel H. Maillard, Deanna D. Nguyen, Cathryn R. Nagler

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 204, no. 2, pp. 381-91

The Wiskott-Aldrich syndrome, a primary human immunodeficiency, results from defective expression of the hematopoietic-specific cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASP). Because CD4+CD25+Foxp3+ naturally occurring regulatory T (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0333280b48587c61bd2a87aebe45f681
http://europepmc.org/articles/PMC2118715

Experimental isolation and transplantation of hepatocytes with the use of antibody against interleukin-2 receptor (daclizumab) as immunosuppressive agent

Autor: M. Kontogiorgi, D. Dimitroulopoulos, I. Tsiolis, L. Papadimitriou, I. Papadimitriou, I. Vassiliou, E. Felekouras, E Lykoudis, I. Loukopoulos, I. Sfiniadakis, E. Theodossopoulou, A. Chairakakis, A. Papalois, A. Gravvanis, P. Dedeilias

Publikováno v: Transplantation proceedings. 37(4)

INTRODUCTION: Daclizumab (Dmab) is a genetically engineered humanized IgG1 monoclonal antibody that binds to the alpha chain of the interleukin-2 receptor (Tac, CD25, p55) expressed on activated human T lymphocytes. Dmab has been used in a clinical p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da8608ced9ef8781eae0197c6a8ce0a
https://pubmed.ncbi.nlm.nih.gov/15919507

Papel da atividade física regular realizada durante vários anos na função imune do idoso

Autor: Milton Hideaki Arai

Publikováno v: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.

A proposta principal deste estudo foi de avaliar o efeito da prática regular de atividade física por longos anos na imunossenescência, isto é, nas alterações que o sistema imune sofre com o envelhecimento. Para tal, comparou-se os resultados do

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/5/5144/tde-14102014-093413/