Zobrazeno 1 - 10
of 18 865
pro vyhledávání: '"Interleukin 12"'
Autor:
Bostjan Markelc, Tanja Jesenko, Simona Kranjc Brezar, Masa Omerzel, Ursa Lampreht Tratar, Andrej Rencelj, Urska Matkovic, Katarina Znidar, Spela Kos, Kristina Levpuscek, Ziva Pisljar, Ursa Kesar, Tilen Komel, Tim Bozic, Aneja Tuljak, Rosana Hudej, Matjaz Peterka, Urska Kamensek, Andrej Cör, Gorana Gasljevic, Alenka Nemec Svete, Natasa Tozon, Gregor Sersa, Maja Cemazar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Immunotherapeutic drugs are promising medicines for cancer treatment. A potential candidate for immunotherapy is interleukin-12 (IL-12), a cytokine well known for its ability to mediate antitumor activity. We developed a plasmid encoding hum
Externí odkaz:
https://doaj.org/article/31c16b9fe1ca4c038f2fb6e10cd7146e
Autor:
Jean Massaad, Michèle Magremanne
Publikováno v:
Heliyon, Vol 10, Iss 20, Pp e38566- (2024)
MRONJ is a well-known side effect of antiresorptive and antiangiogenic drug treatment. Crohn's disease involves pro-inflammatory interleukins IL-12 and IL-23. Ustekinumab is a targeted therapy antagonist of the p40 subunit of IL-12 and -23 indicated
Externí odkaz:
https://doaj.org/article/58af45ed1a2a4cd1abc00c80e4d2983b
Autor:
Wei Zhu, Mingxia Shao, Chao Tian, Jianshuai Yang, Hua Zhou, Jiajia Liu, Chunyang Sun, Min Liu, Jinyu Wang, Lijun Wei, Shuzhen Li, Xiaopeng Li, Jingfeng Li
Publikováno v:
Translational Oncology, Vol 46, Iss , Pp 102020- (2024)
This study investigated the synergistic potential of an oncolytic herpes simplex virus armed with interleukin 12 (VT1092M) in combination with immune checkpoint inhibitors for enhancing antitumor responses. The potential of this combination treatment
Externí odkaz:
https://doaj.org/article/57545b843a3c4f719dfb2ff7c6dbd73c
Autor:
Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Maite Alvarez, Ángela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Nuria Ardaiz, Alvaro Teijeira, Elixabet Bolaños, José González-Gomariz, Itziar Otano, Fernando Aranda, Belén Palencia, Aina Segués, Shuyu Huang, Sander M.J. van Duijnhoven, Andrea van Elsas, Ignacio Melero, Pedro Berraondo
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 599-616 (2023)
IL-12 is a potent cytokine for cancer immunotherapy. However, its systemic delivery as a recombinant protein has shown unacceptable toxicity in the clinic. Currently, the intratumoral injection of IL-12-encoding mRNA or DNA to avoid such side effects
Externí odkaz:
https://doaj.org/article/b7ab44ddf91c4d09a6a701937d803612
Autor:
Paul G. Pavicic, Patricia A. Rayman, Shadi Swaidani, Amit Rupani, Vladimir Makarov, Charles S. Tannenbaum, Robert P. Edwards, Anda M. Vlad, C. Marcela Diaz-Montero, Haider Mahdi
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTThe tumor microenvironment (TME) in ovarian cancer (OC) is characterized by immune suppression, due to an abundance of suppressive immune cells populations. To effectively enhance the activity of immune checkpoint inhibition (ICI), there is a
Externí odkaz:
https://doaj.org/article/5b7a38e7bf7d49fea8f8e68b5ef7c651
Autor:
Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Ángela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Irene Olivera, Elizabeth Bolaños, José González-Gomariz, Maite Álvarez, Iñaki Etxeberria, Belen Palencia, Álvaro Teijeira, Ignacio Melero, Pedro Berraondo, Fernando Aranda
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTPrevious studies have shown that local delivery of tumor antigen-specific CD8+ T lymphocytes engineered to transiently express single-chain IL-12 mRNA is highly efficacious. Peritoneal dissemination of cancer is a frequent and often fatal pat
Externí odkaz:
https://doaj.org/article/7995ddacfe9f449ca1ff8dccf0f9a256
Autor:
Katarzyna Węgierek-Ciura, Jagoda Mierzejewska, Agnieszka Szczygieł, Joanna Rossowska, Anna Wróblewska, Marta Świtalska, Tomasz M. Goszczyński, Bożena Szermer-Olearnik, Elżbieta Pajtasz-Piasecka
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe tumor microenvironment (TME) provides a conducive environment for the growth and survival of tumors. Negative factors present in TME, such as IL-10, may limit the effectiveness of cellular vaccines based on dendritic cells, therefore, i
Externí odkaz:
https://doaj.org/article/98ad82a33dce4f61bdbec3fadf8ac1a5
Autor:
Maša Vilfan, Urša Lampreht Tratar, Nina Milevoj, Alenka Nemec Svete, Maja Čemažar, Gregor Serša, Nataša Tozon
Publikováno v:
Animals, Vol 14, Iss 3, p 438 (2024)
Electrochemotherapy (ECT) in combination with the gene electrotransfer of interleukin 12 (IL-12 GET) has been successfully used in veterinary medicine for the treatment of mast cell tumours (MCT), but the biomarkers that could predict response to thi
Externí odkaz:
https://doaj.org/article/a951de04a55a4dc884c8f78c0ccc487f
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