A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling

Autor: Noémie Alphonse, Joseph J. Wanford, Andrew A. Voak, Jack Gay, Shayla Venkhaya, Owen Burroughs, Sanjana Mathew, Truelian Lee, Sasha L. Evans, Weiting Zhao, Kyle Frowde, Abrar Alrehaili, Ruth E. Dickenson, Mads Munk, Svetlana Panina, Ishraque F. Mahmood, Miriam Llorian, Megan L. Stanifer, Steeve Boulant, Martin W. Berchtold, Julien R.C. Bergeron, Andreas Wack, Cammie F. Lesser, Charlotte Odendall

Publikováno v: Alphonse, N, Wanford, J J, Voak, A A, Gay, J, Venkhaya, S, Burroughs, O, Mathew, S, Lee, T, Evans, S L, Zhao, W, Frowde, K, Alrehaili, A, Dickenson, R E, Munk, M, Panina, S, Mahmood, I F, Llorian, M, Stanifer, M L, Boulant, S, Berchtold, M W, Bergeron, J R C, Wack, A, Lesser, C F & Odendall, C 2022, ' A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling ', Cell, vol. 185, no. 13, pp. 2354-2369.e17 . https://doi.org/10.1016/j.cell.2022.04.028

Interferons (IFNs) induce an antimicrobial state, protecting tissues from infection. Many viruses inhibit IFN signaling, but whether bacterial pathogens evade IFN responses remains unclear. Here, we demonstrate that the Shigella OspC family of type-I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83dc8d786ef3ddcd48631cca6451b6f4
https://curis.ku.dk/ws/files/312499015/1_s2.0_S0092867422005268_main.pdf

An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation

Autor: Matteo Ferrari, Christian Krapp, Michela Muscolini, Angela Santoni, Martin R. Jakobsen, Alessandra Zevini, Alessandra Zingoni, David Olagnier, John Hiscott, Enrico Palermo, Giovanna Peruzzi, Luciano Castiello, Elisabetta Vulpis

Publikováno v: Castiello, L, Zevini, A, Vulpis, E, Muscolini, M, Ferrari, M, Palermo, E, Peruzzi, G, Krapp, C, Jakobsen, M, Olagnier, D, Zingoni, A, Santoni, A & Hiscott, J 2019, ' An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation ', Cancer Immunology, Immunotherapy, vol. 68, no. 9, pp. 1479-1492 . https://doi.org/10.1007/s00262-019-02380-2

RIG-I is a cytosolic RNA sensor that recognizes short 5 ' triphosphate RNA, commonly generated during virus infection. Upon activation, RIG-I initiates antiviral immunity, and in some circumstances, induces cell death. Because of this dual capacity,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a021b4cf5bcdbe0488874886620a2142
https://doi.org/10.1007/s00262-019-02380-2

An endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells

Autor: Connor G. G. Bamford, Conall McCaughey, Sheerien Manzoor, Lindsay Broadbent, Ultan F. Power, Ahlam A. Ali, David G. Courtney, Olivier Touzelet, Ken I. Mills, Guillermo Lopez Campos

Publikováno v: Broadbent, L, Bamford, C G G, Lopez Campos, G, Manzoor, S, Courtney, D, Ali, A, Touzelet, O, McCaughey, C, Mills, K & Power, U F 2022, ' An endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells ', PLoS ONE, vol. 17, no. 4, e0266412 . https://doi.org/10.1371/journal.pone.0266412

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the coronavirus disease-19 (COVID-19) pandemic, was identified in late 2019 and went on to cause over 3.3 million deaths in 15 months. To date, targeted antiviral intervention

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b124708d6f706c71a354a15eb2e0e064
https://doi.org/10.1371/journal.pone.0266412

ISG15 deficiency and increased viral resistance in humans but not mice

Autor: Zhi Li, Benhur Lee, Ilhan Tezcan, Payam Tabarsi, Sofija Buta, Nahal Mansouri, Frederic Vigant, Domenico Tortorella, James Duehr, Béatrice Payelle-Brogard, Sandra Pellegrini, Li Qian, Scott D. Speer, Véronique Francois-Newton, Davood Mansouri, Jacob Piehler, Alexander N. Freiberg, Mark Hermann, Thomas J. Gardner, Marisela R. Rodriguez, Ozden Sanal, Tim Wedeking, Adolfo García-Sastre, Coralie F. Daussy, Deborah J. Lenschow, Erminia Rubino, Dusan Bogunovic

Publikováno v: Nature communications, vol. 7, pp. 11496
Nature Communications
Nature Communications, Nature Publishing Group, 2016, 7, pp.11496. ⟨10.1038/ncomms11496⟩
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications, 2016, 7, pp.11496. ⟨10.1038/ncomms11496⟩

ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein. It exists as a free molecule, intracellularly and extracellularly, and conjugated to target proteins. Studies in mice have demonstrated a role for Isg15 in antiviral immunity. By cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e5d1fd4382cc5fb25eff02fa341fa9
https://serval.unil.ch/resource/serval:BIB_8158D3B3AE00.P001/REF.pdf

Distinct Clinical Phenotypes Associated with JAK2V617F Reflect Differential STAT1 Signaling

Autor: Emmanouil T. Dermitzakis, Peter J. Campbell, Anthony R. Green, Christina A. Ortmann, Edwin Chen, Anna L. Godfrey, Juan Li, Ana P. Costa-Pereira, Philip A. Beer, Catherine E. Ingle

Publikováno v: Cancer Cell, Vol. 18, No 5 (2010) pp. 524-535

SummaryThe JAK2V617F mutation is associated with distinct myeloproliferative neoplasms, including polycythemia vera (PV) and essential thrombocythemia (ET), but it remains unclear how it generates disparate disorders. By comparing clonally-derived mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bc7009547941792ed8350e777b1c47
https://doi.org/10.1016/j.ccr.2010.10.013