Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium

Autor: Caroline Trang, Salima Hacein-Bey Abina, Malin Ryner, Florian Deisenhammer, Manuel Comabella, Abiba Doukani, Philippe Broët, Anna Fogdell-Hahn, Julianne Duhaze, Hans-Peter Hartung, Clemens Warnke, Natacha Szely, Delphine Bachelet, Alessandra Vultaggio, Bernd C. Kieseier, Sebastian Spindeldreher, Olivier Brocq, Poul Erik Hyldgaard-Jensen, Michael Auer, Marc Pallardy, Matthieu Allez, Mary Birchler, Tom W J Huizinga, Yehuda Chowers, Yoram Bouhnik, Dorothea Buck-Martin, Elizabeth C. Jury, Amy Loercher, Dan Sikkema, Aude Gleizes, Tobias Derfuss, Jessica J Manson, Guillaume Cadiot, Claudia Sievers, Michael Khalil, Naoimh Donnellan, Raija L.P. Lindberg, Agnès Hincelin Mery, Badreddine Mohand Oumoussa, Enrico Maggi, Martin Soubrier, Kathleen Ingenhoven, Orhan Aktas, Sophie Tourdot, Xavier Montalban, Maria Nachury, Niek de Vries, Timothy P. Hickling, Christophe Richez, Bernhard Hemmer, Franck Carbonnel, Finn Sellebjerg, Jérôme Avouac, Petra Nytrova, Xavier Mariette, Anna Lauren, Signe Hässler, Pierre Dönnes, Eva Havrdova, Michael Guger, Claudia Mauri

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
PLoS Medicine
PLoS Medicine, 17(10). PUBLIC LIBRARY SCIENCE
PLoS Medicine, 2020, 17 (10), pp.e1003348. ⟨10.1371/journal.pmed.1003348⟩
Hässler, S, Bachelet, D, Duhaze, J, Szely, N, Gleizes, A, Hacein-Bey Abina, S, Aktas, O, Auer, M, Avouac, J, Birchler, M, Bouhnik, Y, Brocq, O, Buck-Martin, D, Cadiot, G, Carbonnel, F, Chowers, Y, Comabella, M, Derfuss, T, De Vries, N, Donnellan, N, Doukani, A, Guger, M, Hartung, H-P, Kubala Havrdova, E, Hemmer, B, Huizinga, T, Ingenhoven, K, Hyldgaard-Jensen, P E, Jury, E C, Khalil, M, Kieseier, B, Laurén, A, Lindberg, R, Loercher, A, Maggi, E, Manson, J, Mauri, C, Mohand Oumoussa, B, Montalban, X, Nachury, M, Nytrova, P, Richez, C, Ryner, M, Sellebjerg, F, Sievers, C, Sikkema, D, Soubrier, M, Tourdot, S, Trang, C, Vultaggio, A & ABIRISK Consortium 2020, ' Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease : A prospective multicohort study of the ABIRISK consortium ', PLoS Medicine, vol. 17, no. 10, e1003348 . https://doi.org/10.1371/journal.pmed.1003348
PLoS Medicine, Public Library of Science, 2020, 17 (10), pp.e1003348. ⟨10.1371/journal.pmed.1003348⟩
PLoS Medicine, Vol 17, Iss 10, p e1003348 (2020)
PLoS medicine, 17(10):e1003348. Public Library of Science

Background Biopharmaceutical products (BPs) are widely used to treat autoimmune diseases, but immunogenicity limits their efficacy for an important proportion of patients. Our knowledge of patient-related factors influencing the occurrence of antidru

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https://doi.org/10.1371/journal.pmed.1003348