Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs

Autor: Sonja I. Gringhuis, Tanja M. Kaptein, Ester B. M. Remmerswaal, Agata Drewniak, Brigitte A. Wevers, Bart Theelen, Geert R. A. M. D’Haens, Teun Boekhout, Teunis B. H. Geijtenbeek

Publikováno v: Nature Immunology, 23(12), 1735-1748. Nature Publishing Group
Nature immunology, 23(12), 1735-1748. Nature Publishing Group

The non-pathogenic TH17 subset of helper T cells clears fungal infections, whereas pathogenic TH17 cells cause inflammation and tissue damage; however, the mechanisms controlling these distinct responses remain unclear. Here we found that fungi sensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb95b9e0a1be7f25f872ff5b9849bad7
https://pure.knaw.nl/portal/en/publications/02768b71-10f2-4c54-9daa-117c4aec0199

The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection

Autor: Jean-Luc Davignon, Karima Naciri, Rabie Chelbi, Gilles Bessou, Chuang Dong, Nils Collinet, Michael Valente, Geoffray Brelurut, Pierre Milpied, Abdenour Abbas, Morgane Thomas-Chollier, Noudjoud Attaf, Thien-Phong Vu Manh, Inaki Cervera-Marzal, Alexandra-Chloé Villani, Benjamin Rauwel, Denis Thieffry, Marc Dalod, Elena Tomasello

Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2020, 21 (9), pp.983-997. ⟨10.1038/s41590-020-0731-4⟩
Nature Immunology, 2020, 21 (9), pp.983-997. ⟨10.1038/s41590-020-0731-4⟩
Nature immunology

International audience; Plasmacytoid dendritic cells (pDCs) are a major source of type I interferon (IFN-I). What other functions pDCs exert in vivo during viral infections is controversial, and more studies are needed to understand their orchestrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd76519d3ec2c2f1de126656bc2665f9
https://hal.archives-ouvertes.fr/hal-02980944/file/2020_11_30_Abbas_et_al_2020_accepted_manuscript_for_HAL_small_size.pdf

Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis

Autor: Iker Valle Aramburu, Margarida Saraiva, Anne O'Garra, Marianna Ioannou, Lúcia Moreira-Teixeira, Evangelos Stavropoulos, Qian Wang, Alejandro Suárez-Bonnet, Philippa J. Stimpson, Venizelos Papayannopoulos, Cristina Vilaplana, Kaori L. Fonseca, Probir Chakravarty, Eleanor Herbert, Paula Rodríguez-Martínez, Simon L. Priestnall, Sabelo Hadebe, Sergo Vashakidze, Jeremy Sousa

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Transcriptional signatures associated with type I IFN signalling and neutrophilic inflammation were shown to cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407353cfe6961f4fce97947d1ddae0cc
https://hdl.handle.net/10216/143506

The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection

Autor: Stempel, Markus, Chan, Baca, Juranić Lisnić, Vanda, Krmpotić, Astrid, Hartung, Josephine, Paludan, Søren R., Füllbrunn, Nadia, Lemmermann, Niels A.W., Brinkmann, Melanie M.

Publikováno v: The EMBO journal
Stempel, M, Chan, B, Juranić Lisnić, V, Krmpotić, A, Hartung, J, Paludan, S R, Füllbrunn, N, Lemmermann, N A W & Brinkmann, M M 2019, ' The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection ', EMBO Journal, vol. 38, no. 5, e100983 . https://doi.org/10.15252/embj.2018100983

Cytomegaloviruses (CMVs) are master manipulators of the host immune response. Here, we reveal that the murine CMV (MCMV) protein m152 specifically targets the type I interferon (IFN) response by binding to stimulator of interferon genes (STING), ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7fa460c44afcc5493733338e6428a20c
https://hdl.handle.net/10033/621687

An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication

Autor: Fulvio Reggiori, Jennifer Jung, Sharon A. Tooze, Søren R. Paludan, Mario Mauthe, Bjoern Stork, Cornelis A. M. de Haan, Martijn A. Langereis, Dave Egan, Frank J. M. van Kuppeveld, Alex Jones, Wienand A. Omta, Tero Ahola, Michal Mokry, Xingdong Zhou, Christian Behrends

Publikováno v: The Journal of Cell Biology, 214(5), 619-635. ROCKEFELLER UNIV PRESS
Journal of Cell Biology, 214(5), 619. Rockefeller University Press
Mauthe, M, Langereis, M, Jung, J, Zhou, X, Jones, A, Omta, W, Tooze, S A, Stork, B, Paludan, S R, Ahola, T, Egan, D, Behrends, C, Mokry, M, de Haan, C, van Kuppeveld, F & Reggiori, F 2016, ' An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication ', The Journal of Cell Biology, vol. 214, no. 5, pp. 619-35 . https://doi.org/10.1083/jcb.201602046
The Journal of Cell Biology
Journal of Cell Biology

Autophagy-related (ATG) proteins regulate autophagy, but recent work indicates that some also have autophagy-independent roles. Here, Mauthe et al. perform an unbiased siRNA screen to examine the effects of ATG protein depletion on viral replication

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93ac14c22a89d8f3e1b5bd144672d42
https://hdl.handle.net/11370/789dd442-58a8-4019-bfc0-6ad8a67485f0