Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Interferon Type I/genetics"'
Autor:
Christopher J.A. Duncan, Morten K. Skouboe, Sophie Howarth, Anne K. Hollensen, Rui Chen, Malene L. Børresen, Benjamin J. Thompson, Jarmila Stremenova Spegarova, Catherine F. Hatton, Frederik F. Stæger, Mette K. Andersen, John Whittaker, Søren R. Paludan, Sofie E. Jørgensen, Martin K. Thomsen, Jacob G. Mikkelsen, Carsten Heilmann, Daniela Buhas, Nina F. Øbro, Jakob T. Bay, Hanne V. Marquart, M. Teresa de la Morena, Joseph A. Klejka, Matthew Hirschfeld, Line Borgwardt, Isabel Forss, Tania Masmas, Anja Poulsen, Francisco Noya, Guy Rouleau, Torben Hansen, Sirui Zhou, Anders Albrechtsen, Reza Alizadehfar, Eric J. Allenspach, Sophie Hambleton, Trine H. Mogensen
Publikováno v:
Duncan, C J A, Skouboe, M K, Howarth, S, Hollensen, A K, Chen, R, Børresen, M L, Thompson, B J, Spegarova, J S, Hatton, C F, Stæger, F F, Andersen, M K, Whittaker, J, Paludan, S R, Jørgensen, S E, Thomsen, M K, Mikkelsen, J G, Heilmann, C, Buhas, D, Øbro, N F, Bay, J T, Marquart, H V, Morena, M T D L, Klejka, J A, Hirschfeld, M, Borgwardt, L, Forss, I, Masmas, T, Poulsen, A, Noya, F, Rouleau, G, Hansen, T, Zhou, S, Albrechtsen, A, Alizadehfar, R, Allenspach, E J, Hambleton, S & Mogensen, T H 2022, ' Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic ', Journal of Experimental Medicine, vol. 219, no. 6, e20212427 . https://doi.org/10.1084/jem.20212427
Duncan, C J A, Skouboe, M K, Howarth, S, Hollensen, A K, Chen, R, Børresen, M L, Thompson, B J, Stremenova Spegarova, J, Hatton, C F, Stæger, F F, Andersen, M K, Whittaker, J, Paludan, S R, Jørgensen, S E, Thomsen, M K, Mikkelsen, J G, Heilmann, C, Buhas, D, Øbro, N F, Bay, J T, Marquart, H V, de la Morena, M T, Klejka, J A, Hirschfeld, M, Borgwardt, L, Forss, I, Masmas, T, Poulsen, A, Noya, F, Rouleau, G, Hansen, T, Zhou, S, Albrechtsen, A, Alizadehfar, R, Allenspach, E J, Hambleton, S & Mogensen, T H 2022, ' Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic ', The Journal of Experimental Medicine, vol. 219, no. 6, e20212427 . https://doi.org/10.1084/jem.20212427
Duncan, C J A, Skouboe, M K, Howarth, S, Hollensen, A K, Chen, R, Børresen, M L, Thompson, B J, Stremenova Spegarova, J, Hatton, C F, Stæger, F F, Andersen, M K, Whittaker, J, Paludan, S R, Jørgensen, S E, Thomsen, M K, Mikkelsen, J G, Heilmann, C, Buhas, D, Øbro, N F, Bay, J T, Marquart, H V, de la Morena, M T, Klejka, J A, Hirschfeld, M, Borgwardt, L, Forss, I, Masmas, T, Poulsen, A, Noya, F, Rouleau, G, Hansen, T, Zhou, S, Albrechtsen, A, Alizadehfar, R, Allenspach, E J, Hambleton, S & Mogensen, T H 2022, ' Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic ', The Journal of Experimental Medicine, vol. 219, no. 6, e20212427 . https://doi.org/10.1084/jem.20212427
Type I interferons (IFN-I) play a critical role in human antiviral immunity, as demonstrated by the exceptionally rare deleterious variants of IFNAR1 or IFNAR2. We investigated five children from Greenland, Canada, and Alaska presenting with viral di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0e93df69405efb9dfa8932bb4d0da2
https://curis.ku.dk/portal/da/publications/lifethreatening-viral-disease-in-a-novel-form-of-autosomal-recessive-ifnar2-deficiency-in-the-arctic(38e5d906-7ed0-4521-981d-02d7dbdab48d).html
https://curis.ku.dk/portal/da/publications/lifethreatening-viral-disease-in-a-novel-form-of-autosomal-recessive-ifnar2-deficiency-in-the-arctic(38e5d906-7ed0-4521-981d-02d7dbdab48d).html
Autor:
Giulia Gallo, Elias Bendl, Florian Binder, Myriam Ermonval, Christine Luttermann, Rainer G. Ulrich, Isabella Eckerle
Publikováno v:
Archives of Virology, Vol. 166, No 11 (2021) pp. 2999-3012
Archives of Virology
Archives of Virology
The orthohantavirus Puumala virus (PUUV), which is transmitted by bank voles (Clethrionomys glareolus), and other vole-borne hantaviruses contain in their small (S) genome segment two overlapping open reading frames, coding for the nucleocapsid prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfcdaa6779e536e76d895bc65b6fc78
https://archive-ouverte.unige.ch/unige:157928
https://archive-ouverte.unige.ch/unige:157928
Autor:
Iker Valle Aramburu, Margarida Saraiva, Anne O'Garra, Marianna Ioannou, Lúcia Moreira-Teixeira, Evangelos Stavropoulos, Qian Wang, Alejandro Suárez-Bonnet, Philippa J. Stimpson, Venizelos Papayannopoulos, Cristina Vilaplana, Kaori L. Fonseca, Probir Chakravarty, Eleanor Herbert, Paula Rodríguez-Martínez, Simon L. Priestnall, Sabelo Hadebe, Sergo Vashakidze, Jeremy Sousa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Transcriptional signatures associated with type I IFN signalling and neutrophilic inflammation were shown to cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407353cfe6961f4fce97947d1ddae0cc
https://hdl.handle.net/10216/143506
https://hdl.handle.net/10216/143506
Autor:
Alexander A. Navarini, Curdin Conrad, Alessio Mylonas, Anne-Karine Lapointe, Jeremy Di Domizio, Olivier Demaria, Michel Gilliet, Cyrine Belkhodja, Lars E. French, Maxime Vernez
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature communications, vol. 9, no. 1, pp. 25
Nature Communications
Nature communications, vol. 9, no. 1, pp. 25
Although anti-tumor necrosis factor (TNF) agents are highly effective in the treatment of psoriasis, 2–5% of treated patients develop psoriasis-like skin lesions called paradoxical psoriasis. The pathogenesis of this side effect and its distinction
Autor:
Charlotte Möller, Gregory J. Buchan, Francisco J. Schopfer, Rachel E. Rigby, Hiroyuki Arai, Jonathan J. Miner, Wei Qian, Anne L. Thielke, Camilla Gunderstofte, Martin R. Jakobsen, Jan Rehwinkel, Jessica Roos, Mona Motwani, Sonia R. Salvatore, Katherine A. Fitzgerald, Marie B. Iversen, Rongtuan Lin, Raphaela Goldbach-Mansky, Christian K. Holm, Michael Rühl, Kojiro Mukai, Thorsten J. Maier, Tomohiko Taguchi, Cathrine A. Miner, Andreas S. Jakobsen, Anne-Louise S. Hansen, Emari Ogawa, David Olagnier, Sidsel D. Andersen
Publikováno v:
Hansen, A L, Buchan, G J, Rühl, M, Mukai, K, Salvatore, S R, Ogawa, E, Andersen, S D, Iversen, M B, Thielke, A L, Gunderstofte, C, Motwani, M, Møller, C T, Jakobsen, A S, Fitzgerald, K A, Roos, J, Lin, R, Maier, T J, Goldbach-Mansky, R, Miner, C A, Qian, W, Miner, J J, Rigby, R E, Rehwinkel, J, Jakobsen, M R, Arai, H, Taguchi, T, Schopfer, F J, Olagnier, D & Holm, C K 2018, ' Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 33, pp. E7768-E7775 . https://doi.org/10.1073/pnas.1806239115
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Several chronic inflammatory conditions have recently been shown to depend on abnormally high activity of the signaling protein stimulator of IFN genes (STING). These conditions include examples from systemic lupus erythematosus, Aicardi
Autor:
Christian Krapp, Jens von Einem, Marisa Gariglio, Sara Pautasso, Valentina Dell'Oste, Francesca Gugliesi, Santo Landolfo, Martin R. Jakobsen, Matteo Biolatti, Cinzia Borgogna, Marco De Andrea
Publikováno v:
Biolatti, M, Dell'Oste, V, Pautasso, S, Gugliesi, F, von Einem, J, Krapp, C, Jakobsen, M R, Borgogna, C, Gariglio, M, De Andrea, M & Landolfo, S 2018, ' Human cytomegalovirus tegument protein pp65 (pUL83) dampens type I interferon production by inactivating the DNA sensor cGAS without affecting STING ', Journal of Virology, vol. 92, no. 6, e01774-17 . https://doi.org/10.1128/JVI.01774-17
The innate immune response plays a pivotal role during human cytomegalovirus (HCMV) primary infection. Indeed, HCMV infection of primary fibroblasts rapidly triggers strong induction of type I interferons (IFN-I), accompanied by proinflammatory cytok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dfe9f54707f7fe560255620c1c97d7
https://pure.au.dk/portal/da/publications/human-cytomegalovirus-tegument-protein-pp65-pul83-dampens-type-i-interferon-production-by-inactivating-the-dna-sensor-cgas-without-affecting-sting(63238203-e4d3-4976-963e-343095a20474).html
https://pure.au.dk/portal/da/publications/human-cytomegalovirus-tegument-protein-pp65-pul83-dampens-type-i-interferon-production-by-inactivating-the-dna-sensor-cgas-without-affecting-sting(63238203-e4d3-4976-963e-343095a20474).html
Autor:
Adam Shlien, Denis Larsimont, Martine Piccart, Marc Abramowicz, Naima Kheddoumi, David Gacquer, Debora Fumagalli, Karen Willard-Gallo, David N Brown, Christine Desmedt, Tomasz Konopka, Vincent Detours, Anne Lefort, Kornelia Polyak, Frédérick Libert, Françoise Rothé, Christos Sotiriou, Peter J. Campbell, Roberto Salgado
Publikováno v:
Cell Reports, Vol 13, Iss 2, Pp 277-289 (2015)
Cell Reports
Cell reports
Cell Reports
Cell reports
Summary Little is known about how RNA editing operates in cancer. Transcriptome analysis of 68 normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly, on the same loci, across tissues. In controlled ADAR expression e
Autor:
Daniel T. Utzschneider, Mary-Anne Hartley, Matteo Rossi, Stephen M. Beverley, Remzi Onur Eren, Catherine Ronet, Florence Prevel, Maria Grazia Cusi, Patrik Castiglioni, Nicolas Fasel, F. Matthew Kuhlmann, Dietmar Zehn, Chantal Desponds
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 19, pp. 4987-4992
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
The presence of the endogenous Leishmania RNA virus 1 (LRV1) replicating stably within some parasite species has been associated with the development of more severe forms of leishmaniasis and relapses after drug treatment in humans. Here, we show tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c51b8002599b4fccbc5c3e303031b45
http://hdl.handle.net/11365/1006794
http://hdl.handle.net/11365/1006794
Publikováno v:
Pediatric rheumatology online journal, vol. 14, no. 1, pp. 35
Defective regulation of type I interferon response is associated with severe inflammatory phenotypes and autoimmunity. Type I interferonopathies are a clinically heterogenic group of Mendelian diseases with a constitutive activation of this pathway t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1900::6259d649ae88c66ae8976fb1d7306c11
https://serval.unil.ch/notice/serval:BIB_F53B15A22E70
https://serval.unil.ch/notice/serval:BIB_F53B15A22E70
Autor:
Christophe Desmet, Matthew L. Albert, Peter Staeheli, Andreas Wack, Sophia Davidson, Matthew R. Buckwalter, Tanel Mahlakõiv, Stefania Crotta
Publikováno v:
PLoS Pathogens
PLoS Pathogens, 2013, 9 (11), pp.e1003773. ⟨10.1371/journal.ppat.1003773⟩
PLoS Pathogens, Public Library of Science, 2013, 9 (11), pp.e1003773. ⟨10.1371/journal.ppat.1003773⟩
PLoS Pathogens, Vol 9, Iss 11, p e1003773 (2013)
PLoS Pathogens, 2013, 9 (11), pp.e1003773. ⟨10.1371/journal.ppat.1003773⟩
PLoS Pathogens, Public Library of Science, 2013, 9 (11), pp.e1003773. ⟨10.1371/journal.ppat.1003773⟩
PLoS Pathogens, Vol 9, Iss 11, p e1003773 (2013)
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to specific receptors on the same or neighbouring cells to activate the expression of hundreds of IF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0035bb1c07342ebc02c129d14a5a0b91
https://hal-pasteur.archives-ouvertes.fr/pasteur-01402018
https://hal-pasteur.archives-ouvertes.fr/pasteur-01402018