Zobrazeno 1 - 10
of 1 037
pro vyhledávání: '"Interferon (IFN)"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type I interferons (IFN-Is) are important players in the immunopathogenesis of systemic lupus erythematosus (SLE). Pathogenic events in patients with SLE are potent triggers of IFN-I induction, yet IFN-I may induce or initiate the immunopathogenesis
Externí odkaz:
https://doaj.org/article/d1d1a728913e40a7bf41c62bee4a192c
Autor:
Yumeng Li, Asha Ashuo, Menghan Hao, Yaming Li, Jianyu Ye, Jiangxia Liu, Ting Hua, Zhong Fang, Jianhua Li, Zhenghong Yuan, Jieliang Chen
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTType I interferons (IFN-Is) have key roles in immune defense and treatments for various diseases, including chronic hepatitis B virus (HBV) infection. All IFN-Is signal through a shared IFN-I heterodimeric receptor complex comprising IFN-α r
Externí odkaz:
https://doaj.org/article/584245a197254b2f9841523b625f2f65
Autor:
Jin Li, Zhuxia Jia, Rongxuan Wang, Bitao Xiao, Yanan Cai, Tianshu Zhu, Weiya Wang, Xinyue Zhang, Shu Fan, Xiaolong Fan, Wenmin Han, Xuzhang Lu
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionMultiple myeloma (MM) is a malignant plasma cell disease caused by abnormal proliferation of clonal plasma cells in bone marrow. Upfront identification of tumor subgroups with specific biological markers has the potential to improve biolo
Externí odkaz:
https://doaj.org/article/b3aa122c34cd41649136981fcedd7ee0
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type I interferons play a fundamental role in innate host defense against viral infections by eliciting the induction of an antiviral gene program that serves to inhibit viral replication. Activation of type I interferon is regulated by the IRF3 tran
Externí odkaz:
https://doaj.org/article/091f7621aef74cb8b10d86a618e78c08
Autor:
Anna Mennella, Katia Stefanantoni, Raffaella Palazzo, Giuseppe Ocone, Immacolata Pietraforte, Simona Truglia, Ilaria Bisconti, Alba Pisacreta, Valeria Riccieri, Roberto Lande, Loredana Frasca
Publikováno v:
Reports, Vol 7, Iss 3, p 66 (2024)
Background: Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular and immunity alterations and skin/internal organ fibrosis. Aberrant levels of plasma CXCL4, CXCL4–RNA/DNA complexes, type I IFN (IFN-I) and anti-CXCL4 antibodie
Externí odkaz:
https://doaj.org/article/f140cd011037435a8c6091acb4374b8c
Autor:
Szabina Erdő-Bonyár, Judit Rapp, Rovéna Subicz, Kristóf Filipánits, Tünde Minier, Gábor Kumánovics, László Czirják, Tímea Berki, Diána Simon
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7933 (2024)
Type I interferon (IFN-I) signaling has been shown to be upregulated in systemic sclerosis (SSc). Dysregulated B-cell functions, including antigen presentation, as well as antibody and cytokine production, all of which may be affected by IFN-I signal
Externí odkaz:
https://doaj.org/article/e218d4bc75444d0eac43d858e4c04cc3
Autor:
Victor M. Corman, Corinna Preusse, Julia Melchert, Olivier Benveniste, Randi Koll, Hans-Hilmar Goebel, Terry C. Jones, Christian Drosten, Ulrike Schara-Schmidt, Sarah Leonard-Louis, Werner Stenzel, Josefine Radke
Publikováno v:
Free Neuropathology, Vol 5 (2024)
Objective: To explore a possible connection between active viral infections and manifestation of Dermatomyositis (DM). Methods: Skeletal muscle biopsies were analyzed from patients diagnosed with juvenile (n=10) and adult (n=12) DM. Adult DM patien
Externí odkaz:
https://doaj.org/article/cba96a55687a4622b4a6a60b996ae40b
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Hepatitis B, a global health concern caused by the hepatitis B virus (HBV), infects nearly 2 billion individuals worldwide, as reported by the World Health Organization (WHO). HBV, a hepatotropic DNA virus, predominantly targets and replicates within
Externí odkaz:
https://doaj.org/article/d7591a6715244a10b4ef447c2db73ea5
Autor:
Léa Meyer, Isoline Duquénois, Stacy Gellenoncourt, Marie Pellerin, Aïlona Marcadet-Hauss, Nicole Pavio, Virginie Doceul
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHepatitis E virus (HEV) is a common cause of enterically transmitted acute hepatitis worldwide. The virus is transmitted by the fecal-oral route via the consumption of contaminated water supplies and is also a zoonotic foodborne pathogen.
Externí odkaz:
https://doaj.org/article/7d69c5eca08d4a7497b8eef90c8e1a5e
Autor:
Anna Zaninoni, Bruno Fattizzo, Loredana Pettine, Cristina Vercellati, Anna P. Marcello, Wilma Barcellini
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Autoimmune hemolytic anemia (AIHA) is due to autoantibodies with or without complement activation and involves cellular and cytokine dysregulation. Here, we investigated cytokine single-nucleotide polymorphisms (SNPs) of TNF-α, TGF-β1, IL-10, IL-6,
Externí odkaz:
https://doaj.org/article/0067351f118c44ec88bea0250cfa7556