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pro vyhledávání: '"Integrin Signaling"'
Akademický článek
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Autor:
Min Chen, Brock Marrs, Lei Qi, Teresa Knifley, Heidi L. Weiss, John A. D’Orazio, Kathleen L. O’Connor
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Integrin α6β4 is highly expressed in triple negative breast cancer (TNBC) and drives its most aggressive traits; however, its impact on chemotherapeutic efficacy remains untested. We found that integrin α6β4 signaling promoted sensitivity to cisp
Externí odkaz:
https://doaj.org/article/9bf333782f3b45e787d3bccde326be3f
Autor:
Uddalak Majumdar, Talita Z. Choudhury, Sathiyanarayanan Manivannan, Yukie Ueyama, Madhumita Basu, Vidu Garg
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Calcific aortic valve disease (CAVD) is an increasingly prevalent condition among the elderly population that is associated with significant morbidity and mortality. Insufficient understanding of the underlying disease mechanisms has hindered the dev
Externí odkaz:
https://doaj.org/article/8db773e75a59473ebe8022861c469e6c
Autor:
Romana Dolinschek, Julia Hingerl, Anke Benge, Christian Zafiu, Elisabeth Schüren, Eva‐Kathrin Ehmoser, Daniela Lössner, Ute Reuning
Publikováno v:
Molecular Oncology, Vol 15, Iss 2, Pp 503-522 (2021)
Epithelial ovarian cancer involves the shedding of single tumor cells or spheroids from the primary tumor into ascites, followed by their survival, and transit to the sites of metastatic colonization within the peritoneal cavity. During their flotati
Externí odkaz:
https://doaj.org/article/a58f4369c3d643f787594f02068e8af1
Autor:
Usman Yaqoob, Fanghong Luo, Thomas Greuter, Nidhi Jalan Sakrikar, Tejasav S. Sehrawat, Jianwen Lu, Xiao Hu, Jinhang Gao, Enis Kostallari, Jingbiao Chen, Juan Pablo Arab, Rosa Martin-Mateos, Sheng Cao, Vijay H. Shah
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 545-559 (2020)
Background & Aims: Transforming growth factor (TGF-β)–induced activation of quiescent hepatic stellate cells (HSCs) and their transformation to myofibroblasts is a key event in liver fibrosis and portal hypertension. GIPC (also referred to as syne
Externí odkaz:
https://doaj.org/article/f495be7a054c46fdb9e1cfcbdd2f7250
Autor:
Alan C. Rapraeger
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Receptor tyrosine kinases (RTKs) and integrin matrix receptors have well-established roles in tumor cell proliferation, invasion and survival, often functioning in a coordinated fashion at sites of cell-matrix adhesion. Central to this coordination a
Externí odkaz:
https://doaj.org/article/c451e6ab641240dabb6ab835fa364640
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021)
Background Adhesion of vascular endothelial cells to the underlying basement membrane potently modulates endothelial cells to cells' inflammatory activation. The normal basement membrane proteins laminin and collagen IV attenuate inflammatory signali
Externí odkaz:
https://doaj.org/article/b9d7f4d104a34a08b1afa1ccf92c1123
Autor:
Nirdosh Dadwal, Charlie Mix, Annegret Reinhold, Amelie Witte, Christian Freund, Burkhart Schraven, Stefanie Kliche
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T cells are the key players of the adaptive immune response. They coordinate the activation of other immune cells and kill malignant and virus-infected cells. For full activation T cells require at least two signals. Signal 1 is induced after recogni
Externí odkaz:
https://doaj.org/article/83cf366000cf4fc7b63668138c2eceab
Autor:
Tamara Viscarra, Kurt Buchegger, Ignacio Jofre, Ismael Riquelme, Louise Zanella, Michel Abanto, Alyssa C. Parker, Stephen R. Piccolo, Juan Carlos Roa, Carmen Ili, Priscilla Brebi
Publikováno v:
Biological Research, Vol 52, Iss 1, Pp 1-13 (2019)
Abstract Background Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). However, CBDCA resistance is the main obstacle to a better prognosis. An in
Externí odkaz:
https://doaj.org/article/5b968cb14f094ad28b0adfe0083c92d5
Publikováno v:
Cells, Vol 11, Iss 13, p 2115 (2022)
Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix (ECM) protein belonging to the fibrinogen-related domain superfamily. MFAP4 is highly expressed in elastin-rich tissues such as lung, blood vessels and skin. MFAP4 is involved in
Externí odkaz:
https://doaj.org/article/5f3be132797a44e2ad1c04c7cb012517