Zobrazeno 1 - 10
of 1 126
pro vyhledávání: '"Integrative Genomics"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract The Ets domain transcription factors direct diverse biological processes throughout all metazoans and are implicated in development as well as in tumor initiation, progression and metastasis. The Drosophila Ets transcription factor Pointed (
Externí odkaz:
https://doaj.org/article/01ed04b415a2487381024ef050e95aea
Autor:
Yizhou Huang, Jie Luo, Yue Zhang, Tao Zhang, Xiangwei Fei, Liqing Chen, Yingfan Zhu, Songyue Li, Caiyun Zhou, Kaihong Xu, Yunlong Ma, Jun Lin, Jianhong Zhou
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1510-1522 (2023)
The risk of endometriosis (EM), which is a common complex gynaecological disease, is related to genetic predisposition. However, it is unclear how genetic variants confer the risk of EM. Here, via Sherlock integrative analysis, we combined large-scal
Externí odkaz:
https://doaj.org/article/5727e9a9499744ba84fa13ea4cc3627b
Akademický článek
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Publikováno v:
International Journal of Yoga, Vol 15, Iss 1, Pp 25-39 (2022)
Background: Yoga is a multifaceted spiritual tool that helps in maintaining health, peace of mind, and positive thoughts. In the context of asana, yoga is similar to physical exercise. This study aims to construct a molecular network to find hub gene
Externí odkaz:
https://doaj.org/article/74d4d864fa084c2c9dd075996e78b3a1
Autor:
Thomas J. Hall, Michael P. Mullen, Gillian P. McHugo, Kate E. Killick, Siobhán C. Ring, Donagh P. Berry, Carolina N. Correia, John A. Browne, Stephen V. Gordon, David E. MacHugh
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-20 (2021)
Abstract Background Bovine TB (bTB), caused by infection with Mycobacterium bovis, is a major endemic disease affecting global cattle production. The key innate immune cell that first encounters the pathogen is the alveolar macrophage, previously sho
Externí odkaz:
https://doaj.org/article/e6c8c3ca816f46c88509ae42931d90f0
Autor:
Yan Li, Xiaodong Pang, Zihan Cui, Yidong Zhou, Feng Mao, Yan Lin, Xiaohui Zhang, Songjie Shen, Peixin Zhu, Tingting Zhao, Qiang Sun, Jinfeng Zhang
Publikováno v:
Molecular Oncology, Vol 14, Iss 11, Pp 2775-2786 (2020)
It is well known that different racial groups have significantly different incidence and mortality rates for certain cancers. It has been suggested that biological factors play a major role in these cancer racial disparities. Previous studies on the
Externí odkaz:
https://doaj.org/article/cef1f0ece0fb49429bd5955dfc23cd2c
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-24 (2020)
Abstract To provide a comprehensive mechanistic interpretation of how known trait-associated SNPs affect complex traits, we propose a method, Primo, for integrative analysis of GWAS summary statistics with multiple sets of omics QTL summary statistic
Externí odkaz:
https://doaj.org/article/2dec3656a2734bdd8395c727ad44a4e5
Autor:
Hiroki Yagi, Hiroshi Takiguchi, Norifumi Takeda, Ryo Inuzuka, Yuki Taniguchi, Kristine Joyce Porto, Hiroyuki Ishiura, Jun Mitsui, Hiroyuki Morita, Issei Komuro
Publikováno v:
Clinical Case Reports, Vol 10, Iss 2, Pp n/a-n/a (2022)
Abstract Congenital contractural arachnodactyly (CCA) is caused by pathogenic FBN2 variants; however, the contributions of copy number variations (CNVs) to CCA are still unknown. Here, we report on a familial case of CCA, in which a novel multiexon d
Externí odkaz:
https://doaj.org/article/625ec588b80e40d9940d87d25c621beb
Akademický článek
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Autor:
Montgomery Blencowe, In Sook Ahn, Zara Saleem, Helen Luk, Ingrid Cely, Ville-Petteri Mäkinen, Yuqi Zhao, Xia Yang
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100019- (2021)
Genome-wide association studies (GWASs) have implicated ∼380 genetic loci for plasma lipid regulation. However, these loci only explain 17–27% of the trait variance, and a comprehensive understanding of the molecular mechanisms has not been achie
Externí odkaz:
https://doaj.org/article/8925d4bcac4e4372b2a791ddc2dfa754