Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Insulin-Secreting Cells/secretion"'
Autor:
Guay, C., Regazzi, R.
Publikováno v:
Diabetes, obesity & metabolism, vol. 19 Suppl 1, pp. 137-146
Blood glucose homeostasis requires a constant communication between insulin-secreting and insulin-sensitive cells. A wide variety of circulating factors, including hormones, cytokines and chemokines work together to orchestrate the systemic response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1900::c20028d14e9ebce5443336d9a20cc3b3
https://serval.unil.ch/notice/serval:BIB_67B77266C639
https://serval.unil.ch/notice/serval:BIB_67B77266C639
Autor:
Fiorenza Agosti, Alessandra De Col, Amalia Gastaldelli, Claudio Tiribelli, Giorgio Bedogni, Alessandro Sartorio, Rezene Fessehatsion
Publikováno v:
Journal of endocrinological investigation. 37(8)
Background Non-alcoholic fatty liver disease (NAFLD) is an independent predictor of type 2 diabetes mellitus (T2DM). Insulin resistance and beta-cell dysfunction are involved in the pathogenesis of T2DM. Insulin resistance is associated with NAFLD bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32992f0c6544ad769462ed96e491dbe
https://pubmed.ncbi.nlm.nih.gov/24906975
https://pubmed.ncbi.nlm.nih.gov/24906975
Autor:
Dorothée Caille, Romano Regazzi, E. Roggli, Sonia Gattesco, Christian Boitard, Paolo Meda, Claire Briet
Publikováno v:
Diabetes, vol. 61, no. 7, pp. 1742-1751
Diabetes
Diabetes
During the initial phases of type 1 diabetes, pancreatic islets are invaded by immune cells, exposing β-cells to proinflammatory cytokines. This unfavorable environment results in gene expression modifications leading to loss of β-cell functions. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d4c5e3ab7c6e1f9ec5e1c622a4a701
https://doi.org/10.2337/db11-1086
https://doi.org/10.2337/db11-1086
Autor:
Kenneth K.Y. Cheng, Gary Sweeney, Karen S.L. Lam, Yu Wang, Jialiang Zhang, Ruby L. C. Hoo, Donghai Wu, Aimin Xu
Publikováno v:
Proceedings of the National Academy of Sciences. 109:8919-8924
Insulin resistance and defective insulin secretion are the two major features of type 2 diabetes. The adapter protein APPL1 is an obligatory molecule in regulating peripheral insulin sensitivity, but its role in insulin secretion remains elusive. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a7deeb6860d311b1a43394c57dce49
https://doi.org/10.1073/pnas.1202435109
https://doi.org/10.1073/pnas.1202435109
Autor:
Charna Dibner, Ulrich Schibler
Publikováno v:
Science, Vol. 350, No 6261 (2015) pp. 628-9
SCIENCE
SCIENCE
The circadian timing system plays an essential role in the temporal coordination of metabolism in health and disease ( 1 ). This includes maintaining blood glucose homeostasis, a process that is regulated to a large extent by insulin. Cell-autonomous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314175027c6bef613a9b70a9acfebc55
https://doi.org/10.1126/science.aad5412
https://doi.org/10.1126/science.aad5412
Autor:
Cécile Jacovetti, Romano Regazzi
Publikováno v:
Cell Cycle
Cell Cycle, vol. 12, no. 2, pp. 197-198
Cell Cycle, vol. 12, no. 2, pp. 197-198
Pancreatic β-cells, located within the islets of Langerhans, are key players in the control of blood glucose homeostasis. The amount of insulin secreted by these cells is precisely adjusted to avoi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7988cccd163912b8cb3733ac7a61d6e
https://pubmed.ncbi.nlm.nih.gov/23287464
https://pubmed.ncbi.nlm.nih.gov/23287464
Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction
Autor:
Ning Li, Pierre Maechler, Miriam Cnop, Decio L. Eizirik, Daniel Andrade Da Cunha, Thierry Brun
Publikováno v:
Journal of Biological Chemistry, Vol. 284, No 35 (2009) pp. 23602-12
The Journal of biological chemistry, 284 (35
The Journal of biological chemistry, 284 (35
Transient exposure of beta-cells to oxidative stress interrupts the transduction of signals normally coupling glucose metabolism to insulin secretion. We investigated putative persistence of effects induced by one transient oxidative stress (200 micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f13eb74594c611fa76c0b9f5bc7a25b
https://archive-ouverte.unige.ch/unige:5657
https://archive-ouverte.unige.ch/unige:5657
Publikováno v:
Nature Communications
Nature Communications, vol. 6, pp. 8084
Nature Communications, vol. 6, pp. 8084
Glucose-induced insulin secretion is an essential function of pancreatic β-cells that is partially lost in individuals affected by Type 2 diabetes. This unique property of β-cells is acquired through a poorly understood postnatal maturation process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5354c8e23573614aff45446feb23a679
http://www.nature.com/ncomms/2015/150902/ncomms9084/full/ncomms9084.html
http://www.nature.com/ncomms/2015/150902/ncomms9084/full/ncomms9084.html