Výsledky vyhledávání - "Insulin-Secreting Cells/metabolism/secretion"

Hepatic glucose sensing is required to preserve β cell glucose competence

Autor: Seyer Pascal, Vallois David, Poitry-Yamate Carole, Schütz Frédéric, Metref Salima, Tarussio David, Maechler Pierre, Staels Bart, Lanz Bernard, Grueter Rolf, Decaris Julie, Turner Scott, Da Costa Anabela, Preitner Frédéric, Minehira Kaori, Foretz Marc, Thorens Bernard

Publikováno v: Journal of Clinical Investigation, Vol. 123, No 4 (2013) pp. 1662-76
Journal of Clinical Investigation, vol. 123, no. 4, pp. 1662-1676
Journal of Clinical Investigation

Liver glucose metabolism plays a central role in glucose homeostasis and may also regulate feeding and energy expenditure. Here we assessed the impact of glucose transporter 2 (Glut2) gene inactivation in adult mouse liver (LG2KO mice). Loss of Glut2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15358b3f631566e869bb768f4696dfe8
https://archive-ouverte.unige.ch/unige:28233

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Mitochondrial dysfunction in pancreatic β cells

Autor: Supale, Sachin, Li, Ning, Brun, Thierry, Maechler, Pierre

Publikováno v: Trends in Endocrinology and Metabolism, Vol. 23, No 9 (2012) pp. 477-87

In pancreatic β cells, mitochondria play a central role in coupling glucose metabolism to insulin exocytosis, thereby ensuring strict control of glucose-stimulated insulin secretion. Defects in mitochondrial function impair this metabolic coupling,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::b03f27c8effae67d297d3e4695f309ea
https://archive-ouverte.unige.ch/unige:28014

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Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells

Autor: Asllan Gjinovci, Jorge Tamarit-Rodriguez, Andreas Wiederkehr, Nicole Feldmann, Claes B. Wollheim, Rafael Martín del Río

Publikováno v: Molecular and Cellular Endocrinology, Vol. 338, No 1-2 (2011) pp. 46-57

Glutamate is generated during nutrient stimulation of pancreatic islets and has been proposed to act both as an intra- and extra-cellular messenger molecule. We demonstrate that glutamate is not co-secreted with the hormones from intact islets or pur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111c89eb7b5bd970ba93c7cbbe8daf75
https://pubmed.ncbi.nlm.nih.gov/21371522

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Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction

Autor: Ning Li, Pierre Maechler, Miriam Cnop, Decio L. Eizirik, Daniel Andrade Da Cunha, Thierry Brun

Publikováno v: Journal of Biological Chemistry, Vol. 284, No 35 (2009) pp. 23602-12
The Journal of biological chemistry, 284 (35

Transient exposure of beta-cells to oxidative stress interrupts the transduction of signals normally coupling glucose metabolism to insulin secretion. We investigated putative persistence of effects induced by one transient oxidative stress (200 micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f13eb74594c611fa76c0b9f5bc7a25b
https://archive-ouverte.unige.ch/unige:5657

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