Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Insulin-Secreting Cells/enzymology"'
Autor:
Pullen, Timothy J
Publikováno v:
Pullen, T J 2016, ' Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function ', CELL METABOLISM, vol. 23, no. 5, pp. 821-836 . https://doi.org/10.1016/j.cmet.2016.04.003
Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-activated protein kinase (AMPK) has been proposed as an attractive strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2761::ed306f67788d55bbbd3b2f700c76dc47
https://kclpure.kcl.ac.uk/en/publications/c8ed4994-76eb-4ba9-92fd-0f09f7019677
https://kclpure.kcl.ac.uk/en/publications/c8ed4994-76eb-4ba9-92fd-0f09f7019677
Publikováno v:
Traffic, vol. 11, no. 1, pp. 123-137
Traffic (Copenhagen Denmark)
Traffic, Vol. 11, No 1 (2010) pp. 123-137
Traffic (Copenhagen Denmark)
Traffic, Vol. 11, No 1 (2010) pp. 123-137
The role of PIP(2) in pancreatic beta cell function was examined here using the beta cell line MIN6B1. Blocking PIP(2) with PH-PLC-GFP or PIP5KIgamma RNAi did not impact on glucose-stimulated secretion although susceptibility to apoptosis was increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f39ff46dbbeb0d80d9a8f45fd0798a4
https://doi.org/10.1111/j.1600-0854.2009.00996.x
https://doi.org/10.1111/j.1600-0854.2009.00996.x
Autor:
Stefania Carobbio, Asllan Gjinovci, Laurene Marine Vetterli, Maria Bloksgaard, Francesca Frigerio, Blanca Rubi, Shirin Pournourmohammadi, Walter Reith, Pierre Maechler, Pedro Luis Herrera, Susanne Mandrup
Publikováno v:
Journal of Biological Chemistry, Vol. 284, No 2 (2009) pp. 921-929
Carobbio, S, Frigerio, F, Rubi, B, Vetterli, L, Mølgaard, M B, Gjinovci, A, Pournourmohammad, S, Herrera, P L, Reith, W, Mandrup, S & Maechler, P 2009, ' Deletion of Glutamate Dehydrogenase in ß-Cells Abolishes Part of the Insulin Secretory Response Not Required for Glucose Homeostasis ', Journal of Biological Chemistry, vol. 284, no. 2, pp. 921-929 . https://doi.org/10.1074/jbc.M806295200
Carobbio, S, Frigerio, F, Rubi, B, Vetterli, L, Mølgaard, M B, Gjinovci, A, Pournourmohammad, S, Herrera, P L, Reith, W, Mandrup, S & Maechler, P 2009, ' Deletion of Glutamate Dehydrogenase in ß-Cells Abolishes Part of the Insulin Secretory Response Not Required for Glucose Homeostasis ', Journal of Biological Chemistry, vol. 284, no. 2, pp. 921-929 . https://doi.org/10.1074/jbc.M806295200
Udgivelsesdato: 2009-Jan-9 Insulin exocytosis is regulated in pancreatic ss-cells by a cascade of intracellular signals translating glucose levels into corresponding secretory responses. The mitochondrial enzyme glutamate dehydrogenase (GDH) is regar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a781c6b0872609f0b079b477bd4c00
https://doi.org/10.1074/jbc.m806295200
https://doi.org/10.1074/jbc.m806295200
Autor:
Daniel Pipeleers, Chen Wang, Zhidong Ling, Åke Lernmark, Christiane S. Hampe, Frans Gorus, Mao Rui, Pieter De Pauw
Publikováno v:
Journal of immunological methods. 319(1-2)
The 65 kDa isoform of human glutamate decarboxylase (GAD65) is a major autoantigen in type 1 diabetes (T1D). In the present study, we have developed a sensitive sandwich time-resolved fluorescence immunoassay (TRFIA) for the quantification of GAD65 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd90ea5313b36a089fcd20e1aaf810e
https://pubmed.ncbi.nlm.nih.gov/17210161
https://pubmed.ncbi.nlm.nih.gov/17210161
Autor:
Michael P. Murtaugh, Kate R. Mueller, Christophe Bonny, Saida Abdelli, Bernhard J. Hering, Klearchos K. Papas
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 7, p e99796 (2014)
Plos One, vol. 9, no. 7, pp. e99796
PLoS ONE, Vol 9, Iss 7, p e99796 (2014)
Plos One, vol. 9, no. 7, pp. e99796
Stress conditions generated throughout pancreatic islet processing initiate the activation of pro-inflammatory pathways and beta-cell destruction. Our goal is to identify relevant and preferably beta-specific markers to assess the activation of beta-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4a9964a56def2f7b9080d150219e32
https://doi.org/10.1371/journal.pone.0099796
https://doi.org/10.1371/journal.pone.0099796