The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets

Autor: Dan Ploug Christensen, Jakob Bondo Hansen, Thomas Mandrup-Poulsen, Seyed Mojtaba Ghiasi, Björn Tyrberg

Publikováno v: International Journal of Molecular Sciences
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International journal of molecular sciences, vol. 21, no. 12 . https://doi.org/10.3390/ijms21124311
International Journal of Molecular Sciences, Vol 21, Iss 4311, p 4311 (2020)
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International Journal of Molecular Sciences (Online), vol. 21, no. 12, 4311 . https://doi.org/10.3390/ijms21124311
Volume 21
Issue 12

Background: Intercellular communication mediated by cationic fluxes through the Connexin family of gap junctions regulates glucose-stimulated insulin secretion and beta cell defense against inflammatory stress. Rotigaptide (RG, ZP123) is a peptide an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6abcd30245c0405a97103ff0148386
http://europepmc.org/articles/PMC7352593

Disruption of fasting and post-load glucose homeostasis are largely independent and sustained by distinct and early major beta-cell function defects: a cross-sectional and longitudinal analysis of the Relationship between Insulin Sensitivity and Cardiovascular risk (RISC) study cohort

Autor: Andrea Natali, Lorenzo Nesti, Andrea Mari, John R. Petrie, Asimina Mitrakou, Kurt Højlund, Domenico Tricò, Risc Investigators, Alessandro Mengozzi, Michael Krebs

Publikováno v: Mengozzi, A, Trico, D, Nesti, L, Petrie, J, Hojlund, K, Mitrakou, A, Krebs, M, Mari, A, Natali, A & Investigators, RISC 2020, ' Disruption of fasting and post-load glucose homeostasis are largely independent and sustained by distinct and earlymajor beta-cell function defects: a cross-sectional and longitudinal analysis of the Relationship between Insulin Sensitivity and Cardiovascular risk (RISC) study cohort ', Metabolism, vol. 105, 154185 . https://doi.org/10.1016/j.metabol.2020.154185

Background/aims: \ud Uncertainty still exists on the earliest beta-cell defects at the bases of the type 2 diabetes. We assume that this depends on the inaccurate distinction between fasting and post-load glucose homeostasis and aim at providing a de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e2330967e769c66f9ca31e6fdc3a56
https://doi.org/10.1016/j.metabol.2020.154185

Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment

Autor: Ruiz, L., Gurlo, T., Ravier, Ma, Anne Wojtusciszyn, Mathieu, J., Brown, MR, Broca, C., Bertrand, G., Butler, Pc, Matveyenko, Av, Dalle, S., Costes, S.

Publikováno v: Cell Death Discovery
Cell Death Discovery, Springer Nature, 2018, 9 (6), pp.600. ⟨10.1038/s41419-018-0603-0⟩
Cell death & disease, vol 9, iss 6
Cell Death & Disease
Cell Death Discovery, 2018, 9 (6), pp.600. ⟨10.1038/s41419-018-0603-0⟩
BASE-Bielefeld Academic Search Engine
Ruiz, L; Gurlo, T; Ravier, MA; Wojtusciszyn, A; Mathieu, J; Brown, MR; et al.(2018). Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. CELL DEATH & DISEASE, 9. doi: 10.1038/s41419-018-0603-0. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9894r9hv
Cell Death and Disease, Vol 9, Iss 6, Pp 1-12 (2018)
Cell Death Dis, vol. 9, no. 6, pp. 600

International audience; In type 2 diabetes, amyloid oligomers, chronic hyperglycemia, lipotoxicity, and pro-inflammatory cytokines are detrimental to beta-cells, causing apoptosis and impaired insulin secretion. The histone acetyl transferase p300, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::37b23853e8fe19449b6ad632d948a168
https://hal.archives-ouvertes.fr/hal-02320439/file/pdfjoiner.pdf

Glucagon-Like Peptide-1 Triggers Protective Pathways in Pancreatic Beta-Cells Exposed to Glycated Serum

Autor: François Mach, Roberta Sanguineti, Alessandra Puddu, Giorgio Luciano Viviani, Fabrizio Montecucco, Alessio Nencioni, Arianna Durante

Publikováno v: Mediators of Inflammation, Vol. 2013 (2013) P. 317120
Mediators of Inflammation
Mediators of Inflammation, Vol 2013 (2013)

Advanced glycation end products (AGEs) might play a pathophysiological role in the development of diabetes and its complications. AGEs negatively affect pancreatic beta-cell function and the expression of transcriptional factors regulating insulin ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e81936c2739939c2843eb8a253f1e9
https://doi.org/10.1155/2013/317120

Procyanidins modify insulinemia by affecting insulin production and degradation

Autor: Victor Pallarès, Santiago Garcia-Vallvé, Anna Ardévol, M. José Motilva, M. Teresa Blay, Pierre Maechler, Anna Castell-Auví, Lídia Cedó, Gerard Pujadas, Montserrat Pinent

Publikováno v: Journal of Nutritional Biochemistry, Vol. 23, No 12 (2012) pp. 1565-72
The Journal of nutritional biochemistry

Previous studies from our research group have suggested that procyanidins modify glycemia and insulinemia. The aim of this work was to evaluate the effects of procyanidins on β-cell functionality in a nonpathological system. Four groups of healthy r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a66716f5a5050e7df8d75cbb64b997f
https://doi.org/10.1016/j.jnutbio.2011.10.010