Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Insulin-Secreting Cells/cytology/*metabolism"'
Autor:
Karim Bouzakri, Katharina Rickenbach, Caroline Arous, Michel Pinget, Bernhard Wehrle-Haller, Maria L. Mizgier
Publikováno v:
Journal of Biological Chemistry, Vol. 295, No 49 (2020) pp. 16510-16528
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Elevated levels of fasting insulin release and insufficient glucose-stimulated insulin secretion (GSIS) are hallmarks of diabetes. Studies have established cross-talk between integrin signaling and insulin activity, but more details of how integrin-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4063a6b9e04781fc7fe5d6ec0c61ec14
https://doi.org/10.1074/jbc.ra120.012957
https://doi.org/10.1074/jbc.ra120.012957
Autor:
Fanny Lebreton, Sylvie Renaud, Romain Perrier, Stéphane Arbault, Jochen Lang, Antoine Pirog, Alexander Kuhn, Aleksandar Karajić, Matthieu Raoux, Julien Gaitan, Eileen Pedraza
Publikováno v:
Lab on a Chip
Lab on a Chip, Royal Society of Chemistry, 2015, 15, ⟨10.1039/C5LC00616C⟩
Lab on a Chip, Vol. 15, No 19 (2015) pp. 3880-3890
Lab on a Chip, Royal Society of Chemistry, 2015, 15, ⟨10.1039/C5LC00616C⟩
Lab on a Chip, Vol. 15, No 19 (2015) pp. 3880-3890
International audience; We are developing a cell-based bioelectronic glucose sensor that exploits the multi-parametric sensing ability of pancreatic islet cells for the treatment of diabetes. These cells sense changes in the concentration of glucose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589a1e3a341b7edfaf0c6bd142c86c6b
https://doi.org/10.1039/c5lc00616c
https://doi.org/10.1039/c5lc00616c
Autor:
Jaime Santo-Domingo, Andreas Wiederkehr, Gabriele Galliverti, Jeffrey A. Hubbell, Olivier Burri, Steinunn Baekkeskov, Lorenzo Piemonti, Chiara Cianciaruso, Edward A. Phelps, Ekaterine Berishvili, Miriella Pasquier
Publikováno v:
Scientific reports, vol 7, iss 1
Scientific Reports, Vol. 7 (2017) P. 45961
Scientific Reports, Vol. 7 (2017) P. 45961
A robust and reproducible method for culturing monolayers of adherent and well-spread primary islet cells on glass coverslips is required for detailed imaging studies by super-resolution and live-cell microscopy. Guided by an observation that dispers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb1f6f98ef2efea098cabd28c53a29d
https://escholarship.org/uc/item/629576cw
https://escholarship.org/uc/item/629576cw
Autor:
Philippe A. Halban, Dieter Rondas, Martinho Soto-Ribeiro, Bernhard Wehrle-Haller, Alejandra Tomas
Publikováno v:
The Journal of biological chemistry
Journal of Biological Chemistry, Vol. 287, No 4 (2012) pp. 2423-36
Journal of Biological Chemistry, Vol. 287, No 4 (2012) pp. 2423-36
Actin cytoskeleton remodeling is well known to be positively involved in glucose-stimulated pancreatic beta cell insulin secretion. We have observed glucose-stimulated focal adhesion remodeling at the beta cell surface and have shown this to be cruci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9fa1e8da4cac7dad1525b2144c3668
Autor:
Paolo Meda, Anne Charollais, Philippe Klee, Dorothée Caille, Jacques-Antoine Haefliger, Smaragda Lamprianou, Rossella Sarro, Manon Cederroth
Publikováno v:
Pediatric Research; Vol 70
Pediatric Research, Vol. 70, No 2 (2011) pp. 142-7
Pediatric research
Pediatric Research
Pediatric Research, Vol. 70, No 2 (2011) pp. 142-7
Pediatric research
Pediatric Research
Diabetes develops when the insulin needs of peripheral cells exceed the availability or action of the hormone. This situation results from the death of most beta-cells in type 1 diabetes, and from an inability of the beta-cell mass to adapt to increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eec4cf7b3163d97ce59a4e621342825
https://doi.org/10.1203/pdr.0b013e318220f106
https://doi.org/10.1203/pdr.0b013e318220f106
Autor:
Asllan Gjinovci, Carmen M. Jimenez Moreno, Claes B. Wollheim, Kai Hui Hu He, Deborah Aeberhard, Fabrizio Thorel, Marion Cornu, Benoit R. Gauthier, Petra I. Lorenzo, Jorge Vallejo Ortega, Pedro Luis Herrera, Thierry Brun, Bernard Thorens, Paolo Meda
Publikováno v:
Diabetes
Diabetes, Vol. 60, No 6 (2011) pp. 1705-15
Diabetes; Vol 60
Diabetes, vol. 60, no. 6, pp. 1705-1715
Digital.CSIC. Repositorio Institucional del CSIC
instname
Diabetes, Vol. 60, No 6 (2011) pp. 1705-15
Diabetes; Vol 60
Diabetes, vol. 60, no. 6, pp. 1705-1715
Digital.CSIC. Repositorio Institucional del CSIC
instname
et al.
[Objective]: To establish the role of the transcription factor Pax4 in pancreatic islet expansion and survival in response to physiological stress and its impact on glucose metabolism, we generated transgenic mice conditionally and select
[Objective]: To establish the role of the transcription factor Pax4 in pancreatic islet expansion and survival in response to physiological stress and its impact on glucose metabolism, we generated transgenic mice conditionally and select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43996fb6545ff2cf025baf9d4ab3104
https://doi.org/10.2337/db10-1102
https://doi.org/10.2337/db10-1102
Autor:
Francesca Frigerio, Søren Fisker Schmidt, Lars la Cour Poulsen, Pierre Maechler, Michael Boergesen, Susanne Mandrup
Publikováno v:
The Journal of biological chemistry
Boergesen, M, Poulsen, L L C, Schmidt, S F, Frigerio, F, Maechler, P & Mandrup, S 2011, ' ChREBP Mediates Glucose Repression of Peroxisome Proliferator-activated Receptor {alpha} Expression in Pancreatic {beta}-Cells ', Journal of Biological Chemistry, vol. 286, no. 15, pp. 13214-13225 . https://doi.org/10.1074/jbc.M110.215467
Journal of Biological Chemistry, Vol. 286, No 15 (2011) pp. 13214-25
Boergesen, M, Poulsen, L L C, Schmidt, S F, Frigerio, F, Maechler, P & Mandrup, S 2011, ' ChREBP Mediates Glucose Repression of Peroxisome Proliferator-activated Receptor {alpha} Expression in Pancreatic {beta}-Cells ', Journal of Biological Chemistry, vol. 286, no. 15, pp. 13214-13225 . https://doi.org/10.1074/jbc.M110.215467
Journal of Biological Chemistry, Vol. 286, No 15 (2011) pp. 13214-25
Chronic exposure to elevated levels of glucose and fatty acids leads to dysfunction of pancreatic β-cells by mechanisms that are only partly understood. The transcription factor peroxisome proliferator-activated receptor α (PPARα) is an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae9b8a2ff1fd58876384a3edb2c9166
Publikováno v:
Biochemical Society Transactions, Vol. 36, No Pt 5 (2008) pp. 930-4
Pancreatic β-cells are essential for the maintenance of glucose homoeostasis, and dysfunction of these insulin-secreting cells results in the development of diabetes. In the course of events leading from obesity to Type 2 diabetes, several mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e4b73fc1f8d3b4240a6410669dcb86
https://doi.org/10.1042/bst0360930
https://doi.org/10.1042/bst0360930
Autor:
Helene Perreten, Nathalie Produit-Zengaffinen, Alexandre Sarre, Patrick Muzzin, Françoise Assimacopoulos-Jeannet, Sandrine Galetti
Publikováno v:
Pflügers Archiv, Vol. 457, No 4 (2009) pp. 931-40
UCP2 is expressed in pancreatic beta cells where its postulated uncoupling activity will modulate glucose-induced changes in ATP/ADP ratio and insulin secretion. The consequences of UCP2 over/underexpression on beta-cell function has mainly been stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57133fbfcded2e30d1074fc0d790c06b
https://doi.org/10.1007/s00424-008-0548-8
https://doi.org/10.1007/s00424-008-0548-8
Autor:
Peter White, Richard H. Goodman, Claes B. Wollheim, Haiyan Wang, Athanasios Arsenlis, Klaus H. Kaestner, Shannon K. McWeeney, Christopher V.E. Wright, Jacques Drouin, David M. Keller
Publikováno v:
Journal of Biological Chemistry, Vol. 282, No 44 (2007) pp. 32084-92
The homeobox transcription factor Pdx-1 is necessary for pancreas organogenesis and beta cell function, however, most Pdx-1-regulated genes are unknown. To further the understanding of Pdx-1 in beta cell biology, we have characterized its genomic tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad3df36a7eeba99720ea277df4828b9
https://doi.org/10.1074/jbc.m700899200
https://doi.org/10.1074/jbc.m700899200