Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Insulin-Secreting Cells/cytology"'
Autor:
Mathie Tenenbaum, Amar Abderrahmani, Amélie Bonnefond, Stéphane Dalle, Julien Bourry, Valery Gmyr, Philippe Froguel, Valérie Pawlowski, Nicole Beeler, Valérie Plaisance, Raphael Boutry, Hélène Ezanno, Clara Sanchez-Parra, Cécile Jacovetti, Romano Regazzi, Gianni Pasquetti, François Pattou, Syu-Ichi Hirai, Julie Kerr-Conte
Publikováno v:
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 2021, 78 (1), pp.287-298. ⟨10.1007/s00018-020-03499-7⟩
Cellular and molecular life sciences, vol. 78, no. 1, pp. 287-298
Cellular and Molecular Life Sciences, Springer Verlag, 2021, 78 (1), pp.287-298. ⟨10.1007/s00018-020-03499-7⟩
Cellular and Molecular Life Sciences, 2021, 78 (1), pp.287-298. ⟨10.1007/s00018-020-03499-7⟩
Cellular and molecular life sciences, vol. 78, no. 1, pp. 287-298
Cellular and Molecular Life Sciences, Springer Verlag, 2021, 78 (1), pp.287-298. ⟨10.1007/s00018-020-03499-7⟩
International audience; Unveiling the key pathways underlying postnatal beta-cell proliferation can be instrumental to decipher the mechanisms of beta-cell mass plasticity to increased physiological demand of insulin during weight gain and pregnancy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfdfb9a0f864edaf26216a8dbe28497
https://hal.science/hal-03142227/document
https://hal.science/hal-03142227/document
Autor:
Perez-Frances, Marta, van Gurp, Léon, Abate, Maria Valentina, Cigliola, Valentina, Furuyama, Kenichiro, Bru-Tari, Eva, Oropeza, Daniel, Carreaux, Taïna, Fujitani, Yoshio, Thorel, Fabrizio, Herrera, Pedro L.
Publikováno v:
Nature Communications, Vol. 12, No 1 (2021) P. 4458
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The cellular identity of pancreatic polypeptide (Ppy)-expressing γ-cells, one of the rarest pancreatic islet cell-type, remains elusive. Within islets, glucagon and somatostatin, released respectively from α- and δ-cells, modulate the secretion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0e274366e2ce886b3c58fa685badcbbd
https://archive-ouverte.unige.ch/unige:153672
https://archive-ouverte.unige.ch/unige:153672
Autor:
Esther Lizárraga-Mollinedo, Jean Valéry Turatsinze, Maria Inês Alvelos, Olatz Villate, Jonàs Juan-Mateu, Piero Marchetti, Marco Bugliani, Fabio Arturo Grieco, Laura Marroquí, Decio L. Eizirik
Publikováno v:
Diabetes
Diabetes (New York, N.Y.)
Diabetes (New York, N.Y.)
Progressive failure of insulin-producing beta cells is the central event leading to diabetes, but the signalling networks controlling beta cell fate remain poorly understood. Here we show that SRp55, a splicing factor regulated by the diabetes suscep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cb56e6f8858e92b787f798306a9c39
https://doi.org/10.2337/db17-0736
https://doi.org/10.2337/db17-0736
Autor:
Simranjeet Kaur, Thomas Mandrup-Poulsen, Peter de Hemmer Horskjær, Christine Bruun, Joachim Størling, Flemming Pociot, Tina Fløyel, Anna L. Vestergaard, Romano Regazzi, Claus Heiner Bang-Berthelsen, Lukas Adrian Berchtold, Jonathan Lucien Stahl, Lisa Christen, Farzaneh Taheri Sotudeh, Klaus Stensgaard Frederiksen, Frida Greek Kofod
Publikováno v:
Vestergaard, A L, Bang-Berthelsen, C H, Floyel, T, Stahl, J L, Christen, L, Sotudeh, F T, Horskjaer, P D H, Frederiksen, K S, Kofod, F G, Bruun, C, Berchtold, L A, Storling, J, Regazzi, R, Kaur, S, Pociot, F & Mandrup-Poulsen, T 2018, ' MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage ', PLOS ONE, vol. 13, no. 9, e0203713, pp. 1-22 . https://doi.org/10.1371/journal.pone.0203713
PloS one, vol. 13, no. 9, pp. e0203713
PLoS ONE
PLoS ONE, Vol 13, Iss 9, p e0203713 (2018)
PloS one, vol. 13, no. 9, pp. e0203713
PLoS ONE
PLoS ONE, Vol 13, Iss 9, p e0203713 (2018)
Inflammatory β-cell failure contributes to type 1 and type 2 diabetes pathogenesis. Pro-inflammatory cytokines cause β-cell dysfunction and apoptosis, and lysine deacetylase inhibitors (KDACi) prevent β-cell failure in vitro and in vivo, in part b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb30b397012919ce28ea03bcc811726
https://curis.ku.dk/ws/files/210015667/journal.pone.0203713.pdf
https://curis.ku.dk/ws/files/210015667/journal.pone.0203713.pdf
Autor:
Harry Heimberg, Gunter Leuckx, Eelco J.P. de Koning, Yves Heremans, Yannick Verdonck, Carlo Heirman, Nico De Leu, Willem Staels, Kris Thielemans, Sofie De Groef, Luc Baeyens, Conny Gysemans
Publikováno v:
Diabetologia
Diabetologia, 61(8), 1804-1810. Springer Verlag GmbH
Diabetologia, 61(8), 1804-1810
Diabetologia, 61(8), 1804-1810. Springer Verlag GmbH
Diabetologia, 61(8), 1804-1810
AIMS/HYPOTHESIS: The initial avascular period following islet transplantation seriously compromises graft function and survival. Enhancing graft revascularisation to improve engraftment has been attempted through virus-based delivery of angiogenic tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b100c72cd3e3cada71a31757b7068e7
https://doi.org/10.1007/s00125-018-4646-7
https://doi.org/10.1007/s00125-018-4646-7
Autor:
Mark C. Poznansky, Thierry Berney, Luhan Yang, Jon S. Odorico, Melanie L. Graham, Julia L. Greenstein, Lorenzo Piemonti, Bart O. Roep, Melissa K. Carpenter, Kevin A. D'Amour, Chad A. Cowan, Jose Oberholzer, C Ricordi, Alice A. Tomei, James F. Markmann, Ludovic Vallier, Albert Hwa, Dieter Egli, Giuseppe Orlando, Ali Naji, Michael R. Rickels, Giovanni Migliaccio, Shane T. Grey, Bernhard J. Hering, Thomas W.H. Kay, Dale L. Greiner, Ann Jensen Adams, Cristina Nostro, Barbara Ludwig, Qizhi Tang, Alireza Rezania, Daniel Pipeleers, Danwei Huangfu, Uri Ben-David, Douglas A. Melton, Daniel G. Anderson
Publikováno v:
Transplantation
Transplantation (2018)
Transplantation, 102(8), 1223-1229
Transplantation, vol 102, iss 8
Transplantation (2018)
Transplantation, 102(8), 1223-1229
Transplantation, vol 102, iss 8
Beta cell replacement has the potential to restore euglycemia in patients with insulin dependent diabetes. While great progress has been made in establishing allogeneic islet transplantation from deceased donors as the standard of care for those with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f5df07c7122eecb6ecd7e2a579770e
https://hdl.handle.net/1887/87310
https://hdl.handle.net/1887/87310
Autor:
Gunter Leuckx, Charlotte L. Mattsson, Olov Andersson, Palle Serup, Yannick Verdonck, Daisuke Sakano, Philip A. Seymour, Shoen Kume, Harry Heimberg, Ka-Cheuk Liu, Linn Rautio, Willem Staels
Inhibition of notch signaling is known to induce differentiation of endocrine cells in zebrafish and mouse. After performing an unbiased in vivo screen of ∼2,200 small molecules in zebrafish, we identified an inhibitor of Cdk5 (roscovitine), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad66abacc528e8ffc36c37c6428c4f22
https://hdl.handle.net/20.500.14017/5b5273b5-2425-471d-9bde-51524e0f5e0a
https://hdl.handle.net/20.500.14017/5b5273b5-2425-471d-9bde-51524e0f5e0a
Autor:
Sophie Rome, Karim Bouzakri, Francesca Mancarella, Francesco Dotta, Bryan J. González, Christian Boitard, Romano Regazzi, Niels L. Mulder, Véronique Menoud, Alena Donda, Janine K. Kruit, Camilla Jandus, Angelika Jurdzinski, Pedro Romero, Guido Sebastiani, Claudiane Guay, Michel Pinget
Publikováno v:
Cell Metab
Cell Metab, 2018
Cell Metabolism
Cell Metabolism, Elsevier, 2019, 29 (2), pp.348-361. ⟨10.1016/j.cmet.2018.09.011⟩
Cell Metabolism, 2019, 29 (2), pp.348-361. ⟨10.1016/j.cmet.2018.09.011⟩
Cell Mol Immunol
Cell metabolism, 29(2), 348-+. CELL PRESS
Cell metabolism, vol. 29, no. 2, pp. 348-361.e6
Cell Metabolism, Vol. 29, No 2 (2019) pp. 348-361.e6
Cell Metab, 2018
Cell Metabolism
Cell Metabolism, Elsevier, 2019, 29 (2), pp.348-361. ⟨10.1016/j.cmet.2018.09.011⟩
Cell Metabolism, 2019, 29 (2), pp.348-361. ⟨10.1016/j.cmet.2018.09.011⟩
Cell Mol Immunol
Cell metabolism, 29(2), 348-+. CELL PRESS
Cell metabolism, vol. 29, no. 2, pp. 348-361.e6
Cell Metabolism, Vol. 29, No 2 (2019) pp. 348-361.e6
International audience; Type 1 diabetes is an autoimmune disease initiated by the invasion of pancreatic islets by immune cells that selectively kill the beta cells. We found that rodent and human T lymphocytes release exosomes containing the microRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f878c654b1d2d4d0be201a71ca77ec53
https://hal.archives-ouvertes.fr/hal-02003439
https://hal.archives-ouvertes.fr/hal-02003439
Autor:
Amar Abderrahmani, Romano Regazzi, Sonia Gattesco, Paolo Meda, Aurore Britan, E. Roggli, Nathalie Lin-Marq
Publikováno v:
Diabetes
Diabetes, Vol. 59, No 4 (2010) pp. 978-986
Diabetes, vol. 59, no. 4, pp. 978-986
Diabetes, Vol. 59, No 4 (2010) pp. 978-986
Diabetes, vol. 59, no. 4, pp. 978-986
OBJECTIVE Pancreatic β-cells exposed to proinflammatory cytokines display alterations in gene expression resulting in defective insulin secretion and apoptosis. MicroRNAs are small noncoding RNAs emerging as key regulators of gene expression. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9709a9936a1e4a8d39d999bb4e8e06d
Autor:
Guay, C., Regazzi, R.
Publikováno v:
Diabetes, obesity & metabolism, vol. 19 Suppl 1, pp. 137-146
Blood glucose homeostasis requires a constant communication between insulin-secreting and insulin-sensitive cells. A wide variety of circulating factors, including hormones, cytokines and chemokines work together to orchestrate the systemic response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1900::c20028d14e9ebce5443336d9a20cc3b3
https://serval.unil.ch/notice/serval:BIB_67B77266C639
https://serval.unil.ch/notice/serval:BIB_67B77266C639