Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability

Autor: Anne Mette Frøbert, Malene Brohus, Tinna S. Roesen, Jonas Kindberg, Ole Fröbert, Cheryl A. Conover, Michael T. Overgaard

Publikováno v: Frøbert, A M, Brohus, M, Roesen, T S, Kindberg, J, Fröbert, O, Conover, C A & Overgaard, M T 2022, ' Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability ', American Journal of Physiology-Endocrinology and Metabolism, vol. 323, no. 3, pp. E307-E318 . https://doi.org/10.1152/ajpendo.00429.2021
Frøbert, A M, Brohus, M, Roesen, T S, Kindberg, J, Fröbert, O, Conover, C A & Overgaard, M T 2022, ' Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability ', American Journal of Physiology: Endocrinology and Metabolism, vol. 323, no. 3, pp. E307-E318 . https://doi.org/10.1152/ajpendo.00429.2021

Brown bears conserve muscle and bone mass during 6 mo of inactive hibernation. The molecular mechanisms underlying hibernation physiology may have translational relevance for human therapeutics. We hypothesize that protective mechanisms involve incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b57d1594d1d384c49a2a5c357e2840f
https://pure.au.dk/portal/da/publications/circulating-insulinlike-growth-factor-system-adaptations-in-hibernating-brown-bears-indicate-increased-tissue-igf-availability(7ab93ef1-880c-49f0-aba1-c2d20bf72ce7).html

Increases in Bioactive IGF do not Parallel Increases in Total IGF-I During Growth Hormone Treatment of Children Born SGA

Autor: Mathilde Gersel Wegmann, Guftar Shaikh, Olle Söder, Sten A. Ivarsson, Edna Roche, Jeremy Kirk, Anders Juul, David B. Dunger, Hilary Hoey, Rikke Beck Jensen, Ajay Thankamony, Jan Frystyk

Publikováno v: Wegmann, M G, Jensen, R B, Thankamony, A, Frystyk, J, Roche, E, Hoey, H, Kirk, J, Shaikh, G, Ivarsson, S-A, Söder, O, Dunger, D B & Juul, A 2020, ' Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA ', The Journal of clinical endocrinology and metabolism, vol. 105, no. 4, dgz118, pp. E1291-E1298 . https://doi.org/10.1210/clinem/dgz118
Wegmann, M G, Jensen, R B, Thankamony, A, Frystyk, J, Roche, E, Hoey, H, Kirk, J, Shaikh, G, Ivarsson, S-A, Söder, O, Dunger, D B & Juul, A 2020, ' Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA ', The Journal of clinical endocrinology and metabolism, vol. 105, no. 4, dgz118 . https://doi.org/10.1210/clinem/dgz118
Wegmann, M G, Jensen, R B, Thankamony, A, Frystyk, J, Roche, E, Hoey, H, Kirk, J, Shaikh, G, Ivarsson, S-A, Söder, O, Dunger, D B & Juul, A 2020, ' Increases in Bioactive IGF do not Parallel Increases in Total IGF-I During Growth Hormone Treatment of Children Born SGA ', Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 4, pp. e1291–e1298 . https://doi.org/10.1210/clinem/dgz118

Background Some children born small for gestational age (SGA) experience supra-physiological insulin-like growth factor-I (IGF-I) concentrations during GH treatment. However, measurements of total IGF-I concentrations may not reflect the bioactive fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01049f1a4b1770de08a4410d843ee448
https://pubmed.ncbi.nlm.nih.gov/31665326

Reversible Albumin-Binding GH Possesses a Potential Once-Weekly Treatment Profile in Adult Growth Hormone Deficiency

Autor: Michael Højby Rasmussen, Djordje Marina, Ulla Feldt-Rasmussen, Mette Tanvig, Marianne Klose, Marianne Andersen, Lene From Nielsen, Jurgita Janukonyte, Jens Sandahl Christiansen, Charlotte Höybye

Publikováno v: Rasmussen, M H, Janukonyte, J, Klose, M, Marina, D, Tanvig, M H, Nielsen, L F, Höybye, C, Andersen, M, Feldt-Rasmussen, U & Christiansen, J S 2016, ' Reversible Albumin-Binding GH Possesses a Potential Once-Weekly Treatment Profile in Adult Growth Hormone Deficiency ', Journal of Clinical Endocrinology and Metabolism, vol. 101, no. 3, pp. 988–998 . https://doi.org/10.1210/jc.2015-1991
Rasmussen, M H, Janukonyté, J, Klose, M, Marina, D, Tanvig, M, Nielsen, L F, Höybye, C, Andersen, M, Feldt-Rasmussen, U & Christiansen, J S 2016, ' Reversible albumin-binding GH possesses a potential once-weekly treatment profile in adult growth hormone deficiency ', Journal of Clinical Endocrinology and Metabolism, vol. 101, no. 3, pp. 988-998 . https://doi.org/10.1210/jc.2015-1991

Context: NNC0195-0092 is a reversible, albumin-binding GH derivative, developed for once-weekly administration. Objectives: The objective of the study was to evaluate safety, local tolerability, pharmacodynamics, and pharmacokinetics of multiple, onc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f428bdeabae341b8e4d25dbebab962a
https://portal.findresearcher.sdu.dk/da/publications/1cb82f1d-6dd2-4572-a250-1d7b69fbb3eb

Evolution of IGF-1 in children born small for gestational age and with growth retardation, treated by growth hormone adapted to IGF-1 levels after 1 year

Autor: L Perin, Michel Colle, Régis Coutant, Sylvie Cabrol, Paul Czernichow, Monique Jesuran-Perelroizen, Y. Le Bouc

Publikováno v: Hormone Research in Paediatrics
Hormone Research in Paediatrics, 2011, 76 (6), pp.419-27. ⟨10.1159/000334651⟩

Aim: This study was designed to estimate the percentage of growth hormone (GH)-treated children born small for gestational age (SGA), with serum IGF-1 >2 SDS before and after GH dose adaptation. Methods: SGA boys aged 4–9 and girls aged 4–7 with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e9851133392ba726a53028c3934aeb
https://hal.univ-angers.fr/hal-03408475

Postnatal Decrease in Circulating Insulin-Like Growth Factor-I and Low Brain Volumes in Very Preterm Infants

Autor: Ann Hellström, Ingrid Hansen-Pupp, Vineta Fellman, Elna-Marie Larsson, Petra Susan Hüppi, Chatarina Löfqvist, Lena Hellström-Westas, François Lazeyras, Holger Hövel, David Ley

Publikováno v: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No 4 (2011) pp. 1129-35
The Journal of clinical endocrinology and metabolism; 96(4), pp 1129-1135 (2011)

Context: IGF-I and IGF binding protein-3 (IGFBP-3) are essential for growth and maturation of the developing brain. Objective: The aim of this study was to evaluate the association between postnatal serum concentrations of IGF-I and IGFBP-3 and brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b27aa9d635882d76fbf1ab1990de737
http://lup.lub.lu.se/record/1832326